Plant Neoflavonoids: Chemical Structures and Biological Functions

Kumar, Pradeep; Ahamad, Tanveer; Mishra, Devendra; Khan, Mohammad Faheem

doi:10.1007/978-981-15-2361-8_3

Cited by 6 publications

(3 citation statements)

References 71 publications

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“…The most abundantly found neo-flavone is Dalbergin isolated from various plants of the genus Dalbergia. NFs exhibit several therapeutic properties which include anti-allergic, anti-inflammatory, anti-osteoporotic, antimicrobial and anti-oxidant ( 61 ).…”

Section: Classification Of Flavonoidsmentioning

confidence: 99%

Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling

et al. 2021

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Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea plants, and stems and many more natural commodities. They have a multitude of applications through their anti-inflammatory, anti-oxidative, anti-carcinogenic properties, along with the ability to assist in the stimulation of bone formation. Bone, a rigid connective body tissue made up of cells embedded in a mineralised matrix is maintained by an assemblage of pathways assisting osteoblastogenesis and osteoclastogenesis. These have a significant impact on a plethora of bone diseases. The homeostasis between osteoblast and osteoclast formation decides the integrity and structure of the bone. The flavonoids discussed here are quercetin, kaempferol, icariin, myricetin, naringin, daidzein, luteolin, genistein, hesperidin, apigenin and several other flavonoids. The effects these flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa β (NF-kβ), Wnt/β-catenin and bone morphogenetic protein 2/SMAD (BMP2/SMAD) signalling pathways, and apoptotic pathways lead to impacts on bone remodelling. In addition, these polyphenols regulate angiogenesis, decrease the levels of inflammatory cytokines and play a crucial role in scavenging reactive oxygen species (ROS). Considering these important effects of flavonoids, they may be regarded as a promising agent in treating bone-related ailments in the future.

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Section: Classification Of Flavonoidsmentioning

confidence: 99%

Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling

et al. 2021

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“…Neoflavonoids, which were first isolated from Calophyllum inophyllum seeds in the 1950s, are found infrequently in food and edible plants but are widely distributed in plant families belonging to the genus of Dalbergia. 59 In a narrow sense, flavonoids normally possess a 2phenylchromen-4-one backbone; further modifications on this backbone involve, but are not limited to, the degree of carbon oxidation and saturation of the C ring. 4 Chemicals from this category consist of flavones, which maintain a double bond between positions 2 and 3.…”

Section: Flavonoids and Their Derivativesmentioning

confidence: 99%

“…Another subclass, in which the B ring is linked at position 4 (4-phenylchroman backbone), is called neoflavonoids. Neoflavonoids, which were first isolated from Calophyllum inophyllum seeds in the 1950s, are found infrequently in food and edible plants but are widely distributed in plant families belonging to the genus of Dalbergia …”

Section: Flavonoids and Their Derivativesmentioning

confidence: 99%

Potential of Producing Flavonoids Using Cyanobacteria As a Sustainable Chassis

Jin

Wang

Zhao

et al. 2021

J. Agric. Food Chem.

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Numerous plant secondary metabolites have remarkable impacts on both food supplements and pharmaceuticals for human health improvement. However, higher plants can only generate small amounts of these chemicals with specific temporal and spatial arrangements, which are unable to satisfy the expanding market demands. Cyanobacteria can directly utilize CO 2 , light energy, and inorganic nutrients to synthesize versatile plant-specific photosynthetic intermediates and organic compounds in largescale photobioreactors with outstanding economic merit. Thus, they have been rapidly developed as a "green" chassis for the synthesis of bioproducts. Flavonoids, chemical compounds based on aromatic amino acids, are considered to be indispensable components in a variety of nutraceutical, pharmaceutical, and cosmetic applications. In contrast to heterotrophic metabolic engineering pioneers, such as yeast and Escherichia coli, information about the biosynthesis flavonoids and their derivatives is less comprehensive than that of their photosynthetic counterparts. Here, we review both benefits and challenges to promote cyanobacterial cell factories for flavonoid biosynthesis. With increasing concerns about global environmental issues and food security, we are confident that energy self-supporting cyanobacteria will attract increasing attention for the generation of different kinds of bioproducts. We hope that the work presented here will serve as an index and encourage more scientists to join in the relevant research area.

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