Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx

Jiang, Zhi; Zhou, Xiaoping; Tao, Ming; Yuan, Fang; Liu, Lulu; Wu, Fei-Hua; Wu, Xiaomei; Xiang, Yun; Niu, Yue; Liu, Feng; Li, Chijun; Rui, Yong; Byeon, Benjamin; Xue, Yan; Zhao, Hongyan; Wang, Hsin‐Neng; Crawford, Bridget M.; Johnson, Douglas M.; Hu, Chanxing; Pei, Christopher; Wenming, Zhou; Swift, Gary B.; Zhang, Han; Vo‐Dinh, Tuan; Hu, Zhangli; Siedow, James N.; Pei, Zhe

doi:10.1038/s41586-019-1449-z

Cited by 414 publications

(345 citation statements)

References 89 publications

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“…Our understanding of how plants modulate ABA accumulation in response to environmental stresses would be greatly facilitated by the identification of stress sensors. Although several putative sensors of salt, cold, and osmotic stresses have been identified, the mechanisms that link environmental sensing to ABA accumulation remains largely unknown (Yuan et al 2014; Ma et al 2015; Jiang et al 2019). Therefore, understanding the regulation of ABA dynamics requires more knowledge of the upstream stress sensing and signaling events.…”

Section: Perspectivesmentioning

confidence: 99%

Abscisic acid dynamics, signaling, and functions in plants

Chen

Bressan

et al. 2020

JIPB

1,026

628

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Abscisic acid (ABA) is an important phytohormone regulating plant growth, development, and stress responses. It has an essential role in multiple physiological processes of plants, such as stomatal closure, cuticular wax accumulation, leaf senescence, bud dormancy, seed germination, osmotic regulation, and growth inhibition among many others. Abscisic acid controls downstream responses to abiotic and biotic environmental changes through both transcriptional and posttranscriptional mechanisms. During the past 20 years, ABA biosynthesis and many of its signaling pathways have been well characterized. Here we review the dynamics of ABA metabolic pools and signaling that affects many of its physiological functions.

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Section: Perspectivesmentioning

confidence: 99%

Abscisic acid dynamics, signaling, and functions in plants

Chen

Bressan

et al. 2020

JIPB

1,026

628

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“…For example, under salt stress, both the composition of the cell wall changes and PM‐localized leucine‐rich repeat receptor kinases (LRR‐RKs) proteins sense the cell wall integrity (CWI) thereby contributing to the perception of salt signaling (Yang and Guo 2018). Moreover, it has been recently found that a PM lipid glycosyl inositol phosphorylceramide (GIPC) binds Na + and controls Ca 2+ influx channels (Jiang et al 2019). Salt stress perceived by multiple pathways further activates the salt overly sensitive (SOS) pathway including SOS2 kinase and PM‐localized SOS1 Na + antiporter to export excessive Na + out of the cell, facilitating plant survival, and growth (Yang and Guo 2018).…”

Section: Introductionmentioning

confidence: 99%

The roles of endomembrane trafficking in plant abiotic stress responses

Wang

Gao

et al. 2020

JIPB

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Endomembrane trafficking is a fundamental cellular process in all eukaryotic cells and its regulatory mechanisms have been extensively studied. In plants, the endomembrane trafficking system needs to be constantly adjusted to adapt to the ever-changing environment. Evidence has accumulated supporting the idea that endomembrane trafficking is tightly linked to stress signaling pathways to meet the demands of rapid changes in cellular processes and to ensure the correct delivery of stress-related cargo molecules. However, the underlying mechanisms remain unknown. In this review, we summarize the recent findings on the functional roles of both secretory trafficking and endocytic trafficking in different types of abiotic stresses. We also highlight and discuss the unique properties of specific regulatory molecules beyond their conventional functions in endosomal trafficking during plant growth under stress conditions.

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“…Under physical damage, pathogen attack or other stresses, Ca 2+ fluxes from these stores can produce different local Ca 2+ concentrations to activate metacaspases such as AtMC4 to initiate different extents of self-cleavage for the appropriate immune responses 4,27,28 . We thus propose that metacaspases function as a Ca 2+ -signature decoder to transduce Ca 2+ signals to activate distinct response pathways.…”

Section: Discussionmentioning

confidence: 99%

Structural Basis for Ca²⁺-Dependent Activation of a Plant Metacaspase

Zhu

Wang

et al. 2020

Preprint

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AbstractPlants metacaspases mediate programmed cell death in development 1,2, biotic and abiotic stresses 3, damage-induced immune response 4, and resistance to pathogen attack 5. Most metacaspases require Ca2+ for their activation and substrate processing 6–8. However, the Ca2+-dependent activation mechanism remains elusive 9–11. Here we report the crystal structure of Metacaspase 4 from Arabidopsis thaliana (AtMC4) that modulates Ca2+-dependent, damage-induced plant immune defense. The AtMC4 structure exhibits an inhibitory conformation in which a large linker domain blocks activation and substrate access. In addition, the side chain of Lys225 in the linker domain blocks the active site by sitting directly between two catalytic residues. We show that the activation of AtMC4 and cleavage of its physiological substrate involve multiple cleavages in the linker domain upon activation by Ca2+. Our analysis provides insight into the Ca2+-dependent activation of AtMC4 and lays the basis for tuning its activity in response to stresses that may help engineer more sustainable crops for production of food and biofuel.

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Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx

Cited by 414 publications

References 89 publications

Abscisic acid dynamics, signaling, and functions in plants

Abscisic acid dynamics, signaling, and functions in plants

The roles of endomembrane trafficking in plant abiotic stress responses

Structural Basis for Ca²⁺-Dependent Activation of a Plant Metacaspase

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Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx

Cited by 414 publications

References 89 publications

Abscisic acid dynamics, signaling, and functions in plants

Abscisic acid dynamics, signaling, and functions in plants

The roles of endomembrane trafficking in plant abiotic stress responses

Structural Basis for Ca2+-Dependent Activation of a Plant Metacaspase

Contact Info

Product

Resources

About

Structural Basis for Ca²⁺-Dependent Activation of a Plant Metacaspase