Placental transfer and distribution of nicotine in the pregnant rhesus monkey

Suzuki, Kotaro; Horiguchi, Terusada; Comas-Urrutia, Arsenio C.; Mueller-Heubach, Eberhard; Morishima, Hisayo O.; Adamsons, Karlis

doi:10.1016/0002-9378(74)90042-8

Cited by 78 publications

(25 citation statements)

References 2 publications

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“…Although the amount of nicotine con tained in the fetus is only a small fraction of the total dose administered to the mo ther [27] it nevertheless appears that the in hibitory effect of maternal nicotine intake during gestation and lactation on fetal and neonatal lung tissue glycogenolysis and glycolysis, is irreversible. The developing fetal lung therefore seems to be very sensi tive to the effects of nicotine.…”

Section: Effect O F Maternal Nicotine Exposure On Glycolysis In Neonamentioning

confidence: 99%

“…It is therefore possible that the placenta, in ad dition to glucose, also exports trioses [33] and amino acids as precursors for fetal lung glycogen. Since nicotine inhibits gly colysis and thus triose formation (table III), and also diminish placental blood flow [35] as well as placental amino acid transfer [34], less substrate will be avail able for glycogenesis in the fetal lung. The lower glycogen content of the nicotine-ex posed fetal lungs at this stage could there fore probably be attributed to suppression of glycogenesis due to a lack of sufficient amounts of precursors.…”

Section: Effect O F Maternal Nicotine Exposure On Glycogenolysis O F mentioning

confidence: 99%

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Maternal Nicotine Exposure and Carbohydrate Metabolism of Fetal and Neonatal Lung Tissue: Response to Nicotine Withdrawal

Maritz¹

1987

Respiration

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The metabolic response of fetal and neonatal lung tissue to maternal nicotine exposure (0.25 and 1.0 mg/kg body weight/day) was investigated. White virgin female rats (Wistar) of 200–250 g were used. The rats were mated overnight and were afterwards randomly assigned to control and experimental groups. The experimental group was subdivided into two groups. One group received nicotine during pregnancy and lactation. The second group received nicotine only during lactation. The suckling rats were killed 24 h after the last dose of nicotine was administered to the mother. The lung tissue was surgically removed and the in vitro utilization of exogenous glucose and endogenous glycogen determined. Lactate production was also determined to assess glycolytic activity. Maternal nicotine administration during pregnancy and lactation stimulated total glucose turnover by 21.6 and 86.4% respectively but suppressed glycogenolysis (32.7%) and glycolysis by 24.6% (p < 0.01). Nicotine administration during lactation only enhanced total glucose turnover by 19.1% (p < 0.01) and glycogenolysis by 30% (p < 0.01) but inhibited glycolysis by 25.8%. After 4 weeks of nicotine withdrawal when the rats were 7 weeks old, glycogenolysis and glycolysis of those animals exposed to nicotine via the placenta and mother’s milk were still inhibited to the same extent as during exposure. Glycogenolysis and the glycolytic flux of lung tissue of rats exposed to nicotine via mother’s milk only returned to normal. Since rat lung tissue has reached maturation at this stage, it is conceivable to assume that exposure to nicotine during pregnancy will have a permanent adverse effect on carbohydrate metabolism in lung tissue and thus on the aspects of lung development and differentiation dependent on these pathways.

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Section: Effect O F Maternal Nicotine Exposure On Glycolysis In Neonamentioning

confidence: 99%

Section: Effect O F Maternal Nicotine Exposure On Glycogenolysis O F mentioning

confidence: 99%

Maternal Nicotine Exposure and Carbohydrate Metabolism of Fetal and Neonatal Lung Tissue: Response to Nicotine Withdrawal

Maritz¹

1987

Respiration

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“…It is therefore likely that the blood concentrations of nicotine reached in the fetus are similar to those in the mother; however, there is no direct evidence supporting the notion. Peak nicotine levels in the pregnant mother's blood occur 15-30 minutes after it is administered [25]. Most of the nicotine that enters the fetus returns to the maternal circulation for elimination, although some enters the amniotic fluid via the fetal urine.…”

Section: Nicotine Uptake and Metabolism During Pregnancymentioning

confidence: 99%

Transgenerational Effects of Maternal Nicotine Exposure During Gestation and Lactation on the Respiratory System

Maritz¹

2012

Point Mutation

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“…Nicotine rapidly crosses the placenta to affect the fetus (20). Fetal hypertension due to blood vessel contraction and bradycardia due to stimulation of the carotid and aortic bodies has been demonstrated in rhesus monkeys (21).…”

Section: Monoxidementioning

confidence: 99%

Smoking among pregnant women - epidemiology and health consequences

Haug¹

2009

Nor J Epidemiol

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Smoking during pregnancy is an important, preventable risk factor for late fetal death and even SIDS. There is a strong dose-response relationship between cigarette smoking and spontaneous abortion, reduction in birth weight, abruptio placentae, placenta previa and bleeding during pregnancy. Ten years ago, the prevalence of smoking among Norwegian pregnant women was between 35 and 40%. During the last 8 years there has been a dramatic change and in 1995 the prevalence seems to be around 20%.

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Placental transfer and distribution of nicotine in the pregnant rhesus monkey

Cited by 78 publications

References 2 publications

Maternal Nicotine Exposure and Carbohydrate Metabolism of Fetal and Neonatal Lung Tissue: Response to Nicotine Withdrawal

Maternal Nicotine Exposure and Carbohydrate Metabolism of Fetal and Neonatal Lung Tissue: Response to Nicotine Withdrawal

Transgenerational Effects of Maternal Nicotine Exposure During Gestation and Lactation on the Respiratory System

Smoking among pregnant women - epidemiology and health consequences

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