Methyl jasmonate and its potential in cancer therapy

Zhang, Meng; Zhang, Michael W; Zhang, Lili; Zhang, Lingrui

doi:10.1080/15592324.2015.1062199

Cited by 21 publications

(11 citation statements)

References 24 publications

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“…Mitochondria of cancer cells seem to be the main target of MeJA action, where it stimulates reactive oxygen species (ROS) production, binds to and detaches mitochondria-bound hexokinase, induces cytochrome c release, causes ATP depletion and finally cell death [ 1 , 5 , 6 ]. The association between cancer and chronic inflammation has been widely accepted and the anticancer activity of MeJA seems to be in addition related to anti-inflammatory actions [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Sá‐Nakanishi

Soni-Neto

Moreira

et al. 2018

Oxidative Medicine and Cellular Longevity

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Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent. This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. MeJA (75 to 300 mg·kg−1) was administrated orally during 18 days after arthritis induction with Freund's adjuvant. Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver. The hepatic glucokinase activity and glycolysis were increased in arthritic rats. MeJA decreased most inflammatory parameters and abolished the increased protein carbonylation in plasma and liver, diminished the increased hepatic ROS content, and restored the hepatic GSH/GSSG ratio in arthritic rats. However, the MeJA treatment decreased the hepatic glucokinase activity and glycolysis and stimulated mitochondrial ROS production in healthy and arthritic rats. Oxygen uptake was increased by MeJA only in livers from treated arthritic rats. This action may bear relation to the increased activity of mitochondrial NADP+-dependent enzymes to provide reducing equivalents for the glutathione cycle. These beneficial effects, however, are associated with a decreased glucose flux through the glycolysis in the liver of arthritic and healthy rats.

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Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Sá‐Nakanishi

Soni-Neto

Moreira

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…The natural cyclopentanone lipid has similar function but not structure. However, unlike the side effects associated with salicylates, such as aspirin, MJ can arrest the cell cycle or cause cell death in vitro and in vivo , without affecting normal cells [ 15 ]. Previous research demonstrated the anti-cancer effects of MJ and its suggested mechanisms, in breast, colon, gastric, lung, myeloid leukemia, prostate, and sarcoma cancer cells [ 16 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice

Chen

Wang

et al. 2017

Oncotarget

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Methyl jasmonate has recently been found to have anti-cancer activity. Methyl jasmonate detached hexokinase 2 from a voltage dependent anion channel causing a reduction in mitochondrial transmembrane potential that led to the release of cytochrome C and apoptosis inducing factor resulting in intrinsic apoptosis. Blocked adenosine triphosphate synthesis caused by mitochondrial injury hampered oxidative phosphorylation and led to cell necrosis. The results were applied to the in vivo treatment of nude mice with a satisfactory effect. Collectively, our results suggest that methyl jasmonate may be an adjuvant therapy for liver tumors due to its mechanism in cancer cells compared to that in normal cells: The major function is to inhibit glycolysis instead of changing aerobic metabolism.

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“…Lastly, several plant hormones have been shown to have bioactivity in other species (e.g. auxin has been implicated in cancer [405][406][407], SA and its derivatives have an anti-inflammatory effects in humans [408], ABA is included in nutraceuticals for glycemic control [409,410], JA and its derivatives promote apoptosis of human cancer cells [411][412][413], and SL analogs have anti-cancer activity [414,415] and induce hyphal branching in AM fungi [318]). It is reasonable that those PGRs targeting proteins with functional and structural conservation across species might also act as regulators in multiple species.…”

Section: Achievements and Prospects Of Chemical Geneticsmentioning

confidence: 99%

Chemical regulators of plant hormones and their applications in basic research and agriculture*

Jiang

Asami

2018

Bioscience, Biotechnology, and Biochemistry

119

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Plant hormones are small molecules that play versatile roles in regulating plant growth, development, and responses to the environment. Classic methodologies, including genetics, analytic chemistry, biochemistry, and molecular biology, have contributed to the progress in plant hormone studies. In addition, chemical regulators of plant hormone functions have been important in such studies. Today, synthetic chemicals, including plant growth regulators, are used to study and manipulate biological systems, collectively referred to as chemical biology. Here, we summarize the available chemical regulators and their contributions to plant hormone studies. We also pose questions that remain to be addressed in plant hormone studies and that might be solved with the help of chemical regulators.

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Methyl jasmonate and its potential in cancer therapy

Cited by 21 publications

References 24 publications

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Anti‐Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice

Chemical regulators of plant hormones and their applications in basic research and agriculture*

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