Planar‐/Curvilinear‐Bioprinted Tri‐Cell‐Laden Hydrogel for Healing Irregular Chronic Wounds

Wu, Shin‐Da; Dai, Niann‐Tzyy; Liao, Chao-Yaug; Kang, Lan-Ya; Tseng, Yi‐Ping; Hsu, Shan‐hui

doi:10.1002/adhm.202201021

Cited by 21 publications

(15 citation statements)

References 69 publications

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“…In a recent study by Wang et al, a hydrogel composed of sodium alginate and plateletrich plasma was fabricated [52]. The hydrogel itself offers additional advantages in wound healing as it sustains moist conditions at the wound site [52,54]. By comparison, the wound healing capability of the Zn-NA MOFs in this work proved to be higher than the alginate-based hydrogel [52].…”

Section: In Vivo Wound Healing Assaymentioning

confidence: 72%

Facile synthesis of zinc acetate/niacin MOFs for use in wound healing

Ashmawy,

Azzazy

2023

Biomed. Mater.

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Niacin (NA) and Zinc (Zn) were used to fabricate metal organic frameworks (Zn-NA MOFs), based on coordination chemistry via a simple, rapid technique conducted at room temperature. The identity of the prepared MOFs was confirmed by FTIR, XRD, SEM, and TEM, which showed cubic shaped, crystalline, microporous MOFs with an average size of 150 nm. Release of the active ingredients from the MOFs was proved to be pH dependent in a slightly alkaline medium (pH 8.5) with a sustained release rate of its two ingredients, NA and Zn, which have wound healing activity. Zn-NA MOFs proved to be biocompatible in the tested concentrations range (5 - 100 mg/mL), with no cytotoxic effect on WI-38 cell line. Zn-NA MOFs at 10 and 50 mg/mL concentrations and their components, NA and Zn, exerted antibacterial effects against S. aureus, E. coli, and P. aeruginosa. Wound healing effect of the Zn-NA MOFs (50 mg/mL) was evaluated on full excisional rat wounds. Significant reduction of the wound area was observed after 9 days of treatment using the Zn-NA MOFs compared to the other treatment groups. Additionally, wounds were fully healed after 10 days of treatment with the Zn-NA MOFs with histological and immunohistochemical evidence of re-epithelization, collagen formation, and angiogenesis. Similar histological evidence was also observed in wounds treated with niacin only; however, with no significant wound closure rates. Nevertheless, the formation of new blood vessels, as confirmed by the VEGF protein expression, was highest in the niacin group. Zn-NA MOFs synthesized using a facile, low-cost method are potentially capable of healing wounds rapidly and effectively. 

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Section: In Vivo Wound Healing Assaymentioning

confidence: 72%

Facile synthesis of zinc acetate/niacin MOFs for use in wound healing

Ashmawy,

Azzazy

2023

Biomed. Mater.

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“…After implanted into the wound beds, the 3D multicellular constructs could facilitate re-epithelization, dermal ECM secretion, vascularization and accelerate wound healing process. Wu et al [ 72 ] developed curvilinear-bioprintable scaffolds loading three types of cells (fibroblasts, keratinocytes, and endothelial progenitor cells (EPCs)) to treat chronic wounds with irregular shape. After treating the large and irregular rat skin wounds for 28 days, the bioprinted tri-cell-laden scaffolds obviously promoted reepithelization and dermal repair as well as neovascularization and collagen production of the defects.…”

Section: D Cells Bioprinted Scaffolds For Tissue Regenerationmentioning

confidence: 99%

3D printing of cell-delivery scaffolds for tissue regeneration

Xue

Chen

2023

Regenerative Biomaterials

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Tissue engineering strategy that combine biomaterials with living cells has shown special advantages in tissue regeneration and promoted the development of regenerative medicine. In particular, the rising of 3D printing technology further enriched the structural design and composition of tissue engineering scaffolds, which also provided convenience for cell loading and cell delivery of living cells. In this review, two types of cell-delivery scaffolds for tissue regeneration, including 3D printed scaffolds with subsequent cell-seeding and 3D cells-bioprinted scaffolds, are mainly reviewed. We devote a major part to present and discuss the recent advances of two 3D printed cell-delivery scaffolds in regeneration of various tissues, involving bone, cartilage, skin tissues and so on. Although two types of 3D printed cell-delivery scaffolds have some shortcomings, they do have generally facilitated the exploration of tissue engineering scaffolds in multiple tissue regeneration. It is expected that 3D printed cell-delivery scaffolds will be further explored in function mechanism of seeding cells in vivo, precise mimicking of complex tissues and even organ reconstruction under the cooperation of multiple fields in future.

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“…16,17 Additionally, the irregular nature of diabetic wounds poses further impediments to effective healing. 18 Therefore, there is a pressing demand for an innovative smart hydrogel adapted to the complex microenvironment of diabetic wounds that can fulfill the intricate demands of diabetic wound healing and seamlessly adapt to the complexities posed by irregular wounds.…”

Section: Introductionmentioning

confidence: 99%