Plant peptides in plant defense responses

Hu, Zhangjian; Zhang, H.; Shi, Kai

doi:10.1080/15592324.2018.1475175

Cited by 19 publications

(16 citation statements)

References 53 publications

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“…Plants produce a variety of defensive antimicrobial peptides, many of which are cysteine-rich peptides (CRPs), such as cyclotides, defensins, knottins, snakins, and thionins ( 74 , 75 , 76 , 77 , 80 , 81 ). Here, we confine the discussion of the biomedical applications of compounds with a molecular mass ≤7 kDa and thereby exclude small defense proteins such as puroindolines and lipid transfer proteins.…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

“…Many PAs such as alkaloids, phenylpropanoids, and some sulfur-containing compounds are derived from amino acid precursors ( 73 ). In addition to these small molecule PAs, plants produce several classes of antimicrobial peptides as part of their defense response ( 74 , 75 , 76 , 77 ). PAs and defense peptides typically target specific biological processes and are used by plants to fight microbial infection, to deter feeding by herbivores, and during competition against other plants ( 78 , 79 ).…”

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confidence: 99%

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Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

Parthasarathy

Borrego

Savka

et al. 2021

Journal of Biological Chemistry

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For millennia, humanity has relied on plants for its medicines, and modern pharmacology continues to reexamine and mine plant metabolites for novel compounds and to guide improvements in biological activity, bioavailability, and chemical stability. The critical problem of antibiotic resistance and increasing exposure to viral and parasitic diseases has spurred renewed interest into drug treatments for infectious diseases. In this context, an urgent revival of natural product discovery is globally underway with special attention directed toward the numerous and chemically diverse plant defensive compounds such as phytoalexins and phytoanticipins that combat herbivores, microbial pathogens, or competing plants. Moreover, advancements in “ omics ,” chemistry, and heterologous expression systems have facilitated the purification and characterization of plant metabolites and the identification of possible therapeutic targets. In this review, we describe several important amino acid–derived classes of plant defensive compounds, including antimicrobial peptides ( e.g. , defensins, thionins, and knottins), alkaloids, nonproteogenic amino acids, and phenylpropanoids as potential drug leads, examining their mechanisms of action, therapeutic targets, and structure–function relationships. Given their potent antibacterial, antifungal, antiparasitic, and antiviral properties, which can be superior to existing drugs, phytoalexins and phytoanticipins are an excellent resource to facilitate the rational design and development of antimicrobial drugs.

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Section: Antimicrobial Peptidesmentioning

confidence: 99%

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confidence: 99%

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

Parthasarathy

Borrego

Savka

et al. 2021

Journal of Biological Chemistry

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“…Thus, short peptide chains were also present in the formed hydrolysate. Peptides are responsible for transmitting signals between the cells in the plant during growth and stress conditions [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Alginate Seed Coating as an Innovative Method for Delivering Nutrients at the Early Stages of Plant Growth

et al. 2021

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Seed coating containing fertilizer nutrients and plant growth biostimulants is an innovative technique for precision agriculture. Nutrient delivery can also be conducted through multilayer seed coating. For this purpose, sodium alginate with NPK, which was selected in a preliminary selection study, crosslinked with divalent ions (Cu(II), Mn(II), Zn(II)) as a source of fertilizer micronutrients, was used to produce seed coating. The seeds were additionally coated with a solution containing amino acids derived from high-protein material. Amino acids can be obtained by alkaline hydrolysis of mealworm larvae (Gly 71.2 ± 0.6 mM, Glu 55.8 ± 1.3 mM, Pro 48.8 ± 1.5 mM, Ser 31.4 ± 1.5 mM). The formulations were applied in different doses per 100 g of seeds: 35 mL, 70 mL, 105 mL, and 140 mL. SEM-EDX surface analysis showed that 70 mL of formulation/100 g of seeds formed a continuity of coatings but did not result in a uniform distribution of components on the surface. Extraction tests proved simultaneous low leaching of nutrients into water (max. 10%), showing a slow release pattern. There occurred high bioavailability of fertilizer nutrients (even up to 100%). Pot tests on cucumbers (Cornichon de Paris) confirmed the new method’s effectiveness, yielding a 50% higher fresh sprout weight and four times greater root length than uncoated seeds. Seed coating with hydrogel has a high potential for commercial application, stimulating the early growth of plants and thus leading to higher crop yields.

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“…Plant peptides secreted as signal transmitters for cell-to-cell communication are indispensable for plant growth and development, and defense processes in plant-microbe interactions (Hu et al, 2018). To develop a recognition-based disease resistance strategy for broad-spectrum, durable disease resistance in crops, we screened for endogenous peptides that activate immune responses against pathogens in N. tabacum by employing an A. tumefaciens-mediated transient expression method.…”

Section: Discussionmentioning

confidence: 99%

The novel peptide NbPPI1 identified from Nicotiana benthamiana triggers immune responses and enhances resistance against Phytophthora pathogens

Wen

Sun

Kong

et al. 2021

JIPB

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In plants, recognition of small secreted peptides, such as damage/danger-associated molecular patterns (DAMPs), regulates diverse processes, including stress and immune responses. Here, we identified an SGPS (Ser-Gly-Pro-Ser) motif-containing peptide, Nicotiana tabacum NtPROPPI, and its two homologs in Nicotiana benthamiana, NbPROPPI1 and NbPROPPI2. Phytophthora parasitica infection and salicylic acid (SA) treatment induced NbPROPPI1/2 expression. Moreover, SignalP predicted that the 89-amino acid NtPROPPI includes a 24-amino acid N-terminal signal peptide and NbPROPPI1/2-GFP fusion proteins were mainly localized to the periplasm. Transient expression of NbPROPPI1/2 inhibited P. parasitica colonization, and NbPROPPI1/2 knockdown rendered plants more susceptible to P. parasitica. An eight-amino-acid segment in the NbPROPPI1 C-terminus was essential for its immune function and a synthetic 20-residue peptide, NbPPI1, derived from the C-terminus of NbPROPPI1 provoked significant immune responses in N. benthamiana. These responses led to enhanced accumulation of reactive oxygen species, activation of mitogen-activated protein kinases, and up-regulation of the defense genes Flg22-induced receptor-like kinase (FRK) and WRKY DNA-binding protein 33 (WRKY33). The NbPPI1-induced defense responses require Brassinosteroid insensitive 1-associated receptor kinase 1 (BAK1). These results suggest that NbPPI1 functions as a DAMP in N. benthamiana; this novel DAMP provides a potentially useful target for improving plant resistance to Pytophthora pathogens.

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Plant peptides in plant defense responses

Cited by 19 publications

References 53 publications

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

Hydrogel Alginate Seed Coating as an Innovative Method for Delivering Nutrients at the Early Stages of Plant Growth

The novel peptide NbPPI1 identified from Nicotiana benthamiana triggers immune responses and enhances resistance against Phytophthora pathogens

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