Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases

Wu, Gang; Ge, Jiao; Huang, Xupei; Hua, Yimin; Mu, Dezhi

doi:10.1155/2011/589414

Cited by 21 publications

(16 citation statements)

References 99 publications

(154 reference statements)

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“…PCP, to promote cell migration and convergent extension movements. 2,189,192,193,196 The link between Wnt signaling and the primary cilium is highly controversial. 32,35,197 However, many Wnt signaling components, such as Fz3, Dvl, and β-catenin, localize to the ciliary/centrosomal axis, and dysregulated Wnt signaling has been reported in cells and tissues with disrupted ciliogenesis or basal body integrity.…”

Section: Cardiac Primary Cilia and Other Signaling Pathwaysmentioning

confidence: 99%

“…2,189 Mutations in Vangl2 disrupt migration of cells into the OFT and this is associated with impaired OFT myocardialization as well as ventricular and OFT septal defects. 189 The localization of Vangl2 during heart development is dependent on Scribble, another PCP component, 204 and in agreement with this, Scribble phenotypes are reminiscent of Vangl2 mutants.…”

Section: Cardiac Primary Cilia and Other Signaling Pathwaysmentioning

confidence: 99%

“…Despite increasing knowledge and therapeutic advances, CHD causes 10% of all noninfectious infant deaths within the first year of life. 2,3 The spectrum of CHD is broad and patients may have more than one heart abnormality. CHD can be characterized by multifaceted morphological and structural abnormalities including septal and valve defects, tetralogy of Fallot (TOF) and arterial transposition.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 CHD prognosis and mortality depend on the size, number, and type of defect(s) and the associated abnormalities. 2 An overview of common types of heart defects and their morphological characteristics is given in Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Cilia and coordination of signaling networks during heart development

et al. 2013

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Section: Cardiac Primary Cilia and Other Signaling Pathwaysmentioning

confidence: 99%

Section: Cardiac Primary Cilia and Other Signaling Pathwaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cilia and coordination of signaling networks during heart development

et al. 2013

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“…Disturbances in PCP signaling produce developmental anomalies in neural tube closure, left-right asymmetry, and hair cell orientation in the inner ear (14)(15)(16)(17)(18)(19)(20). In humans, mutations or polymorphisms of PCP components are associated with an array of developmental defects including spina bifida, cardiac outflow malformations, and cystic renal disease (21)(22)(23)(24).…”

Section: Significancementioning

confidence: 99%

Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation

Yuan

Cha

Deng

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Blastocyst implantation is a complex process requiring coordination of a dynamic sequence of embryo-uterine interactions. Blood vessels enter the uterus from the mesometrium, demarcating the uterus into mesometrial (M) and antimesometrial (AM) domains. Implantation occurs along the uterine longitudinal axis within specialized implantation chambers (crypts) that originate within the evaginations directed from the primary lumen toward the AM domain. The morphological orientation of crypts in rodent uteri was recognized more than a century ago, but the mechanism remained unknown. Here we provide evidence that planar cell polarity (PCP) signaling orchestrates directed epithelial evaginations to form crypts for implantation in mice. Uterine deletion of Vang-like protein 2, but not Vang-like protein 1, conferred aberrant PCP signaling, misdirected epithelial evaginations, defective crypt formation, and blastocyst attachment, leading to severely compromised pregnancy outcomes. The study reveals a previously unrecognized role for PCP in executing spatial cues for crypt formation and implantation. Because PCP is an evolutionarily conserved phenomenon, our study is likely to inspire implantation studies of this signaling pathway in humans and other species.ffective reciprocal cross-talk between the receptive uterus and a competent blastocyst is critical for successful implantation (1). In nearly all mammals studied, the uterus differentiates into a receptive state timed appropriately with the migration of blastocysts into the uterus to initiate bidirectional communication for implantation. The receptive state is transient; in mice the uterus becomes receptive on day 4 of pregnancy (day 1 = vaginal plug) and refractory to implantation by the afternoon of day 5 (2). The coordinated actions of progesterone and estrogen regulate the proliferation and/or differentiation of major uterine cell types in a spatiotemporal manner to establish this brief window of receptivity for implantation. These changes involve an interplay of ovarian hormones, transcription factors, growth factors, morphogens, cytokines, and other signaling molecules. Aberrations or defects in any of these pathways may result in implantation failure or defective implantation, which propagates adverse ripple effects through the remaining course of gestation, compromising pregnancy outcomes (2-5).Blood vessels enter the uterus from the mesometrium and delineate the uterus into mesometrial (M) and antimesometrial (AM) domains. In mice, blastocyst attachment occurs within specialized crypts (implantation chambers), which originate as epithelial evaginations from the main lumen at orderly spaced intervals at the AM domain. The formation of these directed evaginations is initiated on the morning of day 3, and they elongate by the afternoon of day 4 for blastocyst attachment and subsequent crypt formation in the evening along the Wnt5a gradient (6). Blastocyst attachment coincides with increased endometrial vascular permeability at the site of the attachment, which can...

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Apico-basal polarity complex and cancer

Khursheed

Bashyam

2014

J Biosci

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Apico-basal polarity is a cardinal molecular feature of adult eukaryotic epithelial cells and appears to be involved in several key cellular processes including polarized cell migration and maintenance of tissue architecture. Epithelial cell polarity is maintained by three well-conserved polarity complexes, namely, PAR, Crumbs and SCRIB. The location and interaction between the components of these complexes defines distinct structural domains of epithelial cells. Establishment and maintenance of apico-basal polarity is regulated through various conserved cell signalling pathways including TGF beta, Integrin and WNT signalling. Loss of cell polarity is a hallmark for carcinoma, and its underlying molecular mechanism is beginning to emerge from studies on model organisms and cancer cell lines. Moreover, deregulated expression of apico-basal polarity complex components has been reported in human tumours. In this review, we provide an overview of the apico-basal polarity complexes and their regulation, their role in cell migration, and finally their involvement in carcinogenesis.

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Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases

Cited by 21 publications

References 99 publications

Cilia and coordination of signaling networks during heart development

Cilia and coordination of signaling networks during heart development

Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation

Apico-basal polarity complex and cancer

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