Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

“…Indeed, jasmonates are selectively toxic toward cancer cells (Fingrut and Flescher, 2002;Rotem et al, 2005). In the leukemic cell line, Molt-4, the cytotoxicity of methyl jasmonate (MJ) was shown to be transcription-and translation-independent (Flescher, 2005).…”

“…Plant stress hormones of the jasmonate family, small hydrophobic molecules, have been previously shown to be endowed with anticancer capabilities (Fingrut and Flescher, 2002;Ishii et al, 2004), allowing for the prolonged survival of tumor-bearing animals (Fingrut and Flescher, 2002;Heyfets and Flescher, 2007) and suppression of the metastasis of murine melanoma . Indeed, jasmonates are selectively toxic toward cancer cells (Fingrut and Flescher, 2002;Rotem et al, 2005).…”

Methyl jasmonate and its potential in cancer therapy

“…5 They further showed that after treatment with MeJa, mice bearing EL-4 lymphoma can survive for significantly longer periods of time than untreated mice. 5 Other groups also showed that MeJA triggers apoptosis by not only inducing the expression of pro-apoptotic members of the Bcl -2, Bax and Bcl -XS Keywords: anticancer agent, apoptosis, cancer, cell death, methyl jasmonate protein families, but also activating caspase-3 via mitochondria in a ROS-dependent manner in human cancer cells (Fig. 2), such as A549 human lung adenocarcinoma cells.…”

“…4 In fact, Fingrut and Flescher have reported in 2002 that MeJa can induce apoptosis in human cancer cells, including Molt-4, SK-28, LNCaP, and MCF7. 5 They also demonstrated that MeJa is in contrast to another plant hormone, salicylic acid (SA), in terms of their effect on cancer cells, as the latter arrests the cell cycle and suppresses cell proliferation in each of the cell lines mentioned above. 5 They further showed that after treatment with MeJa, mice bearing EL-4 lymphoma can survive for significantly longer periods of time than untreated mice.…”

“…5 They also demonstrated that MeJa is in contrast to another plant hormone, salicylic acid (SA), in terms of their effect on cancer cells, as the latter arrests the cell cycle and suppresses cell proliferation in each of the cell lines mentioned above. 5 They further showed that after treatment with MeJa, mice bearing EL-4 lymphoma can survive for significantly longer periods of time than untreated mice. 5 Other groups also showed that MeJA triggers apoptosis by not only inducing the expression of pro-apoptotic members of the Bcl -2, Bax and Bcl -XS Keywords: anticancer agent, apoptosis, cancer, cell death, methyl jasmonate protein families, but also activating caspase-3 via mitochondria in a ROS-dependent manner in human cancer cells (Fig.…”