“…The accumulation of some lipids might be an immediate defense to alleviate heavy metal stress and maintain normal growth rates (Yu et al, 2012;Leong and Chang, 2020). In the present work, the significant upregulated five lipids (16-Methylheptadecanoic acid, Stearic Acid, 3-Hydroxy-palmitic acid methyl ester, D-Sphingosine, and Hydroxyicosanoic Acid) of G. bailiniae in the Cd treatment groups might contribute to enhanced antioxidant ability, membrane defense, and cellular programmed regulation to alleviate the Cd stress (Hernandez and Cooke, 1997;Howlett and Avery, 1997;Devi and Prasad, 1999;Khan et al, 2013;Narayanan and Park, 2013;Michaelson et al, 2016;Dwivedi et al, 2017). However, such defense types were insufficient, resulting in another five lipids (15-Oxo-5Z,8Z,11Z,13Eeicosatetraenoic acid, 12-Oxo-5,8,10,14-eicosatetraenoic acid, 2-Linoleoylglycerol, LysoPE 18:1, and LysoPE 20:5) being significantly down-regulated.…”