Placental glutathione S-transferase isoenzyme expression in polycyclic aromatic hydrocarbon-induced hamster buccal pouch mucosa

Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-β-cyclodextrin

“…RV antineoplastic mechanisms are extensively reviewed. 7,30 Although many of these pathways are altered during DMBA cancerogenesis, [31][32][33][34] and RV may act through several mechanisms, its ability to interfere with the formation of chemically-induced DNA adducts seems of major importance in OSCC prevention. OSCCs have been aetiologically and epidemiologically linked with chemical carcinogens, such as the polycyclic aromatic hydrocarbons (PAHs, e.g.…”

Clinical significance of P-glycoprotein and glutathione S-transferase π expression in gallbladder carcinoma

“…It has been previously suggested that aromatic compounds can induce GST-π expression (21,22). In addition, it is well known that GBC is closely associated with gallstone and chronic cholecystitis, which may generate aromatic compounds due to the long-term stasis of bile and bacterial infection (23).…”

Role of Glutathione S-Transferases in Lens under Oxidative Stress

“…[39][40][41] This induction of GSTP can lead to cancer or tumor cell multidrug resistance, but certain reductants, such as curcumin, are able to inhibit this induction of this GSTP gene such that the cancer cells are induced to enter appoptosis. Furthermore, GSTP directly inhibited c-Jun N-terminal kinase (JNK) so as to prevent cells from oxidative-damage triggered apoptosis in liver, embryo fibroblasts and PC12 cells.…”