Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon

Hill, Nigel; Lenglet, Annick; Arnez, Abrahan Matias; Carneiro, Ilona

doi:10.1136/bmj.39356.574641.55

Cited by 117 publications

(156 citation statements)

References 10 publications

Supporting

Mentioning

154

Contrasting

Order By: Relevance

“…10 A study in Bolivia found a highly significant 80% reduction in episodes of Plasmodium vivax in the group that used treated nets and repellent (incidence rate ratio 0.20, 95% CI, 0.11 to 0.38, P 0.001). 26 In areas where vectors feed in the early evening, effectiveness of treated nets can be significantly increased by using repellent between dusk and bedtime. In Ghana, An.…”

Section: Discussionmentioning

confidence: 99%

A Community-Wide Study of Malaria Reduction: Evaluating Efficacy and User-Acceptance of a Low-Cost Repellent in Northern Ghana

Dadzie

Boakye²,

Asoala³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. NO MAS (NM) mosquito repellent was evaluated in two farming villages (4 km apart) in the Kassena Nankana district of northern Ghana. We determined its efficacy against local malaria vectors, degree of user acceptance, and its effect on malaria prevalence in households using insecticide-treated bed nets. The average protective efficacy of NM against Anopheles mosquitoes over 9 hours was 89.6%. Controls averaged 86 bites/person/night versus 9 bites/ person/night with the use of NM. Use of repellent was associated with a decrease of absolute malaria prevalence by 19.2% in the repellent village and by 6.5% in the control village (45.5 to 26.3, and 29.5 to 23.0, respectively). The useracceptance rate of NM repellent was 96.1%. Ten percent (10%) of repellent users reported irritation as the main adverse effect during the period. Eighty-five percent (85%) of the users found the odor of NM appealing and 87% reported no inconvenience in applying the repellent daily.

show abstract

Section: Discussionmentioning

confidence: 99%

A Community-Wide Study of Malaria Reduction: Evaluating Efficacy and User-Acceptance of a Low-Cost Repellent in Northern Ghana

Dadzie

Boakye²,

Asoala³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Spatial repellency has nonetheless been well documented under experimental conditions. [12][13][14][15][16] Adopting SR as a broad prevention strategy, however, requires more practical demonstrations of impact. The current study aimed to provide limited proof-of-concept evidence of SRmediated reduction of malaria transmission in communities naturally exposed to the pathogen.…”

Section: Introductionmentioning

confidence: 99%

Impact of a Spatial Repellent on Malaria Incidence in Two Villages in Sumba, Indonesia

Syafruddin¹,

Bangs²,

Sidik³

et al. 2014

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. A randomized, double-blinded, placebo-controlled study was conducted to examine the effect of spatial repellent (SR) in households at risk of malaria in Indonesia. Following presumptive radical cure for malaria in 180 adult men representing sentinels of new infection in four clusters within two villages, all households were given either metofluthrin or placebo mosquito coils. Weekly blood smear screening and human-landing mosquito catches were done throughout the 6 months intervention. Malaria infections occurred in 61 subjects living in placebo households and 31 subjects living in SR coil households, suggesting a 52% protective effect of SR. Likewise, anopheles indoor human landing rates were 32% lower in homes receiving SR coils. Differences in the malaria attack rate between SR-and placebo-treated homes was significant when not accounting for the effects of clustering. When the analysis was adjusted for intra-cluster correlation, the differences between SR-and placebo-treated homes were not statistically significant. The findings provide evidence of SR public health benefit and support a larger trial statistically powered to detect those effects.

show abstract

“…The positive impact of the synergistic action of PMD with insecticide (deltamethrin) treated bed nets in preventing malaria has been reported from Bolivian Amazon by Hill et al [78]. Field study reports from Bolivia and Tanzania using topical application of 20% PMD have reported successful repellent activity against mosquitoes up to 4-6 hrs.…”

Section: Field Trialsmentioning

confidence: 84%

Evolution, Current Status and Prospects of Phyto-Repellents against Mosquitoes

Bhat¹,

Aravind

2017

IJPPE

View full text Add to dashboard Cite

Mosquitoes enjoy wide geographical distribution and act as vectors for diverse pathogenic organisms from viruses to protozoans. Mosquito-borne diseases have a long history with some of them like Malaria dominating the scene for centuries. New diseases like Dengue fever, Zika viral disease etc. get added to the list from time to time. Vector control is an effective and widely accepted strategy in the management of mosquito-borne diseases. Mosquito repellents are an important product range extensively used for the management of mosquito-borne diseases. The research and development activities on mosquito repellents of plant origin have been reviewed in this article and classified into three categories like research reports, patents and commercial products, based on their outcomes. The relevance of plant-based mosquito repellents is discussed with reference to current societal and market trends. The review has revealed an increasing trend among researchers towards product development and entry of effective and innovative products into the market. The market analysis reports also confirm competitive advantage for herbal repellents in the coming years.

show abstract

Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon

Cited by 117 publications

References 10 publications

A Community-Wide Study of Malaria Reduction: Evaluating Efficacy and User-Acceptance of a Low-Cost Repellent in Northern Ghana

A Community-Wide Study of Malaria Reduction: Evaluating Efficacy and User-Acceptance of a Low-Cost Repellent in Northern Ghana

Impact of a Spatial Repellent on Malaria Incidence in Two Villages in Sumba, Indonesia

Evolution, Current Status and Prospects of Phyto-Repellents against Mosquitoes

Contact Info

Product

Resources

About