Plant fructokinases: a sweet family get-together

Pego, Jónatas V.; Smeekens, Sjef

doi:10.1016/s1360-1385(00)01783-0

Cited by 130 publications

(104 citation statements)

References 60 publications

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“…Therefore, sensing of glucose and fructose by separate systems seems important to monitor these sugars at the cellular level. Like glucose, fructose probably is an evolutionarily conserved signaling molecule in plants (9), fungi (28), and mammals (29). However, in plants convincing evidence for the signaling function of fructose is lacking.…”

Section: Discussionmentioning

confidence: 99%

“…Sucrose-specific signaling also was demonstrated because the effect of sucrose cannot be mimicked by glucose and/or fructose (7), but so far no information on sucrosesensing systems is available. A signaling function for fructose has been proposed (8,9), but no convincing experimental evidence on such fructose-specific signaling is available.…”

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confidence: 99%

“…Most likely, fructose is phosphorylated mainly by fructokinases (FRKs), and a member of that gene family is present in Arabidopsis. The putative regulatory role of FRK in fructose signaling was investigated first in tomato (9,19). Inhibition of the tomato fructokinase 2 (LeFRK2) interferes with development of phloem and xylem by impairing callose deposition, thus reducing transport of sugars and water (20).…”

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confidence: 99%

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Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Wind

Shi

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

115

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In living organisms sugars not only provide energy and carbon skeletons but also act as evolutionarily conserved signaling molecules. The three major soluble sugars in plants are sucrose, glucose, and fructose. Information on plant glucose and sucrose signaling is available, but to date no fructose-specific signaling pathway has been reported. In this study, sugar repression of seedling development was used to study fructose sensitivity in the Landsberg erecta (Ler)/Cape Verde Islands (Cvi) recombinant inbred line population, and eight fructose-sensing quantitative trait loci (QTLs) (FSQ1-8) were mapped. Among them, FSQ6 was confirmed to be a fructose-specific QTL by analyzing near-isogenic lines in which Cvi genomic fragments were introgressed in the Ler background. These results indicate the existence of a fructose-specific signaling pathway in Arabidopsis. Further analysis demonstrated that the FSQ6-associated fructose-signaling pathway functions independently of the hexokinase1 (HXK1) glucose sensor. Remarkably, fructosespecific FSQ6 downstream signaling interacts with abscisic acid (ABA)-and ethylene-signaling pathways, similar to HXK1-dependent glucose signaling. The Cvi allele of FSQ6 acts as a suppressor of fructose signaling. The FSQ6 gene was identified using mapbased cloning approach, and FSQ6 was shown to encode the transcription factor gene Arabidopsis NAC (petunia No apical meristem and Arabidopsis transcription activation factor 1, 2 and Cup-shaped cotyledon 2) domain containing protein 89 (ANAC089). The Cvi allele of FSQ6/ANAC089 is a gain-of-function allele caused by a premature stop in the third exon of the gene. The truncated Cvi FSQ6/ ANAC089 protein lacks a membrane association domain that is present in ANAC089 proteins from other Arabidopsis accessions. As a result, Cvi FSQ6/ANAC089 is constitutively active as a transcription factor in the nucleus. I n plants, sugars provide the energy and carbon skeletons needed for growth and in addition act as crucial signaling molecules that affect growth, development, and response to the (a)biotic environment (1-3). Plant cells harbor sugar-sensing and -signaling systems that regulate the expression of thousands of genes and control the metabolic processes needed for growth (2-4). These sugar-response systems are known to interact with other signaling pathways, such as those for light, phytohormones, stress, and nutrients (1).The neutral sugars sucrose, glucose, and fructose are central to metabolism in plants and in other organisms as well. So far, detailed information is available only on glucose sensing, and it has been shown that the hexokinase 1 (HXK1) enzyme acts as a glucose sensor (5, 6). Sucrose-specific signaling also was demonstrated because the effect of sucrose cannot be mimicked by glucose and/or fructose (7), but so far no information on sucrosesensing systems is available. A signaling function for fructose has been proposed (8, 9), but no convincing experimental evidence on such fructose-specific signaling is available.In Arabidopsis ea...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Wind

Shi

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

115

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“…Fructokinase is an important enzyme that is involved in energy production and also in storing sugars (Pego and Smeekens, 2000). Sink organs receive sucrose transported from source organs, and then sucrose is used for their development or is converted into starch (Schaffer and Petreikov, 1997).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility to Coolness at the Young Microspore Stage under High Nitrogen Supply in Rice (Oryza SativaL.). Proteome Analysis of Mature Anthers

Hayashi

Yamaguchi

Nakayama

et al. 2006

Plant Production Science

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“…3, D and F), which could imply that invertases do not occupy a central position in the Suc to cell wall pathway. However, the cytosolic pools of Glc and Fru relevant for cell wall biosynthesis can be expected to quickly convert into hexose-Ps because of the micromolar-range substrate affinities of plant hexo-and fructokinases (Renz and Stitt, 1993;Pego and Smeekens, 2000). The labeling pattern of the developing wood hexose-Ps and UDP-Glc followed the pattern of Suc (Fig.…”

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¹³C Tracking after ¹³CO₂ Supply Revealed Diurnal Patterns of Wood Formation in Aspen

et al. 2015

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Wood of trees is formed from carbon assimilated in the photosynthetic tissues. Determining the temporal dynamics of carbon assimilation, subsequent transport into developing wood, and incorporation to cell walls would further our understanding of wood formation in particular and tree growth in general. To investigate these questions, we designed a 13 CO 2 labeling system to study carbon transport and incorporation to developing wood of hybrid aspen (Populus tremula 3 tremuloides). Tracking of 13 C incorporation to wood over a time course using nuclear magnetic resonance spectroscopy revealed diurnal patterns in wood cell wall biosynthesis. The dark period had a differential effect on 13 C incorporation to lignin and cell wall carbohydrates. No 13 C was incorporated into aromatic amino acids of cell wall proteins in the dark, suggesting that cell wall protein biosynthesis ceased during the night. The results show previously unrecognized temporal patterns in wood cell wall biosynthesis, suggest diurnal cycle as a possible cue in the regulation of carbon incorporation to wood, and establish a unique 13 C labeling method for the analysis of wood formation and secondary growth in trees.

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Plant fructokinases: a sweet family get-together

Cited by 130 publications

References 60 publications

Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Susceptibility to Coolness at the Young Microspore Stage under High Nitrogen Supply in Rice (Oryza SativaL.). Proteome Analysis of Mature Anthers

¹³C Tracking after ¹³CO₂ Supply Revealed Diurnal Patterns of Wood Formation in Aspen

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Plant fructokinases: a sweet family get-together

Cited by 130 publications

References 60 publications

Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Susceptibility to Coolness at the Young Microspore Stage under High Nitrogen Supply in Rice (Oryza SativaL.). Proteome Analysis of Mature Anthers

13C Tracking after 13CO2 Supply Revealed Diurnal Patterns of Wood Formation in Aspen

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¹³C Tracking after ¹³CO₂ Supply Revealed Diurnal Patterns of Wood Formation in Aspen