Plantar keratoderma as a presenting sign of pancreatic adenocarcinoma

Ulla, Jose Luis; García‐Doval, I.; Posada, Celia; Soto, Santiago; Álvarez, Carlos; Ledo, L.; Vazquez-Astray, Enrique

doi:10.1002/jcu.20377

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Other skin signs reported in pancreas-related conditions or part of a syndrome with pancreatic involvement are summarized in Table 2 [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ]. Some of them are presented as rare case reports or small case series; others such as Trousseau’s syndrome may be encountered relatively commonly in clinical practice.…”

Section: Cutaneous Manifestations In Pancreatic Diseasesmentioning

confidence: 99%

Cutaneous Manifestations in Pancreatic Diseases—A Review

Miulescu

Balaban

Şandru

et al. 2020

JCM

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Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutaneous involvement plays an important role both as a diagnostic clue for the pancreatic disease itself and serving as a prognostic factor for the severity of the condition. Recognition of these cutaneous signs is, however, far from being satisfactory, all the more as some of them are relatively rare. In the current review, we discuss skin involvement in pancreatic diseases, referring to pancreatic panniculitis, cutaneous hemorrhagic manifestations, skin metastasis, acanthosis nigricans, livedo reticularis, necrolytic migratory erythema and cutaneous fistula. We highlight the clinical characteristics, treatment and prognostic value of these lesions. Better awareness among medical specialties other than dermatology is needed for detection of the skin clues associated with pancreatic pathology.

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Section: Cutaneous Manifestations In Pancreatic Diseasesmentioning

confidence: 99%

Cutaneous Manifestations in Pancreatic Diseases—A Review

Miulescu

Balaban

Şandru

et al. 2020

JCM

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“…Bu bulgu %90 oranında malinite habercisi olup izole ise çoğu zaman akciğer kanseri ile, akantozis nigrikansla birlikteyse çoğu zaman mide kanseri ile ilişkilidir 20 . Edinsel palmoplantar keratoderma pankreatik adenokarsinom, feokromasitoma ve multipl myeloma bağlı da ortaya çıkabilmektedir [21][22][23] . Palmoplantar keratoderma histopatolojisinde yoğun hiperkeratoz, akantoz, papillomatoz ve granüler tabakada kalınlaşma saptanır.…”

Section: Palmoplantar Keratodermaunclassified

Keratinizasyon bozukluklarının paraneoplastik önemi

Ekinci¹,

Atcı²,

Baykal³

2013

TURKDERM

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ÖzetKeratinizasyon bozukluklarının önemli bölümü konjenital hastalıklar olmakla birlikte edinsel olarak ortaya çıkan keratinizasyon bozuklukları da vardır. Bunların bir çok nedeni arasında sistemik maliniteler de yer alır. Edinsel iktiyoz, Bazex sendromu ve "tripe palms" (işkembe avuç içi) paraneoplastik ilişki oranının yüksek olduğu hastalıklar arasında yer alır. Akantozis nigrikans ise malinite ile birlikte olduğunda çok şiddetli seyreder ve özel klinik görünümlere yol açar. Başka bir nedenle açıklanamayan edinsel palmoplantar keratoderma nadir de olsa paraneoplastik olabilir. Bu hastalıklara erken ve doğru tanı konması malinitelerin erken saptanmasını sağlaması açısından önem taşır. (Türk derm 2013; 47: Özel Sayı 2: 99-102) Anahtar Kelime: Keratinizasyon bozukluğu, malinite, paraneoplazi, edinsel iktiyoz, akantozis nigrikans, akrokeratozis paraneoplastika, palmoplantar keratoderma Sum maryAlthough most of the keratinization disorders are congenital diseases, there are also acquired forms of keratinization disorders. Among their multiple causes systemic malignancies deserve special attention. Acquired ichthyosis, Bazex syndrome and tripe palms are among diseases with highest ratio of paraneoplastic association. On the other hand, acanthosis nigricans has very severe and atypical presentations when associated with malignancy. Acquired palmoplantar keratoderma without any detectable cause could rarely have paraneoplastic origin. The early and correct diagnosis of these diseases is important to disclose the malignancies early. (Turkderm 2013; 47

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Much More than Trousseau Syndrome. The Broad Spectrum of the Pancreatic Paraneoplastic Syndromes

Zalatnai

Perjési

Galambos

2017

Pathol. Oncol. Res.

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When 150 years ago Armand Trousseau proposed that some thrombotic events might be the first sign of concealed visceral malignancies, these findings seemed to be just of anecdotal interest. Since then, however, we have learned that adenocarcinomas, including pancreatic cancers could be associated with a wide spectrum of paraneoplastic syndromes. They may precede the detection of the tumor, may occur simultaneously or may develop during its progression. Due to various hematologic, endocrine, cutaneous, articular, neuromuscular, renal or even psychiatric syndromes, their correct interpretation is intriguing, and because their early signs are not necessarily recognized first by oncologists, the paraneoplastic syndromes pose a diagnostic challenge. Unfortunately, we cannot generalize about their mechanisms, because the molecular backgrounds are far-reaching. In most of the cases, the pancreatic cancer cells release various factors into the bloodstream triggering the coagulation cascade. These patients frequently present with venous thromboembolism, and sometimes they are resistant to anticoagulation. The simultaneous thrombotic and bleeding evens do reflect the abnormal hemostasis. In other instances autoantibodies are formed against cutaneous, renal, neuromuscular or nervous tissues, but the mechanism of some syndromes remains unclear. Clinicians should be aware that pancreatic carcinoma may be associated with not just the Trousseau-syndrome.

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Plantar keratoderma as a presenting sign of pancreatic adenocarcinoma

Cited by 7 publications

References 5 publications

Cutaneous Manifestations in Pancreatic Diseases—A Review

Cutaneous Manifestations in Pancreatic Diseases—A Review

Keratinizasyon bozukluklarının paraneoplastik önemi

Much More than Trousseau Syndrome. The Broad Spectrum of the Pancreatic Paraneoplastic Syndromes

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