Consistent and optimized territorial planning, imply the use of numerous variables aimed at improving life quality and reduction of environmental impacts. The resilience of the territory to climate change threats is strongly linked to its progressive transformation. This fact is extremely evident in coastal systems, which are intrinsically fragile systems due to their high environmental value and strong anthropogenic pressure. The existing tools and techniques provide to outline future transformation effects through the scenarios analysis. This work has the objective to evaluate the effects of land use changes in the territory of the Abruzzo coast. The conversion from natural soils to artificial uses has a significant impact on several ecosystem services. The regulation services considered in this work are flood regulation, carbon storage and sequestration, and habitat for biodiversity. The first is directly connected to soil sealing which determines a reduction of water infiltration with the consequent overloading of the existing sewerage systems. The quantitative evaluation is made using the concept of surface runoff coefficient. Instead, the estimation of the last two ecosystem services has been made using InVEST (Integrated Valuation of Ecosystem Services and Tradeoffs) models, specifically the Carbon Storage and Sequestration model and the Habitat Quality model. The results show that Land Use Changes (2012–2018) caused a potential increase of 10% in runoff and an annual Carbon Sequestration loss estimated at about € 820,000.