Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

Joven, Jorge; Espinel, Eugènia; Rull, Anna; Aragonès, Gerard; Rodríguez-Gallego, Esther; Camps, Jordi; Micol, Vicente; Herranz-López, María; Menéndez, Javier A.; Borrás, Isabel; Segura‐Carretero, Antonio; Alonso-Villaverde, Carlos; Beltrán‐Debón, Raúl

doi:10.1016/j.bbagen.2012.03.020

Cited by 124 publications

(117 citation statements)

References 37 publications

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“…In LDL receptor knockout (LDLR −/− ) mice derived from a C57BL/6J background and fed a high-fat diet for 10 wk, increased expression of miR-103 and miR-107 was abolished by daily dosing of a mixture of concentrated plant-derived polyphenol compounds [22] , although weight gain and liver steatosis were ameliorated. The expression of miR-122 was not altered by the high fat diet, but was decreased by dietary polyphenols.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Micro RNAs in the development of non-alcoholic fatty liver disease

Gerhard

DiStefano

2014

WJH

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Nonalcoholic fatty liver disease or nonalcoholic fatty liver disease (NAFLD) refers to a group of disorders that arise from the accrual of fat in hepatocytes. Although various factors have been associated with the development of NAFLD, including genetic predisposition and environmental exposures, little is known about the underlying pathogenesis of the disease. Research efforts are ongoing to identify biological targets and signaling pathways that mediate NAFLD. Emerging evidence has implicated a role for micro RNAs (miRNAs), short single-stranded molecules that regulate gene expression either transcriptionally, through targeting of promoter regions, or post-transcriptionally, by blocking translation or promoting cleavage of specific target mRNAs. Several miRNAs have been associated with NAFLD, although our understanding of the biology underlying their role is still emerging. The goal of this review is to present an overview of the current state of knowledge of miRNAs involved in the development of NAFLD across a range of in vitro and in vivo models, including miRNAs that contribute to pathological mechanisms related to fatty liver in humans. Much less is known about the specific targets of miRNAs in cells, nor the molecular mechanisms involved in the development and progression NAFLD and related outcomes. More recently, the identification and validation of miRNA signatures in serum may facilitate the development of improved methods for diagnosis and clinical monitoring of disease progression. Core tip: Available data on miRNAs in nonalcoholic fatty liver disease (NAFLD) are largely derived from various cell culture and animal models. Reflecting an emerging field, little cross-model concordance is present and few human data are available for comparison with cell culture and animal model results. Although the generation of human data may be limited by the availability of tissue samples, recent reports of circulating miRNAs from NAFLD patients hold promise for significant progress for diagnosis and clinical MINIREVIEWSSubmit a

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Section: In Vivo Studiesmentioning

confidence: 99%

Micro RNAs in the development of non-alcoholic fatty liver disease

Gerhard

DiStefano

2014

WJH

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“…A decrease in miR-122 led to hepatic insulin resistance, while licorice flavonoids had been shown to reduce obesity-induced insulin resistance (Yang et al 2012). Joven et al (2012) showed that plantderived polyphenols could regulate the expression of miRNA paralogs, miR-103/-107 and miR-122, and prevent diet-induced fatty liver disease in hyperlipidemic mice. Moreover, Parra et al (2010) showed that adipose miRNAs (miR-103/-107, miR-122, and miR-123) were sensitive to dietary conjugated linoleic acid treatment in mice.…”

Section: Pkb (Akt) Signaling (Insulin Sensitivity)mentioning

confidence: 99%

Application of microRNAs in diabetes mellitus

Chen¹,

Lan²,

Roukos³

et al. 2014

Journal of Endocrinology

109

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MicroRNAs (miRNAs) are small molecules negatively regulating gene expression by diminishing their target mRNAs. Emerging studies have shown that miRNAs play diverse roles in diabetes mellitus. Type 1 diabetes (T1D) and T2D are two major types of diabetes. T1D is characterized by a reduction in insulin release from the pancreatic b-cells, while T2D is caused by islet b-cell dysfunction in response to insulin resistance. This review describes the miRNAs that control insulin release and production by regulating cellular membrane electrical excitability (ATP:ADP ratio), insulin granule exocytosis, insulin synthesis in b-cells, and b-cell fate and islet mass formation. This review also examines miRNAs involved the insulin resistance of liver, fat, and skeletal muscle, which change insulin sensitivity pathways (insulin receptors, glucose transporter type 4, and protein kinase B pathways). This review discusses the potential application of miRNAs in diabetes, including the use of gene therapy and therapeutic compounds to recover miRNA function in diabetes, as well as the role of miRNAs as potential biomarkers for T1D and T2D.

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“…Another example of how miR may function to allow an organism to adapt to environmental changes is through diet-induced miR activity. We were unable to find any published studies describing the effect of dietary factors on miR activity and dyslipidemia performed in humans, but several in vitro and animal model studies of other conditions indicate that this relationship is plausible (23,25,29,31,47,48,53,60). Increasing interest in the implications of miRs in the area of gene-environment interactions is evidenced by the recent creation of the miREnvironment Database, which cross-references miR species with environmental risk factors and phenotypes (59).…”

Section: Gene-environment Interactionsmentioning

confidence: 90%