Placental ABCA1 and ABCG1 expression in gestational disease: Pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts

Baumann, Marc; Körner, Meike; Huang, Xiao; Wenger, F.; Surbek, Daniel; Albrecht, Christiane

doi:10.1016/j.placenta.2013.06.309

Cited by 52 publications

(51 citation statements)

References 31 publications

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“…Secondly, previous studies from us, and others, have reported that, despite of the localization of both ABCA1 and ABCG1 in placental tissues and cells [11,12,13], only placental ABCA1 expression (but not ABCG1) exhibits a gestational-age-dependent expression pattern [14], suggesting a key role of this protein in transplacental cholesterol transport during gestation.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have identified ABCA1 and ABCG1 in placental tissues and cells at various cellular localizations [11,12,13,14]. Further investigations revealed that only the abundance of placental ABCA1 (but not ABCG1) exhibited dependence on the gestational age [14], supporting the involvement of ABCA1 with adequate in utero development of the fetus.…”

Section: Introductionmentioning

confidence: 99%

“…Further investigations revealed that only the abundance of placental ABCA1 (but not ABCG1) exhibited dependence on the gestational age [14], supporting the involvement of ABCA1 with adequate in utero development of the fetus. In support of this assumption, a decrease of placental ABCA1 expression and cholesterol transport activity was observed in the gestational disease pre-eclampsia [14,15]. Moreover, deletion of ABCA1 in mice led to an approximately 30% decrease in transfer of maternal cholesterol to the fetus, while suppression of ABCG1 did not affect the transfer process [16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel Insights into Concepts and Directionality of Maternal–Fetal Cholesterol Transfer across the Human Placenta

Kallol

Huang

Müller

et al. 2018

IJMS

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Cholesterol is indispensable for cellular membrane composition and function. It is also a precursor for the synthesis of steroid hormones, which promote, among others, the maturation of fetal organs. A role of the ATP-binding-cassette-transporter-A1 (ABCA1) in the transport of maternal cholesterol to the fetus was suggested by transferring cholesterol to apolipoprotein-A-1 (apo-A1), but the directionality of the apoA-1/ABCA1-dependent cholesterol transport remains unclear. We isolated primary trophoblasts from term placentae to test the hypotheses that (1) apoA-1/ABCA1 dispatches cholesterol mainly towards the fetus to support fetal developmental maturation at term, and (2) differentiated syncytiotrophoblasts (STB) exert higher cholesterol transport activity than undifferentiated cytotrophoblasts (CTB). As experimental models, we used (1) trophoblast monolayers grown on Transwell® system consisting of apical (maternal-like) and basal (fetal-like) compartments, and (2) trophoblasts grown on conventional culture plates at CTB and STB stages. Surprisingly, apoA-1-mediated cholesterol efflux operated almost exclusively at the apical-maternal side, where ABCA1 was also localized by immunofluorescence. We found greater cholesterol efflux capacity in STB, which was increased by liver-X-receptor agonist treatment and decreased by ABCA1 inhibition. We conclude that at term the apoA-1/ABCA1 pathway is rather involved in cholesterol transport to the mother than in transfer to the fully developed fetus.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Insights into Concepts and Directionality of Maternal–Fetal Cholesterol Transfer across the Human Placenta

Kallol

Huang

Müller

et al. 2018

IJMS

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“…In addition, application of different cell culture systems, beyond the rather artificial model, given by the choriocarcinoma BeWo cell lines, by use of carefully isolated and thoroughly characterized primary term human trophoblasts adds further merit (28). A few limitations exist; first, although placental growth is significant in the second trimester, isolated human primary trophoblasts were not available within this time frame without further comorbid conditions precluding their use.…”

Section: Discussionmentioning

confidence: 99%

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation

et al. 2016

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“…Although the exact mechanisms of action and directionalities of transplacental lipid exchange through these two transporters are not fully understood, a role for ABCA1 and ABCG1 in mediating efflux of cholesterol from human fetal endothelial cells to the fetal circulation has been suggested previously 28,29 .…”

Section: Accepted Articlementioning

confidence: 99%

Maternal–fetal cholesterol transport in the second half of mouse pregnancy does not involve LDL receptor‐related protein 2

et al. 2017

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Maternal-fetal cholesterol transport and endogenous fetal cholesterol synthesis depend on maternal cholesterol concentrations but do not involve LRP2 in the second half of murine pregnancy. Our results suggest that the mouse fetus can compensate for decreased maternal cholesterol levels. It remains a relevant question how the delicate system of cholesterol transport and synthesis is regulated in the human fetus and placenta.

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Placental ABCA1 and ABCG1 expression in gestational disease: Pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts

Cited by 52 publications

References 31 publications

Novel Insights into Concepts and Directionality of Maternal–Fetal Cholesterol Transfer across the Human Placenta

Novel Insights into Concepts and Directionality of Maternal–Fetal Cholesterol Transfer across the Human Placenta

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation

Maternal–fetal cholesterol transport in the second half of mouse pregnancy does not involve LDL receptor‐related protein 2

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