Placental hstology and fetal blood flow in intrauterine growth retardation

Abstract

Placental infarction would seem to be a valuable morphological marker of uteroplacental vascular disease related to IUGR and impaired fetal and umbilical blood flow.

Placental ischemia and changes in umbilical and uteroplacental arterial and venous hemodynamics

“…In agreement with our previous studies [11,13], we have found a strong association between the Doppler findings indicating high resistance to arterial flow on both sides of placenta (BFC I-III and UAS 3-4) and placental ischemic changes expressed as the presence of infarctions and high ischemic score (Table III). The increased inflammatory response that characterises both placental ischemic changes and deciduitis can have contributed to these hemodynamic changes.…”

Histopathological analysis of the placental lesions in pregnancies complicated with IUGR and stillbirths in comparison with noncomplicated pregnancies

“…It is usually of no significance unless it affects more than 10-20% of the placental volume (11). The existence of a relation between fetal hypoxia and placental infarction has been shown (12). In the present study, placental infarction was detected in 58% and 62%, 4% of group I, group II and group III, respectively.…”

Pontosubicular apoptosis (“necrosis”) in human neonates with intrauterine growth retardation and placental infarction

“…The aim of the study was to quantitate the extent of pontosubicular apoptosis in the 17 cases and document any apoptosis in the cerebral cortex as well, using both standard histology and stains specific for apoptosis. Placental infarction is a morphological marker of uteroplacental insufficiency in pregnancies complicated by IUGR [17]. IUGR associated with abnormal blood flow in the umbilical artery is associated with chronic fetal hypoxaemia [23].…”