Plant D–type cyclins and the control of G1 progression

Oakenfull, E. Ann; Riou, Catherine; Murray, James A. H.

doi:10.1098/rstb.2002.1085

Cited by 113 publications

(101 citation statements)

References 94 publications

(130 reference statements)

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“…In a complex with CDKA, the D-type cyclin regulates the G1/ S-phase transition (Oakenfull et al, 2002). Transcripts of Pp CYCD;1 and Pp CYCD;2 accumulated between 6 and 48 h after cutting (Figures 2A and 2B).…”

Section: Rbr;3) Inhibitor/interactor Of Cyclin-dependent Kinase (Ickmentioning

confidence: 99%

PhyscomitrellaCyclin-Dependent Kinase A Links Cell Cycle Reactivation to Other Cellular Changes during Reprogramming of Leaf Cells

et al. 2011

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During regeneration, differentiated plant cells can be reprogrammed to produce stem cells, a process that requires coordination of cell cycle reactivation with acquisition of other cellular characteristics. However, the factors that coordinate the two functions during reprogramming have not been determined. Here, we report a link between cell cycle reactivation and the acquisition of new cell-type characteristics through the activity of cyclin-dependent kinase A (CDKA) during reprogramming in the moss Physcomitrella patens. Excised gametophore leaf cells of P. patens are readily reprogrammed, initiate tip growth, and form chloronema apical cells with stem cell characteristics at their first cell division. We found that leaf cells facing the cut undergo CDK activation along with induction of a D-type cyclin, tip growth, and transcriptional activation of protonema-specific genes. A DNA synthesis inhibitor, aphidicolin, inhibited cell cycle progression but prevented neither tip growth nor protonemal gene expression, indicating that cell cycle progression is not required for acquisition of protonema cell-type characteristics. By contrast, treatment with a CDK inhibitor or induction of dominant-negative CDKA;1 protein inhibited not only cell cycle progression but also tip growth and protonemal gene expression. These findings indicate that cell cycle progression is coordinated with other cellular changes by the concomitant regulation through CDKA;1.

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Section: Rbr;3) Inhibitor/interactor Of Cyclin-dependent Kinase (Ickmentioning

confidence: 99%

PhyscomitrellaCyclin-Dependent Kinase A Links Cell Cycle Reactivation to Other Cellular Changes during Reprogramming of Leaf Cells

et al. 2011

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“…Auxin is essential for cell division and expansion in vitro and has been used widely in cell culture and plant regeneration in concert with cytokinin. The expression of mitotic genes, including CycD3;1 and CDKA;1, has been found to be regulated by auxin (Hemerly et al, 1993;Doerner et al, 1996;Oakenfull et al, 2002). At the wholeplant level, some auxin mutants display a dramatic alteration in aerial organ development.…”

Section: Argos Mediates the Auxin Signal To Affect Lateral Organ Devementioning

confidence: 99%

The Arabidopsis Auxin-Inducible Gene ARGOS Controls Lateral Organ Size

2003

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“…Analysis of CYCD -related genes in the Arabidopsis genome shows 10 genes that fall into six or seven groups (Oakenfull et al, 2002;Vandepoele et al, 2002), most of which have not been analyzed in detail. The CYCD3 group includes three genes, of which CYCD3;1 is the best studied.…”

Section: Introductionmentioning

confidence: 99%

Altered Cell Cycle Distribution, Hyperplasia, and Inhibited Differentiation in Arabidopsis Caused by the D-Type Cyclin CYCD3

et al. 2002

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CYCD3;1 expression in Arabidopsis is associated with proliferating tissues such as meristems and developing leaves but not with differentiated tissues. Constitutive overexpression of CYCD3;1 increases CYCD3;1-associated kinase activity and reduces the proportion of cells in the G1-phase of the cell cycle. Moreover, CYCD3;1 overexpression leads to striking alterations in development. Leaf architecture in overexpressing plants is altered radically, with a failure to develop distinct spongy and palisade mesophyll layers. Associated with this, we observe hyperproliferation of leaf cells; in particular, the epidermis consists of large numbers of small, incompletely differentiated polygonal cells. Endoreduplication, a marker for differentiated cells that have exited from the mitotic cell cycle, is inhibited strongly in CYCD3;1 -overexpressing plants. Transcript analysis reveals an activation of putative compensatory mechanisms upon CYCD3;1 overexpression or subsequent cell cycle activation. These results demonstrate that cell cycle exit in the G1-phase is required for normal cellular differentiation processes during plant development and suggest a critical role for CYCD3 in the switch from cell proliferation to the final stages of differentiation.

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Plant D–type cyclins and the control of G1 progression

Cited by 113 publications

References 94 publications

PhyscomitrellaCyclin-Dependent Kinase A Links Cell Cycle Reactivation to Other Cellular Changes during Reprogramming of Leaf Cells

PhyscomitrellaCyclin-Dependent Kinase A Links Cell Cycle Reactivation to Other Cellular Changes during Reprogramming of Leaf Cells

The Arabidopsis Auxin-Inducible Gene ARGOS Controls Lateral Organ Size

Altered Cell Cycle Distribution, Hyperplasia, and Inhibited Differentiation in Arabidopsis Caused by the D-Type Cyclin CYCD3

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