Placental mesenchymal dysplasia and an estimation of the population incidence

Zeng, Xing; Chen, Moy Fong; Bureau, Yves-André; Brown, Richard N

doi:10.1111/j.1600-0412.2012.01397.x

Cited by 27 publications

(36 citation statements)

References 10 publications

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“…Of the 110 cases reviewed, 16 (14.5%) were associated with BWS [2,3,4,5,6,7,8,9,10], 33 (30.0%) had evidence of fetal growth restriction [4,11,12,13,14,15,16,17,18,19,20,21,22,23,24,41,46,48] as in the current case, and 28 (25.5%) ended in intrauterine fetal death [4,6,7,8,12,13,15,16,17,18,25,26,45,47]. There is a female preponderance in cases of PMD; of the infant data reviewed, there were 78 females and 19 males.…”

Section: Resultsmentioning

confidence: 99%

“…Another characteristic feature of PMD is aneurismal and varicose dilation of fetal chorionic vessels. Of the 110 cases reviewed, 48 cases of PMD presented data of dilation of fetal chorionic vessels [2,3,9,11,12,13,14,15,17,18,20,21,22,23,24,26,34,35,36,40,41,44,45,46,47,48]. Figure 6 represents the gestational age when aneurismal and varicose dilation of chorionic vessels were identified in the 48 cases and the current case.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 110 cases reviewed, 44 cases of PMD showed multicystic placenta in antenatal ultrasound scan [1,2,3,5,7,9,10,11,12,13,16,18,19,20,22,23,26,27,28,29,30,31,32,33,34,41,42,43,44,45,46,47,48]. Figure 5 represents the gestational age at which the multicystic pattern was identified in the 44 cases and the current case.…”

Section: Resultsmentioning

confidence: 99%

“…All articles without an abstract or with unavailable full text were excluded. We identified 49 articles including 110 cases of PMD [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. …”

Section: Literaturementioning

confidence: 99%

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Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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Placental mesenchymal dysplasia (PMD) is characterized by multiple hypoechoic vesicles which are similar to molar changes in the placenta; however, the process of such morphological changes of PMD during pregnancy has not been fully understood. We performed a review of all PMD cases published in English and identified 49 articles including 110 cases. With regard to the gestational age at which the multicystic pattern was seen,approximately 70% of cases were diagnosed at 13-20 weeks of gestation. Another characteristic feature of PMD is varicose dilation of fetal chorionic vessels. As many as 90% of cases were diagnosed as placenta with dilated fetal chorionic vessels in the third trimester. We also report a case of PMD which was found at 10 weeks of gestation according to ultrasonic molar patterns. Serial observations of the placenta using ultrasound and magnetic resonance imaging revealed that multicystic lesions became smaller after 23 weeks. In contrast, dilated placental vessels on the fetal side became apparent at 38 weeks. The present review highlights that placental vesicular lesions of PMD may precede dilation of fetal chorionic vessels during pregnancy. It also indicates the potential of a gradual reduction in size of PMD's placental vesicular lesions by serial study of placental images.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Literaturementioning

confidence: 99%

See 2 more Smart Citations

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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“…True incidence is not known but it has been estimated at 0.02% [4]. However, Zeng et al [5] identified only two cases in 95000 deliveries at their institution. They reported the incidence of 0.02 per 1000, which was lower than that reported before by Arizawa and Nakayama [4].…”

Section: Discussionmentioning

confidence: 99%

A Case of Placental Mesenchymal Dysplasia

Taga

Haraga

Sawada

et al. 2013

Case Reports in Obstetrics and Gynecology

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Placental mesenchymal dysplasia (PMD) rarely complicates with pregnancy. A 30-year-old woman, gravida 3, para 3, presenting with placentomegaly, was referred to our department at 18 weeks of gestation. An ultrasonography revealed a normal fetus with a large multicystic placenta, measuring 125 × 42 × 80 mm. The border between the lesion and normal region was not clear. Color doppler revealed little blood flow in the lesion. Magnetic resonance imaging revealed normal fetus and a large multicystic placenta. Serum human chorionic gonadotropin level was 20124.97 U/L, which was normal at 20 weeks of gestation. Thus, placental mesenchymal dysplasia rather than hydatidiform mole with coexistent fetus was suspected. Then, routine checkup was continued. Because she had the history of Cesarean section, an elective Cesarean section was performed at 37 weeks of gestation, and 2520 g female infant with apgar score 8/9 was delivered. The baby was normal with no evidence of Beckwith-Wiedemann syndrome. Placenta of 20 × 16 × 2 cm, weighing 720 g, was bulky with grape like vesicles involving whole placenta. Microscopic examination revealed dilated villi and vessels with thick wall which was lacking trophoblast proliferation. Large hydropic stem villi with myxomatous struma and cistern formation were seen. PMD was histopathologically confirmed.

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