Plant‐derived glucose transport inhibitors with potential antitumor activity

Shriwas, Pratik; Chen, Xiaozhuo; Kinghorn, A. Douglas; Ren, Yulin

doi:10.1002/ptr.6587

Cited by 18 publications

(10 citation statements)

References 121 publications

(147 reference statements)

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“…Plants are known to exhibit a huge repertoire of bioactive metabolites [436]. A significant number of reports on the capability of natural compounds with potential as anti-HIV agents have appeared during the last few decades.…”

Section: Discussionmentioning

confidence: 99%

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

et al. 2020

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Acquired Immunodeficiency Syndrome (AIDS), which chiefly originatesfroma retrovirus named Human Immunodeficiency Virus (HIV), has impacted about 70 million people worldwide. Even though several advances have been made in the field of antiretroviral combination therapy, HIV is still responsible for a considerable number of deaths in Africa. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. Presently, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate drugs derived from plants as well as their derivatives. Several plants, such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity. Here, weattempt to summarize the main results, which focus on the structures of most potent plant-based natural products having anti-HIV activity along with their mechanisms of action and IC50 values, structure-activity-relationships and important key findings.

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Section: Discussionmentioning

confidence: 99%

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

et al. 2020

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“…Many plant-derived glucose transport inhibitors have been found to show potential antitumor activity, and some of these may have use in addressing the management of toxicity and MDR observed with current anticancer drugs. 142 As discussed above, JKL B inhibited glycolysis in human NSCLC and mouse melanoma cells and showed antitumor activity, 131,135 and several of its analogues showed more potent tumor cell cytotoxicity than JKL B. Thus, the development of JKL B as a new anticancer agent by targeting GLUTs to lower side effects could be a promising future strategy, and this is supported by its high nontoxic i.p.…”

Section: ■ Diterpene Lactonesmentioning

confidence: 93%

Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones

Ren

Kinghorn

2020

J. Med. Chem.

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Naturally occurring terpenoid lactones and their synthetic derivatives have attracted increasing interest for their promising antitumor activity and potential utilization in the discovery and design of new antitumor agents. In the present perspective article, selected plant-derived five-membered γ-lactones and six-membered δ-lactones that occur with terpenoid scaffolds are reviewed, with their structures, cancer cell line cytotoxicity and in vivo antitumor activity, structure–activity relationships, mechanism of action, and the potential for developing cancer chemotherapeutic agents discussed in each case. The compounds presented include artemisinin (ART, 1), parthenolide (PTL, 2), thapsigargin (TPG, 3), andrographolide (AGL, 4), ginkgolide B (GKL B, 5), jolkinolide B (JKL B, 6), nagilactone E (NGL E, 7), triptolide (TPL, 8), bruceantin (BRC, 9), dichapetalin A (DCT A, 10), and limonin (LMN, 11), and their naturally occurring analogues and synthetic derivatives. It is hoped that this contribution will be supportive of the future development of additional efficacious anticancer agents derived from natural products.

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“…Phloretin can sensitize cancer cells to chemotherapeutic agents, such as daunorubicin, and mediates apoptosis to overcome drug resistance in colon cancer and leukemia cells in hypoxia [24]. In HepG2 xenografted mice, tumor growth was inhibited following combined treatment with phloretin and paclitaxel [25]. Phloretin inhibited proliferation and induced apoptosis in Calu-1, H838 and H520 cells and suppress the migration and invasion of NSCLC cells and enhanced the effect of cisplatin [26].…”

Section: Inhibitors Of Glucose Uptakementioning

confidence: 99%

Stable Isotope Tracing Metabolomics to Investigate the Metabolic Activity of Bioactive Compounds for Cancer Prevention and Treatment

Choudhury

Hackman

Lodi

et al. 2020

Cancers

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A major hallmark of cancer is the metabolic reprogramming of cancer cells to fuel tumor growth and proliferation. Various plant-derived bioactive compounds efficiently target the metabolic vulnerabilities of cancer cells and exhibit potential as emerging therapeutic agents. Due to their safety and common use as dietary components, they are also ideal for cancer prevention. However, to render their use as efficient as possible, the mechanism of action of these phytochemicals needs to be well characterized. Stable isotope tracing is an essential technology to study the molecular mechanisms by which nutraceuticals modulate and target cancer metabolism. The use of positionally labeled tracers as exogenous nutrients and the monitoring of their downstream metabolites labeling patterns enable the analysis of the specific metabolic pathway activity, via the relative production and consumption of the labeled metabolites. Although stable isotope tracing metabolomics is a powerful tool to investigate the molecular activity of bioactive compounds as well as to design synergistic nutraceutical combinations, this methodology is still underutilized. This review aims to investigate the research efforts and potentials surrounding the use of stable isotope tracing metabolomics to examine the metabolic alterations mediated by bioactive compounds in cancer.

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Plant‐derived glucose transport inhibitors with potential antitumor activity

Cited by 18 publications

References 121 publications

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones

Stable Isotope Tracing Metabolomics to Investigate the Metabolic Activity of Bioactive Compounds for Cancer Prevention and Treatment

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