Placentation in the Fallopian Tube

Randall, Sarah; Ch, Buckley; Fox, H.

doi:10.1097/00004347-198706000-00005

Cited by 68 publications

(18 citation statements)

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“…4 a–c). Extravillous trophoblasts in tubal pregnancies have already been described to invade vessels (Li et al 2015 ; Randall et al 1987 ), while single cells can also be found in the lumen of the vessels (Fig. 4 d).…”

Section: First Insight Into Alterations Of the Migratory Routes Of Exmentioning

confidence: 64%

Human trophoblast invasion: new and unexpected routes and functions

Moser

Windsperger

Pollheimer

et al. 2018

Histochem Cell Biol

135

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Until recently, trophoblast invasion during human placentation was characterized by and restricted to invasion into uterine connective tissues and the uterine spiral arteries. The latter was explained to connect the arteries to the intervillous space of the placenta and to guarantee the blood supply of the mother to the placenta. Today, this picture has dramatically changed. Invasion of endoglandular trophoblast into uterine glands, already starting at the time of implantation, enables histiotrophic nutrition of the embryo prior to perfusion of the placenta with maternal blood. This is followed by invasion of endovenous trophoblasts into uterine veins to guarantee the drainage of fluids from the placenta back into the maternal circulation throughout pregnancy. In addition, invasion of endolymphatic trophoblasts into the lymph vessels of the uterus has been described. Only then, invasion of endoarterial trophoblasts into spiral arteries takes place, enabling hemotrophic nutrition of the fetus starting with the second trimester of pregnancy. This new knowledge paves the way to identify changes that may occur in pathological pregnancies, from tubal pregnancies to recurrent spontaneous abortions.

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Section: First Insight Into Alterations Of the Migratory Routes Of Exmentioning

confidence: 64%

Human trophoblast invasion: new and unexpected routes and functions

Moser

Windsperger

Pollheimer

et al. 2018

Histochem Cell Biol

135

View full text Add to dashboard Cite

show abstract

“…It has been pointed out that trophoblast cells in tubal pregnancy appear morphologically and physiologically similar to those found at normal intrauterine implantation sites [23]. Also, the placentation occurring in the fallopian tube is identical to that in the uterus [24]. Thus, tubal pregnancy provides a unique model for studying the function of trophoblast cells during early gestation.…”

Section: Discussionmentioning

confidence: 98%

Expression of P450 aromatase and 17β-hydroxysteroid dehydrogenase type 1 at fetal–maternal interface during tubal pregnancy

Qin

Zhi

et al. 2003

The Journal of Steroid Biochemistry and Molecular Biology

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“…Although placentation is relatively similar in ectopic and intrauterine pregnancies, there are certain differences such as the absence of decidua formation by the tube and the impossibility of trophoblast formation and differentiation within the tube [18]. We hypothesize that there is a decreased blood supply in ectopic pregnancy, which may affect the transport of EVTB into the maternal circulation, with a subsequent decrease in levels of mRNA in maternal plasma.…”

Section: Discussionmentioning

confidence: 99%

Placental mRNA in maternal plasma as a predictor of ectopic pregnancy

Takács

Jaramillo

Datar

et al. 2012

International Journal of Gynecology & Obstetrics

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Objective To measure and compare placental mRNA expression in the maternal circulation among women with intrauterine and ectopic pregnancies. Methods Plasma was collected from patients in early pregnancy at risk of ectopic pregnancy. Clinical information was prospectively collected and entered into a dedicated database. mRNA was isolated from maternal plasma and quantitative RT-PCR was performed to measure mRNA for human gonadotropin (hCG) and human placental lactogen (hPL). GAPDH mRNA expression was used as an internal control. Results Twelve women with ectopic pregnancy and 13 women with intrauterine pregnancy were enrolled. Patients with ectopic pregnancy were 6 times more likely to have undetectable levels of hPL mRNA (relative risk [RR] 6.36; 95% confidence interval [CI], 1.70–23.20; P<0.01). They were also 8 times more likely to have undetectable levels of hCG mRNA (RR 8.64, 95% CI, 1.30–57.10; P<0.01). mRNA copy numbers for hPL and hCG (normalized by GAPDH) were significantly lower in the ectopic group than in the intrauterine group. Conclusion Placental mRNA is present in the maternal circulation in significantly lower copies in cases of ectopic pregnancy compared with cases of intrauterine pregnancy. Measurement of placental mRNA in the maternal circulation may help to distinguish between intrauterine and ectopic pregnancies.

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Placentation in the Fallopian Tube

Cited by 68 publications

References 0 publications

Human trophoblast invasion: new and unexpected routes and functions

Human trophoblast invasion: new and unexpected routes and functions

Expression of P450 aromatase and 17β-hydroxysteroid dehydrogenase type 1 at fetal–maternal interface during tubal pregnancy

Placental mRNA in maternal plasma as a predictor of ectopic pregnancy

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