Plant–Virus–Vector Interactions

Rajarapu, Swapna Priya; Ullman, Diane E.; Uzest, Marilyne; Rotenberg, Dorith; Ordaz, Norma A.; Whitfield, Anna E.

doi:10.1002/9781119818526.ch7

Cited by 6 publications

(4 citation statements)

References 215 publications

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“…There is ample evidence of vector manipulations by plant viruses that alter vector behaviour, physiology and virus transmission. These effects can occur indirectly through plant-mediated mechanisms or directly within the vector following virus acquisition (reviewed in [13,14]). Several studies have demonstrated the occurrence of vector manipulations by plant viruses across various pathosystems involving aphids [15][16][17][18], whiteflies [19] and thrips [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Beet curly top virus affects vector biology: the first transcriptome analysis of the beet leafhopper

Han,

Cui,

Withycombe

et al. 2024

Journal of General Virology

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Curly top disease, caused by beet curly top virus (BCTV), is among the most serious viral diseases affecting sugar beets in western USA. The virus is exclusively transmitted by the beet leafhopper (BLH, Circulifer tenellus) in a circulative and non-propagative manner. Despite the growing knowledge on virus-vector interactions, our understanding of the molecular interactions between BCTV and BLH is hampered by limited information regarding the virus impact on the vector and the lack of genomic and transcriptomic resources for BLH. This study unveils the significant impact of BCTV on both the performance and transcriptome response of BLHs. Viruliferous BLHs had higher fecundity than non-viruliferous counterparts, which was evident by upregulation of differentially expressed transcripts (DETs) associated with development, viability and fertility of germline and embryos in viruliferous insects. Conversely, most DETs associated with muscle movement and locomotor activities were downregulated in viruliferous insects, implying potential behavioural modifications by BCTV. Additionally, a great proportion of DETs related to innate immunity and detoxification were upregulated in viruliferous insects. Viral infection also induced notable alterations in primary metabolisms, including energy metabolism, namely glucosidases, lipid digestion and transport, and protein degradation, along with other cellular functions, particularly in chromatin remodelling and DNA repair. This study represents the first comprehensive transcriptome analysis for BLH. The presented findings provide new insights into the multifaceted effects of viral infection on various biological processes in BLH, offering a foundation for future investigations into the complex virus-vector relationship and potential management strategies for curly top disease.

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Section: Introductionmentioning

confidence: 99%

Beet curly top virus affects vector biology: the first transcriptome analysis of the beet leafhopper

Han,

Cui,

Withycombe

et al. 2024

Journal of General Virology

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“…Virus diseases account for nearly half of all plant diseases. Virus attack can cause huge losses to various of crops worldwide 1,2 . Among the most hazardous plant viruses, tobacco mosaic virus (TMV) can cause massive economic losses to tobacco, pepper, cucumber, and some ornamental crops globally 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…Virus attack can cause huge losses to various of crops worldwide. 1,2 Among the most hazardous plant viruses, tobacco mosaic virus (TMV) can cause massive economic losses to tobacco, pepper, cucumber, and some ornamental crops globally. 3,4 Since plants have not developed an immune systems, it is difficult for plants to inhibit virus proliferation.…”

Section: Introductionmentioning

confidence: 99%

C‐Alkylated flavonoids from the whole plants of Desmodium caudatum and their anti‐TMV activity

Xiong

et al. 2023

Pest Management Science

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BackgroundNatural products are important sources of biopesticides to control plant virus, and flavonoids are identified as promising anti‐tobacco mosaic virus (TMV) agents. Since Desmodium caudatum is a rich source of flavonoids, this study focuses on the discovery of the new anti‐TMV active flavonoids from D. caudatum and their possible mode of action.ResultsThree new (compounds 1–3) and nine known (compounds 4–12) C‐alkylated flavonoids were isolated from D. caudatum. To the best of our knowledge, the framework of 1–3 was reported in natural products for the first time. In addition, 1–3, 5, and 6 showed notable anti‐TMV activity with inhibition rates in the range of 35.8–64.3% at a concentration of 50 μg/mL, and these rates are higher than that of positive control (with inhibition rates of 34.6% ± 2.8). In addition, the structure–activity relationship study revealed that the (pyrrol‐2‐yl)methyl moiety on flavone can significantly increases the activity. This result is helpful to find new anti‐TMV inhibitors.ConclusionC‐Alkylated flavonoids showed potent activities against TMV with multiple modes of actions. The increase of defense‐related enzyme activities, up‐regulate the expression of defense related genes, down‐regulate the expression of Hsp70 protein by inhibiting the related Hsp genes that are involved in tobacco resistance to TMV. By the actions mentioned earlier, the infection of TMV was influenced, thereby achieving the effects of control of TMV. The successful isolation of the earlier‐mentioned flavonoids provide the new source of biopesticides to TMV proliferation, and also contribute to the utilization of D. caudatum. © 2023 Society of Chemical Industry.

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“…Proteomic methods have yielded significant advancements towards understanding the mechanisms of virus-vector interactions (Rajarapu et al, 2021; Wilson et al, 2020). Omics technologies have enabled new biological insights into mechanisms of virus replication, virus entry, antiviral host responses and viral subversion of host defenses.…”

Section: Introductionmentioning

confidence: 99%

Identification of interacting proteins of maize mosaic virus glycoprotein in its vector, Peregrinus maidis

Alviar

Rotenberg

Martin

et al. 2022

Preprint

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Rhabdovirus glycoproteins (G) serve multifunctional roles in virus entry, assembly, and exit from animal cells. We hypothesize that maize mosaic virus (MMV) G is required for invasion, infection, and spread in Peregrinus maidis, the planthopper vector. Using a membrane-based yeast two-hybrid assay, we identified 125 P. maidis proteins that physically interacted with MMV G, of which 68% matched proteins with known functions in endocytosis, vesicle-mediated transport, protein synthesis and turnover, nuclear import/export, metabolism and host defense. Physical interaction networks among conserved proteins indicated a possible cellular coordination of processes associated with MMV G translation, protein folding and trafficking. Non-annotated proteins contained predicted functional sites, including a diverse array of ligand binding sites. Cyclophilin A and apolipophorin III co-immunoprecipitated with MMV G, and each showed different patterns of co-localization with G in insect cells. This study describes the first protein interactome for a rhabdovirus spike protein and insect vector.

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Plant–Virus–Vector Interactions

Cited by 6 publications

References 215 publications

Beet curly top virus affects vector biology: the first transcriptome analysis of the beet leafhopper

Beet curly top virus affects vector biology: the first transcriptome analysis of the beet leafhopper

C‐Alkylated flavonoids from the whole plants of Desmodium caudatum and their anti‐TMV activity

Identification of interacting proteins of maize mosaic virus glycoprotein in its vector, Peregrinus maidis

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