Placenta‐on‐a‐Chip: Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier (Adv. Healthcare Mater. 2/2018)

Blundell, Cassidy; Yi, Yoon-Suk; Ma, Lin; Tess, Emily R.; Farrell, Megan J.; Georgescu, Andrei; Aleksunes, Lauren M.

doi:10.1002/adhm.201870008

Cited by 3 publications

(1 citation statement)

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“…Taken together, our results strongly suggest that appropriate design of adhesive culture patterns and the mechanical microenvironment surrounding microtissues can serve as critically important design parameters to enhance fusion in vitro. Exploring this design space will be of critical importance when developing next-generation drug screening technologies such as “organ-on-a-chip” platforms, including recently developed placenta-on-a-chip model systems, , which will ultimately enhance our understanding of these complex biological systems and provide a versatile set of tools to improve disease modeling and therapeutic development strategies.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic Micropatterned Adhesive Surfaces To Mechanobiologically Regulate Placental Trophoblast Fusion

Sagrillo-Fagundes

Tran

et al. 2019

ACS Appl. Mater. Interfaces

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The placental syncytiotrophoblast is a giant multinucleated cell that forms a tree-like structure and regulates transport between mother and baby during development. It is maintained throughout pregnancy by continuous fusion of trophoblast cells, and disruptions in fusion are associated with considerable adverse health effects including diseases such as preeclampsia. Developing predictive control over cell fusion in culture models is hence of critical importance in placental drug discovery and transport studies, but this can currently be only partially achieved with biochemical factors. Here, we investigate whether biophysical signals associated with budding morphogenesis during development of the placental villous tree can synergistically direct and enhance trophoblast fusion. We use micropatterning techniques to manipulate physical stresses in engineered microtissues and demonstrate that biomimetic geometries simulating budding robustly enhance fusion and alter spatial patterns of synthesis of pregnancy-related hormones. These findings indicate that biophysical signals play a previously unrecognized and significant role in regulating placental fusion and function, in synergy with established soluble signals. More broadly, our studies demonstrate that biomimetic strategies focusing on tissue mechanics can be important approaches to design, build, and test placental tissue cultures for future studies of pregnancy-related drug safety, efficacy, and discovery.

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Section: Discussionmentioning

confidence: 99%

Biomimetic Micropatterned Adhesive Surfaces To Mechanobiologically Regulate Placental Trophoblast Fusion

Sagrillo-Fagundes

Tran

et al. 2019

ACS Appl. Mater. Interfaces

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Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges

et al. 2021

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New emerging technologies, remarkably miniaturized 3D organ models and microfluidics, enable simulation of the real in vitro microenvironment ex vivo more closely. There are many fascinating features of innovative organ‐on‐a‐chip (OOC) technology, including the possibility of integrating semipermeable and/or stretchable membranes, creating continuous perfusion of fluids into microchannels and chambers (while maintaining laminar flow regime), embedding microdevices like microsensors, microstimulators, micro heaters, or different cell lines, along with other 3D cell culture technologies. OOC systems are designed to imitate the structure and function of human organs, ranging from breathing lungs to beating hearts. This technology is expected to be able to revolutionize cell biology studies, personalized precision medicine, drug development process, and cancer diagnosis/treatment. OOC systems can significantly reduce the cost associated with tedious drug development processes and the risk of adverse drug reactions in the body, which makes drug screening more effective. The review mainly focus on presenting an overview of the several previously developed OOC systems accompanied by subjects relevant to pharmacy‐, cancer‐, and placenta‐on‐a‐chip. The challenging issues and opportunities related to these systems are discussed, along with a future perspective for this technology.

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State of the Art in Integrated Biosensors for Organ-on-a-Chip Applications

Dey,

Mitra,

Chakraborty

et al. 2024

Smart Nanomaterials Technology

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Placenta‐on‐a‐Chip: Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier (Adv. Healthcare Mater. 2/2018)

Cited by 3 publications

References 0 publications

Biomimetic Micropatterned Adhesive Surfaces To Mechanobiologically Regulate Placental Trophoblast Fusion

Biomimetic Micropatterned Adhesive Surfaces To Mechanobiologically Regulate Placental Trophoblast Fusion

Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges

State of the Art in Integrated Biosensors for Organ-on-a-Chip Applications

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