Placental growth factor mediates aldosterone-dependent vascular injury in mice

Jaffe, Iris Z.; Newfell, Brenna G.; Aronovitz, Mark; Mohammad, Najwa N.; McGraw, Adam P.; Perreault, Roger E.; Carmeliet, Peter; Ehsan, Afshin; Mendelsohn, Michael E.

doi:10.1172/jci40205

Cited by 69 publications

(92 citation statements)

References 59 publications

(78 reference statements)

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“…32,33) In mouse vessels with endothelial damage and human vessels from patients with atherosclerosis, aldosterone enhanced expression of PlGF and its receptor, Flt-1. 34) In atherosclerotic human vessels, MR antagonists were reported to inhibit PlGF expression. 34) In a mouse carotid wire injury model, aldosterone infusion accelerated vascular remodeling, and the effect was lost in PlGF knockout mice.…”

Section: Discussionmentioning

confidence: 99%

“…34) In atherosclerotic human vessels, MR antagonists were reported to inhibit PlGF expression. 34) In a mouse carotid wire injury model, aldosterone infusion accelerated vascular remodeling, and the effect was lost in PlGF knockout mice. 34) PlGF may be a novel downstream target of vascular MR that mediates aldosterone-related angiogenesis in failing hearts, as well as in vascular remodeling.…”

Section: Discussionmentioning

confidence: 99%

“…34) In a mouse carotid wire injury model, aldosterone infusion accelerated vascular remodeling, and the effect was lost in PlGF knockout mice. 34) PlGF may be a novel downstream target of vascular MR that mediates aldosterone-related angiogenesis in failing hearts, as well as in vascular remodeling. These findings suggest a nonrenal mechanism for the vascular protective effects of aldosterone antagonists in humans and supports targeting the vascular aldosterone/MR/PlGF/Flt-1 pathway as a therapeutic strategy for ischemic heart failure and cardiac remodeling.…”

Section: Discussionmentioning

confidence: 99%

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Soluble Fms-like Tyrosine Kinase 1 Is a Novel Predictor of Brain Natriuretic Peptide Elevation

et al. 2013

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SummarySoluble fms-like tyrosine kinase 1 (sFlt-1) is an endogenous inhibitor of vascular endothelial growth factor, which is involved in cardiovascular remodeling and atherosclerosis development. To examine the predictive role of sFlt-1 levels in patients with asymptomatic heart failure, we measured circulating sFlt-1 in patients with or without coronary artery disease (CAD). We analyzed 88 Japanese patients with CAD or patients at high risk for atherosclerosis and who were undergoing total risk management for cardiovascular disease prevention. Circulating sFlt-1 levels correlated with the increase in plasma brain natriuretic peptide levels (ΔBNP) from baseline to the observed levels 5 years later in CAD patients, patients with previous myocardial infarction, and men. ΔBNP levels correlated with sFlt-1 levels in the high-sFlt-1 patients with CAD (r = 0.511, P < 0.01). In all patients, end-systolic volume index (ΔESVI) increased in correlation with a decrease in left ventricular ejection fraction (ΔEF) in the long-term observation, independent of their history of myocardial infarction (ΔESVI = 2.5 mL/m 2 increase/year). Baseline level of sFlt-1 was independent of ΔESVI or ΔEF. The present 5-year observational study demonstrated that high sFlt-1 levels predicted moderate increases in BNP levels in CAD patients. Moreover, ΔBNP was correlated with ΔESVI/year in CAD patients with high-sFlt-1 levels. These data suggest that high sFlt-1 levels may be an effective biomarker to predict the progression of heart failure in patients with CAD. (Int Heart J 2013; 54: 133-139)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Soluble Fms-like Tyrosine Kinase 1 Is a Novel Predictor of Brain Natriuretic Peptide Elevation

et al. 2013

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“…Organ fibrosis and atherosclerosis are promoted by excess aldosterone (10). Upon exposure of vessels to aldosterone in models of atherosclerosis, enhanced placental growth factor (PlGF) expression has been observed, mediated by a mineralocorticoid responsive element in the promoter region of plgf (10,11). In non-pregnant systemic vasculature, aldosterone-dependent PlGF expression leads to vascular injury, atherosclerosis, plaque formation and its inflammatory response (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Upon exposure of vessels to aldosterone in models of atherosclerosis, enhanced placental growth factor (PlGF) expression has been observed, mediated by a mineralocorticoid responsive element in the promoter region of plgf (10,11). In non-pregnant systemic vasculature, aldosterone-dependent PlGF expression leads to vascular injury, atherosclerosis, plaque formation and its inflammatory response (10,11). PlGF is considered to be crucial in pregnancy to initiate and perpetuate placental angiogenesis (reviewed in Zygmunt et al Eur J Obstet Gynecol Reprod Biol 2003).…”

Section: Introductionmentioning

confidence: 99%

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation

et al. 2016

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Novel Pathophysiological Mechanisms in Hypertension

Samson

Lee

Lawless

et al. 2016

Advances in Experimental Medicine and Biology

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Hypertension is the most common disease affecting humans and imparts a significant cardiovascular and renal risk to patients. Extensive research over the past few decades has enhanced our understanding of the underlying mechanisms in hypertension. However, in most instances, the cause of hypertension in a given patient continues to remain elusive. Nevertheless, achieving aggressive blood pressure goals significantly reduces cardiovascular morbidity and mortality, as demonstrated in the recently concluded SPRINT trial. Since a large proportion of patients still fail to achieve blood pressure goals, knowledge of novel pathophysiologic mechanisms and mechanism based treatment strategies is crucial. The following chapter will review the novel pathophysiological mechanisms in hypertension, with a focus on role of immunity, inflammation and vascular endothelial homeostasis. The therapeutic implications of these mechanisms will be discussed where applicable.

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Placental growth factor mediates aldosterone-dependent vascular injury in mice

Cited by 69 publications

References 59 publications

Soluble Fms-like Tyrosine Kinase 1 Is a Novel Predictor of Brain Natriuretic Peptide Elevation

Soluble Fms-like Tyrosine Kinase 1 Is a Novel Predictor of Brain Natriuretic Peptide Elevation

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation

Novel Pathophysiological Mechanisms in Hypertension

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