Placental Transfer and Fetal Tissue Uptake of Mg28 in the Rabbit

Aikawa, Jerry K.; Bruns, Paul D.; Reardon, Jacqueline Z.; Harms, Dale R.; Linder, Robert O.

doi:10.3181/00379727-105-26020

Cited by 26 publications

(10 citation statements)

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“…The results demonstrated that there was a strong positive correlation between maternal serum and cord blood magnesium levels (r = 0.95, P < 0.001) and both were also correlated significantly with total dose and duration of MgSO 4 administered. A previous study revealed that tagged magnesium was actively concentrated in the placenta of the pregnant rabbit, and was rapidly taken up by fetal tissues 17 . A similar mechanism might also occur in humans, which would account for high cord blood magnesium levels similar to what was found in this study.…”

Section: Discussionsupporting

confidence: 86%

Correlation of magnesium levels in cord blood and maternal serum among pre‐eclamptic pregnant women treated with magnesium sulfate

Boriboonhirunsarn¹,

Lertbunnaphong²,

Suwanwanich³

2011

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 86%

Correlation of magnesium levels in cord blood and maternal serum among pre‐eclamptic pregnant women treated with magnesium sulfate

Boriboonhirunsarn¹,

Lertbunnaphong²,

Suwanwanich³

2011

J of Obstet and Gynaecol

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“…At cord Mg concentrations between 4 and 11 mg/dl, respiratory depression and motor depression have been observed. Clinically, serum Mg concentration in newborn infants usually exceeds maternal levels and leads to hypermagnesemia, with cord concentrations 70-100% higher than the maternal levels [19,[22][23][24] . Our study showed an initial rapid increase in the maternal magnesium concentration followed by a gradual increase in the fetal Mg concentration during the 3 h after MgSO 4 administration.…”

Section: Discussionmentioning

confidence: 99%

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Toyoshima¹,

Momma²,

Nakanishi³

2009

Neonatology

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Background: Magnesium sulfate (MgSO₄) is used therapeutically for eclampsia and tocolysis. Some reports have suggested a relationship between therapeutic MgSO₄ and patent ductus arteriosus (DA) in preterm infants. Objectives: To clarify patent DA induction by MgSO₄ in preterm infants, we studied the increase in serum Mg concentrations and fetal dilatation and postnatal delayed closure of the ductus, using transplacental MgSO₄ in rats. Methods: Fetal and neonatal ductus diameters were measured with a microscope and a micrometer after rapid whole-body freezing. In the postnatal study, 21-day pregnant dams were administered a subcutaneous injection of MgSO₄ 1–3 h before delivery, and the ductus was studied 0, 15, 30, 60 and 120 min after birth. In the fetal study, MgSO₄ (1 g/kg) and indomethacin (10 mg/kg) were simultaneously administered to 21-day dams and the fetal ductus was studied 1, 2 and 4 h later. Serum Mg concentration was measured in the dams and newborns. Results: Neonatal Mg concentrations increased from 3.8 to 4.7 and 5.8 mg/dl at 1 and 3 h after maternal administration of MgSO₄. Following MgSO₄ administration 3 h before birth, closure of the neonatal DA was delayed. The ductus diameter was 0.88 mm (0.80 mm in control) at 0 min, and 0.26 mm (0.08 mm in the control) at 60 min after birth. In the fetal study, MgSO₄ initially reversed and later attenuated the ductus-constricting effect of indomethacin. Conclusions: Hypermagnesemia induced by transplacental MgSO₄ attenuates the fetal ductus-constricting effects of indomethacin, and delays postnatal ductal closure in rats.

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“…The etiology of this impairment is unclear, but it has been suggested that the Mg-dependent enzyme adenyl cyclase plays a central role [28,29]. Transfer of Mg from mother to fetus ap pears to be an active ATPase-dependent transport process [30].…”

Section: Discussionmentioning

confidence: 98%

A role for magnesium in neonatal parathyroid gland function?

Loughead

Mimouni

Tsang

1991

Journal of the American College of Nutrition

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Little is known of the factors regulating parathyroid function in the neonatal period. Twenty-seven term infants born after uncomplicated pregnancies, labors, and deliveries were studied to test the hypothesis that in normal newborns the amplitude of parathyroid hormone (PTH) response to decreasing serum ionized calcium (iCa) correlates with serum magnesium (Mg) concentrations. Serum iCa (ion selective electrode, Radiometer ICA 1), PTH (1-84 intact molecules, radioimmunoassay) and Mg (atomic absorption) were measured at birth (cord blood) and 24 hours of age. Repeated measures analysis of covariance showed decreasing serum iCa (p less than 0.01) and increasing serum Mg (p less than 0.01) and PTH (p less than 0.01) over time. The change in PTH over the first 24 hours was directly correlated with cord blood (r = 0.38, p less than 0.05) and 24-hr Mg concentrations (r = 0.53, p less than 0.01). We conclude that the ability of the parathyroid gland to respond to decreasing serum iCa after birth is directly related to Mg status. We speculate that neonatal hypomagnesemia may lead to a blunted PTH secretory response, thus contributing to early neonatal hypocalcemia.

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Placental Transfer and Fetal Tissue Uptake of Mg28 in the Rabbit

Cited by 26 publications

References 0 publications

Correlation of magnesium levels in cord blood and maternal serum among pre‐eclamptic pregnant women treated with magnesium sulfate

Correlation of magnesium levels in cord blood and maternal serum among pre‐eclamptic pregnant women treated with magnesium sulfate

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

A role for magnesium in neonatal parathyroid gland function?

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