Plantar Fascia Thickness, a Measure of Tissue Glycation, Predicts the Development of Complications in Adolescents With Type 1 Diabetes

Craig, Maria E.; Duffin, Anthony C.; Gallego, Patricia; Lam, Alan; Cusumano, Janine; Hing, Stephen; Donaghue, Kim C.

doi:10.2337/dc07-2168

Cited by 47 publications

(39 citation statements)

References 26 publications

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“…Diabetes mellitus was reported as a risk factor for CS in this meta-analysis. Thickening of the plantar fascia has been shown in patients with T2DM (18). We found an increased ratio of neuropathy in diabetic patients who have CS.…”

Section: Discussionsupporting

confidence: 51%

Increased Calcaneal Spur Frequency in Patients with Obesity and Type-2 Diabetes Mellitus

Aydoğdu¹,

Akbulut²,

Ege³

et al. 2014

Turk J Phys Med Rehab

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Objective: Obesity is a risk factor for calcaneal spur (CS) formation. Diabetes mellitus may contribute to the risk of CS due to the decreased ability of tissue repair and peripheral neuropathy. Thus, we aimed to determine the frequency of CS in asymptomatic obese subjects with and without type 2 diabetes mellitus (T2DM). Also, we tried to find the related factors of CS in patients with T2DM. Material and Methods: Ninety-three obese patients with type-2 diabetes mellitus (T2DM) and 42 obese control subjects without glucose metabolism disturbances were enrolled in the study. A questionnaire was made about the duration of T2DM, age, and occupations of the participants. Physical, laboratory, and x-ray examinations of all cases were made. SPSS 15.0 was used for statistical analyses. Results: Patients with T2DM and control groups were similar in mean age and body mass index (BMI) (p=0.196, p=0.073, respectively). The existence of CS in the T2 diabetic group was significantly higher than in the control group (p=0.023). T2 diabetic patients with CS had significantly higher neuropathy existence, mean age, and BMI than T2 diabetic patients without CS (p=0.001, p=0.016, p=0.043, respectively). There was a positive correlation between the existence of CS and peripheral neuropathy and age (p=0.025, p=0.001, respectively). Conclusion:Increased ratio of CS in obese T2 diabetic patients may be important because of the relation between CS existence and complications of diabetes mellitus. Clinicians should pay more attention to increased frequency of CS in patients with T2DM, to avoid diabetic foot complications and other malformations.

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Section: Discussionsupporting

confidence: 51%

Increased Calcaneal Spur Frequency in Patients with Obesity and Type-2 Diabetes Mellitus

Aydoğdu¹,

Akbulut²,

Ege³

et al. 2014

Turk J Phys Med Rehab

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“…Participants who attended the complications clinic between 1997 and 2002 (baseline) 8,11 and had PFT measured were eligible for inclusion in the longitudinal study. Complications assessments and PFT measurements were performed every 1 to 2 years from baseline during adolescence until transition to adult care.…”

Section: Methodsmentioning

confidence: 99%

“…11 Briefly, participants rested prone on an examination table with feet overhanging the edge and toes pointing down. A linear array high-resolution transducer was used to measure the plantar fascia.…”

Section: Measurement Of Plantar Fascia Thicknessmentioning

confidence: 99%

“…One experienced pediatric ophthalmologist graded all photographs according to the Early Treatment Diabetic Retinopathy Study adaptation of the modified Airlie House classification of diabetic retinopathy, as previously described. 11 Retinopathy was defined as the presence of at least one microaneurysm or one hemorrhage (grade 21).…”

Section: Diabetes Complications Assessmentmentioning

confidence: 99%

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Plantar Fascia Thickness is Longitudinally Associated with Retinopathy and Renal Dysfunction: A Prospective Study from Adolescence to Adulthood

Benitez‐Aguirre

Craig

Jenkins

et al. 2012

J Diabetes Sci Technol

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Abbreviations: (AER) albumin excretion rate, (AGE) advanced glycation end product, (BMI) body mass index, (DBP) diastolic blood pressure, (DCCT) Diabetes Control and Complications Trial, (GEE) generalized estimating equations, (HbA1c) glycated hemoglobin, (MA) microalbuminuria, (MV) microvascular, (OR) odds ratio, (ORPS) Oxford Regional Prospective Study, (PFT) plantar fascia thickness, (RAGE) advanced glycation end product receptors, (SBP) systolic blood pressure, (SD) standard deviation, (SDS) standard deviation scores, (T1DM) type 1 diabetes mellitus

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“…With use of ultrasound techniques to measure plantar aponeurosis, a collagenrich tissue, researchers demonstrated previously that people with diabetes have increased plantar fascia thickness (PFT) (5). Recently, this group reported that increased PFT predicted the development of microvascular complications in adolescents with type 1 diabetes and proposed abnormal PFT as a putative marker of soft-tissue glycation (6).…”

mentioning

confidence: 99%

Association Between p.Leu54Met Polymorphism at the Paraoxonase-1 Gene and Plantar Fascia Thickness in Young Subjects With Type 1 Diabetes

et al. 2008

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OBJECTIVE -In type 1 diabetes, plantar fascia, a collagen-rich tissue, is susceptible to glycation and oxidation. Paraoxonase-1 (PON1) is an HDL-bound antioxidant enzyme. PON1 polymorphisms have been associated with susceptibility to macro-and microvascular complications. We investigated the relationship between plantar fascia thickness (PFT) and PON1 gene variants, p.Leu54Met, p.Gln192Arg, and c.-107CϾT, in type 1 diabetes. RESEARCH DESIGN AND METHODS-This was a cross-sectional study of 331 adolescents with type 1 diabetes (162 male and 169 female). PFT was assessed by ultrasound, PON1 was assessed by genotyping with PCR and restriction fragment-length polymorphism, and serum PON1 activity was assessed by rates of hydrolysis of paraoxon and phenylacetate.RESULTS -Median (interquartile range) age was 15.4 (13.5-17.3) years, and diabetes duration was 7.6 (4.9 -10.6) years. The distribution of p.Leu54Met genotypes was LL 135 (40.8%), ML 149 (45%), and MM 47 (14.2%). PFT was abnormal (Ͼ1.7 mm) in 159 adolescents (48%). In multivariate analysis, predictors of abnormal PFT were ML/LL versus MM p. CONCLUSIONS -Thickening of the plantar aponeurosis occurs predominantly in overweight and male adolescents with type 1 diabetes. The MM genotype at PON1 p.Leu54Met is associated with a reduced risk of abnormal PFT.

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Plantar Fascia Thickness, a Measure of Tissue Glycation, Predicts the Development of Complications in Adolescents With Type 1 Diabetes

Cited by 47 publications

References 26 publications

Increased Calcaneal Spur Frequency in Patients with Obesity and Type-2 Diabetes Mellitus

Increased Calcaneal Spur Frequency in Patients with Obesity and Type-2 Diabetes Mellitus

Plantar Fascia Thickness is Longitudinally Associated with Retinopathy and Renal Dysfunction: A Prospective Study from Adolescence to Adulthood

Association Between p.Leu54Met Polymorphism at the Paraoxonase-1 Gene and Plantar Fascia Thickness in Young Subjects With Type 1 Diabetes

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