Plant Natural Products for Human Health

Tao, Chun; Zhang, Hongjie

doi:10.3390/ijms20040830

Cited by 71 publications

(47 citation statements)

References 26 publications

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“…Medicinal plants have proven their pharmacological activities historically and nowadays still represent a valuable source of new drugs reaching the market (Atanasov et al, 2015;Che and Zhang, 2019). Due to their advantages for human health, researchers have long shown interest in phenolic and flavonoids agents in (ABTS radical cation scavenging activity in %) A. sieberi 6 ± 0.9 12.3 ± 2.9 21.9 ± 1.9 54.1 ± 2.4 71.3 ± 2.3 A. judaica 5.6 ± 0.6 9.3 ± 1.1 18.6 ± 1.1 43.9 ± 1.9 63.3 ± 2.1 Ascorbic acid 80.7 ± 2.4 81.2 ± 2.1 84.2 ± 1.9 87.2 ± 2.4 88.7 ± 2.1…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, plants were and still represent a rich source of new therapeutic agents for the treatment of several primary health care ailments. In addition, there are several reports available where natural products have shown their promising potential to cure complex diseases (Newman and Cragg, 2016;Mushtaq et al, 2018;Thomford et al, 2018;Che and Zhang, 2019). In the area of cancer treatment, which now represents the most common and second most lethal disease in the world (Siegel et al, 2020), medicinal plants contribute to anticancer drugs that inhibit tumor progression without many side effects (Dall'Acqua, 2014;Khazir et al, 2014;Iqbal et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic, antimicrobial and antioxidant activities and phytochemical analysis of Artemisia judaica and A. sieberi in Saudi Arabia

Nasr¹,

Noman²,

Mothana³

et al. 2020

Afr. J. Pharm. Pharmacol.

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Cancer and microbial infectious diseases are considered a global threat. Plants have been investigated across the world to exploit their potential anticancer and antimicrobial effective agents. In this study, two medicinal plant species native to Saudi Arabia, namely; Artemisia judaica and Artemisia sieberi were screened to assess their antioxidant, anticancer and antimicrobial potential activities as well as phytochemical compositions. The collected aerial parts were extracted by maceration with methanol. Cytotoxic and antimicrobial activities were investigated using the MTT and MIC assays, respectively. Free radical scavenging and antioxidant potential were assessed respectively by 2, 2-diphenyl-1picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. The total flavonoid and phenolic contents of the crude methanolic extract were quantified using standard methods. Artemisia judaica displayed a strong cytotoxicity compared to A. sieberi while both species showed approximately similar bacterial and fungal growth inhibition. In contrast, A. sieberi displayed the highest phenol and flavonoid contents between the two species which was consistent with the higher antioxidant activity found in A. sieberi. It is concluded that both Artemisia species could be a promising source of antioxidant, anticancer and antimicrobial agents.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxic, antimicrobial and antioxidant activities and phytochemical analysis of Artemisia judaica and A. sieberi in Saudi Arabia

Nasr¹,

Noman²,

Mothana³

et al. 2020

Afr. J. Pharm. Pharmacol.

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“…Several anti-obesity medicinal therapies are used for weight loss but have adverse effects, such as headache, nausea, dizziness and fatigue [12,13]. Natural products have emerged as an alternative modern therapy for diseases such as cancer, hypertrophy, diabetes mellitus, burning sensation and cardiovascular disease because they are culturally appropriate sources of primary health care with few side effects [14][15][16]. Studies report that combined natural products promote advantages of synergistic effects on prevention of side effects compared to single treatments [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Antiadipogenic Effects of Mixtures of Cornus officinalis and Ribes fasciculatum Extracts on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Mice

Park

Lee

Jeong³

et al. 2020

Molecules

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Medicinal plants have been used worldwide as primary alternative healthcare supplements. Cornus officinalis (CO) and Ribes fasciculatum (RF) are traditional medicinal plants applied in East Asia to treat human diseases such as hepatitis, osteoporosis, oxidative stress and allergy. The aim of this study was to examine the anti-obesity effect of CO and RF on preadipocyte 3T3-L1 cells in vitro and high-fat diet (HFD)-induced obesity mice in vivo. Combination treatment of CO and RF in differentiated 3T3-L1 cells inhibited adipocyte differentiation through downregulation of adipogenesis-associated genes such as CCAAT/enhancer-binding protein alpha (Cebpa), fatty acid binding protein 4 (Fabp4), peroxisome proliferator-activated receptor gamma (Pparg) and sterol regulatory element binding protein (Srebp1). In vivo animal models showed that a mixture of CO and RF inhibited HFD-induced weight gain, resulting in decreased abdominal visceral fat tissues and fatty hepatocyte deposition. In addition, CO+RF treatment decreased HFD-induced adipogenesis-associated genes in abdominal white fat tissue. These results suggest that administration of a CO and RF mixture prevented adipocyte differentiation and lipid accumulation in preadipocyte cells and HFD-induced body weight in obesity mice. Therefore, combined therapy of CO and RF may be a protective therapeutic agent against obesity.

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“…Herbs and plant extracts are considered as potential candidates for drug development and serve as alternative therapies for cancer treatment with minimal side effects ( 6 ). In recent years, plant-based drugs have attracted great interest due to their anticancer properties, and have gradually become a research focus ( 7 ). Previous studies indicate that the majority of medicinal and aromatic herbs contain valuable compounds with unique properties ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis

et al. 2020

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Linalool is an unsaturated terpene that can be found in several plants and exhibits various biological activities. The aim of the present study was to investigate the anticancer activity of linalool using the human prostate cancer 22Rv1 cell line. Flow cytometry was employed to study the effects of linalool on the induction of apoptosis, cell cycle progression, loss of mitochondrial membrane potential and cytochrome c release, whereas the effects of linalool on apoptosis-associated proteins were investigated by western blot analysis. An efficacy study was conducted using 22Rv1 tumor-bearing mice. The expression of the cell proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) in xenograft tumors was evaluated by immunohistochemistry. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was used to study the induction of apoptosis in an in vivo model. Linalool exerted an inhibitory effect on 22Rv1 cell proliferation and induced apoptosis in both in vitro and in vivo models. Western blot analysis indicated that both the mitochondria-mediated intrinsic and death-receptor-mediated extrinsic pathways were involved in the induction of apoptosis. Furthermore, linalool significantly reduced the expression of Ki-67 and PCNA in the 22Rv1 xenograft model. The findings of the present study provide evidence supporting the anti-proliferative effects of linalool on 22Rv1 human prostate cancer cells, and suggest that linalool may be an effective agent for prostate cancer treatment.

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Plant Natural Products for Human Health

Cited by 71 publications

References 26 publications

Cytotoxic, antimicrobial and antioxidant activities and phytochemical analysis of Artemisia judaica and A. sieberi in Saudi Arabia

Cytotoxic, antimicrobial and antioxidant activities and phytochemical analysis of Artemisia judaica and A. sieberi in Saudi Arabia

Antiadipogenic Effects of Mixtures of Cornus officinalis and Ribes fasciculatum Extracts on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Mice

Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis

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