Plant immune receptor pathways as a united front against pathogens

Yuan, Minhang; Cai, Boying; Xin, Xiu-Fang

doi:10.1371/journal.ppat.1011106

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…Pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) are the two layers of immune systems that play critical roles in defense responses (Dangl, et al 2013 ; Ngou, et al 2022 ). PAMPs are perceived and recognized by pattern recognition receptors (PRRs) localized at the cell surface which initiate PTI, the first layer of plant immune system (Bernoux, et al 2022 ; Yuan, et al 2023 ). To survive and colonize host plants, pathogens often secrete virulence effectors into host cells to suppress PTI.…”

Section: Introductionmentioning

confidence: 99%

Plant disease resistance outputs regulated by AP2/ERF transcription factor family

Ma,

Sun,

et al. 2024

Stress Biology

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Plants have evolved a complex and elaborate signaling network to respond appropriately to the pathogen invasion by regulating expression of defensive genes through certain transcription factors. The APETALA2/ethylene response factor (AP2/ERF) family members have been determined as key regulators in growth, development, and stress responses in plants. Moreover, a growing body of evidence has demonstrated the critical roles of AP2/ERFs in plant disease resistance. In this review, we describe recent advances for the function of AP2/ERFs in defense responses against microbial pathogens. We summarize that AP2/ERFs are involved in plant disease resistance by acting downstream of mitogen activated protein kinase (MAPK) cascades, and regulating expression of genes associated with hormonal signaling pathways, biosynthesis of secondary metabolites, and formation of physical barriers in an MAPK-dependent or -independent manner. The present review provides a multidimensional perspective on the functions of AP2/ERFs in plant disease resistance, which will facilitate the understanding and future investigation on the roles of AP2/ERFs in plant immunity.

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Section: Introductionmentioning

confidence: 99%

Plant disease resistance outputs regulated by AP2/ERF transcription factor family

Ma,

Sun,

et al. 2024

Stress Biology

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“…Plants contain innate immune receptors that can recognize all pathogen classes. Pathogen recognition can occur extracellularly via cell-surface localized pattern recognition receptors (PRRs) leading to pattern-triggered immunity (PTI), or intracellularly through recognition of pathogen encoded effectors by nucleotide-binding domain leucine-rich repeat receptors (NLRs) leading to effector-triggered immunity (ETI) (Yuan et al, 2023). NLRs and PRRs mutually potentiate each other and their activation leads to convergent responses (Yuan et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

“…Pathogen recognition can occur extracellularly via cell-surface localized pattern recognition receptors (PRRs) leading to pattern-triggered immunity (PTI), or intracellularly through recognition of pathogen encoded effectors by nucleotide-binding domain leucine-rich repeat receptors (NLRs) leading to effector-triggered immunity (ETI) (Yuan et al, 2023). NLRs and PRRs mutually potentiate each other and their activation leads to convergent responses (Yuan et al, 2023). Common plant immune responses include ion influxes, rapid production of reactive oxygen species (ROS), transcriptional reprogramming, deposition of structural barriers, and stomatal closure, all of which culminate in resistance (Yuan et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Gene editing of the E3 ligasePIRE1fine-tunes ROS production for enhanced bacterial disease resistance in tomato

Castro,

Baik,

Tran

et al. 2024

Preprint

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Reactive oxygen species (ROS) accumulation is required for effective plant defense. Accumulation of the Arabidopsis NADPH oxidase RBOHD is regulated by phosphorylation of a conserved C-terminal residue (T912) leading to ubiquitination by the RING E3 ligase PIRE. ArabidopsisPIREknockouts exhibit enhanced ROS production and resistance to the foliar pathogenPseudomonas syringae. Here, we identified 170PIREhomologs, which emerged in Tracheophytes and expanded in Angiosperms. We investigated the role ofSolanum lycopersicum(tomato) PIRE homologs in regulating ROS production, RBOH stability, and disease resistance. Mutational analyses of residues corresponding to T912 in the tomato RBOHD ortholog, SlRBOHB, affected protein accumulation and ROS production in aPIRE-dependent manner. Using CRISPR-cas9, we generated mutants in twoS. lycopersicum PIREhomologs (SlPIRE).SlPIRE1edited lines (Slpire1) in the tomato cultivar M82 displayed enhanced ROS production upon treatment with flg22, an immunogenic epitope of flagellin. Furthermore, Slpire1exhibited decreased disease symptoms and bacterial accumulation when inoculated with foliar bacterial pathogensPseudomonas syringaeandXanthomonas campestris. However,Slpire1exhibited similar levels of colonization as wild type upon inoculation with diverse soilborne pathogens. These results indicate that phosphorylation and ubiquitination crosstalk regulate RBOHs in multiple plant species, andPIREis a promising target for foliar disease control. This study also highlights the pathogen-specific role ofPIRE, indicating its potential for targeted manipulation to enhance foliar disease resistance without affecting root-associated interactions, positioningPIREas a promising target for improving overall plant health.

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“…NLRs function as “sensors” that recognize effectors, or as “helpers” that mediate signaling downstream of sensor NLRs (Jubic et al ., 2019). Recent studies demonstrated that PTI and ETI work together to mutually potentiate the immune response (Yuan et al ., 2021b; Yuan et al ., 2023). NLR-mediated signaling is dependent on multiple PTI-associated components such as BAK1, SOBIR1, or BIK1 in a PTI-independent manner, while TNL genes that are up-regulated during early PTI boost immune responses (Ngou et al ., 2021; Tian et al ., 2021; Yuan et al ., 2021a).…”

Section: Introductionmentioning

confidence: 99%

The receptor-like kinase BIR1 inhibits elicitor-induced plasmodesmata callose deposition and PTI gene expression and requires EDS1 and SOBIR1 to cause dose-dependent cell-death in Arabidopsis

Guzmán-Benito

Robinson

Hua

et al. 2023

Preprint

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The receptor-like kinase BIR1 functions as a negative regulator of cell death and defense in Arabidopsis. Previous studies showed that BIR1 expression is up-regulated during infections with microbes and viruses. However, the biological consequences of BIR1 induction remain unknown. Here, we use a DEX-inducible expression system in Arabidopsis to investigate the outputs associated with physiological and non-physiological levels of BIR1 expression. We show that BIR1 induction at physiological levels significantly interferes with gene expression and plasmodesmata callose deposition triggered by canonical PTI elicitors. We found that plants that accumulated non-physiological doses of BIR1 displayed morphological defects that concur with transcriptomic changes in multiple plant defense genes. We provide experimental evidence that EDS1 and SOBIR1 are required for the ETI-type cell death phenotypes associated to non-physiological levels of BIR1. Here we propose that BIR1 induction may represent a pathogen-triggered mechanism to modulate plant defenses during infection. Our model posits that when BIR1 regulation is lost, BIR1 integrity is sensed by one or several guarding resistance (R) proteins to initiate an ETI-like response, in which SOBIR1 cooperates with EDS1 to transduce signals downstream of R proteins.

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Plant immune receptor pathways as a united front against pathogens

Cited by 9 publications

References 43 publications

Plant disease resistance outputs regulated by AP2/ERF transcription factor family

Plant disease resistance outputs regulated by AP2/ERF transcription factor family

Gene editing of the E3 ligasePIRE1fine-tunes ROS production for enhanced bacterial disease resistance in tomato

The receptor-like kinase BIR1 inhibits elicitor-induced plasmodesmata callose deposition and PTI gene expression and requires EDS1 and SOBIR1 to cause dose-dependent cell-death in Arabidopsis

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