Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders

Farjadmand, Fatemeh; Karimpour-Razkenari, Elahe; Nabavi, Seyed Mohammad; Ardekani, Mohammad Reza Shams; Saeedi, Mina

doi:10.2174/1389557520666201109121246

Cited by 11 publications

(4 citation statements)

References 91 publications

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“…The ability of some flavonoids to suppress the expression of COX-2 may underlie the mechanisms of the protective action of these substances against the action of UV radiation, as was shown for baicalein and wogonin, hesperetin, magniferin and tangeritin (Fischer et al, 2018;Farjadmand et al, 2021). It is possible that this regulation is carried out through the mitogen-activated protein kinase (MAPK) regulatory pathway, as was shown for luteolin (Aziz et al, 2018).…”

Section: Mechanisms Of Protective Action Against Ultraviolet Radiationmentioning

confidence: 94%

Modern aspects of the use of natural polyphenols in tumor prevention and therapy

Суфианова

Gareev

Beylerli

et al. 2022

Front. Cell Dev. Biol.

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Polyphenols are secondary plant metabolites or organic compounds synthesized by them. In other words, these are molecules that are found in plants. Due to the wide variety of polyphenols and the plants in which they are found, these compounds are divided according to the source of origin, the function of the polyphenols, and their chemical structure; where the main ones are flavonoids. All the beneficial properties of polyphenols have not yet been studied, since this group of substances is very extensive and diverse. However, most polyphenols are known to be powerful antioxidants and have anti-inflammatory effects. Polyphenols help fight cell damage caused by free radicals and immune system components. In particular, polyphenols are credited with a preventive effect that helps protect the body from certain forms of cancer. The onset and progression of tumors may be related directly to oxidative stress, or inflammation. These processes can increase the amount of DNA damage and lead to loss of control over cell division. A number of studies have shown that oxidative stress uncontrolled by antioxidants or an uncontrolled and prolonged inflammatory process increases the risk of developing sarcoma, melanoma, and breast, lung, liver, and prostate cancer. Therefore, a more in-depth study of the effect of polyphenolic compounds on certain signaling pathways that determine the complex cascade of oncogenesis is a promising direction in the search for new methods for the prevention and treatment of tumors.

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Section: Mechanisms Of Protective Action Against Ultraviolet Radiationmentioning

confidence: 94%

Modern aspects of the use of natural polyphenols in tumor prevention and therapy

Суфианова

Gareev

Beylerli

et al. 2022

Front. Cell Dev. Biol.

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“…The AA treatment may include using antioxidant supplements to alleviate oxidative stress or antioxidants in combination with other therapeutic strategies to boost melanocyte oxidative capacity. Several studies ( 115 – 117 ) have demonstrated that antioxidant supplements, such as Yucca, polyunsaturated fatty acids, and carotenoids, preserve melanocytes and improve the therapeutic efficacy of phototherapy in vitiligo patients.…”

Section: Hair Follicle Melanocytesmentioning

confidence: 99%

Novel potential therapeutic targets of alopecia areata

Wan

Xie

et al. 2023

Front. Immunol.

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Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity. The immune collapse of the hair follicle, where interferon-gamma (IFN-γ) and CD8+ T cells accumulate, is a key factor in AA. However, the exact functional mechanism remains unclear. Therefore, AA treatment has poor efficacy maintenance and high relapse rate after drug withdrawal. Recent studies show that immune-related cells and molecules affect AA. These cells communicate through autocrine and paracrine signals. Various cytokines, chemokines and growth factors mediate this crosstalk. In addition, adipose-derived stem cells (ADSCs), gut microbiota, hair follicle melanocytes, non-coding RNAs and specific regulatory factors have crucial roles in intercellular communication without a clear cause, suggesting potential new targets for AA therapy. This review discusses the latest research on the possible pathogenesis and therapeutic targets of AA.

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“…Flavonoids, phenols, amino acids, VC, and other Chinese olive active ingredients can be orally absorbed when ingested but can also be absorbed through the skin, having a high utilization value in the beauty and skincare industry and products ( Nagula and Wairkar, 2019 ; Farjadmand et al, 2021 ; An et al, 2023 ). As a raw material for cosmetic products, Chinese olive can reduce skin irritation and improve and solve skin problems between deep skin care and non-etiological skin problems.…”

Section: Practical Applicationsmentioning

confidence: 99%

Chinese olive (Canarium album Rauesch.): a critical review on its nutritional value, phytochemical composition, health benefits, and practical applications

Yu,

Wang,

et al. 2023

Front. Pharmacol.

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Chinese olive is a popular fruit with a long history of cultivation and consumption. As a fruit with edible, nutritional, and even medicinal value, the Chinese olive has attracted increased interest from both nutrition researchers and health-conscious consumers. Chinese olive is a rich nutrient source, including essential and non-essential amino acids, various fatty acids, organic acids, vitamins, microelements, and high-quality dietary fibers. It is also an important natural source of phytochemicals such as phenolic acids, flavonoids, phenylpropanoids, and other bioactive compounds. The nutritional and phytochemical compounds obtained from the Chinese olive exhibit unique and potent biological activities, explaining its various benefits to human health, including anti-Helicobacter pylori, anti-influenza, anti-diabetes, anti-inflammatory, anti-tumor effects, among others. This review focuses on recent studies on Chinese olives and aims to summarize the major advances in their nutritional value, phytochemical composition, health benefits, and practical applications. It provides a reference for further research on Chinese olives and their properties and the development of novel functional products.

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Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders

Cited by 11 publications

References 91 publications

Modern aspects of the use of natural polyphenols in tumor prevention and therapy

Modern aspects of the use of natural polyphenols in tumor prevention and therapy

Novel potential therapeutic targets of alopecia areata

Chinese olive (Canarium album Rauesch.): a critical review on its nutritional value, phytochemical composition, health benefits, and practical applications

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