Plants and their active compounds: natural molecules to target angiogenesis

Lu, Kai; Bhat, Madhavi; Basu, Sujit

doi:10.1007/s10456-016-9512-y

Cited by 66 publications

(56 citation statements)

References 85 publications

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“…The process is important to provide nutrition and oxygen to growing tissues 26 . A wide variety of plant-based compounds have been reported to act in angiogenesis process; these compounds include polyphenols, alkaloids, terpenoids and tannins 27 . We also observed an increased wound angiogenesis in STRO-treated mice when compared with Vehicle-treated group.…”

Section: ■ Discussionmentioning

confidence: 99%

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

et al. 2017

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Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuatesinflammatory responses in cutaneous wound healing in mice 1 AbstractPurpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods:The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/ vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-β-D-glucosaminidase activities. The levels of TNF-α, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results:We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.

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Section: ■ Discussionmentioning

confidence: 99%

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

et al. 2017

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“…These molecules were shown to present a diverse array of action mechanisms, including antioxidant activity, enzyme stimulation, hormones mimicking and by interfering with DNA replication [115]. Phytochemicals have thus demonstrated positive effects in health, especially in cancer prevention [118].…”

Section: Natural Sources Of Antiangiogenic Compoundsmentioning

confidence: 99%

“…An alternative to overcome the antiangiogenic drugs resistance is by their combination with other conventional therapies, including chemotherapy or radiation [19]. Combined therapies may have a synergistic effect when compared to the single drug therapies [115]. For example, bevacizumab sometimes is used with other drugs such as 5-fluorouracil or chemotherapy, to enhance treatment against various types of cancers [116].…”

Section: Antiangiogenic Drugsmentioning

confidence: 99%

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

et al. 2018

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a b s t r a c tAngiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesisrelated pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed.

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“…Malignant tumor needs excessive blood supply for their quick proliferation and development. Therefore, angiogenesis is significant for the start, development and metastasis of a malignant tumor (Lu et al, 2016). Eosinophil normalizes the angiogenesis while the response to hypoxia which is ordinarily observed in infectious regions (Efraim and Levi-Schaffer, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…It is also crucial to the pathogenesis of a number of diseases (Lu et al, 2016). Angiogenesis irregulation causes the initiation of several diseases and furthermore progression such as, age related macular degeneration and malignant tumor (Adair and Montani 2010).…”

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confidence: 99%

Effect of ginger extract on angiogenesis using CAM assay

Bashir

Qadir

2017

Bangladesh J Pharmacol

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Research ArticleEffect of ginger extract on angioEffect of ginger extract on angioEffect of ginger extract on angiogenesis using CAM assay genesis using CAM assay genesis using CAM assay BJP IntroductionAngiogenesis is important for the typical physiological activities such as cure from injury, menstrual cycle and embryo growth. It is also crucial to the pathogenesis of a number of diseases (Lu et al., 2016). Angiogenesis irregulation causes the initiation of several diseases and furthermore progression such as, age related macular degeneration and malignant tumor (Adair and Montani 2010). Malignant tumor needs excessive blood supply for their quick proliferation and development. Therefore, angiogenesis is significant for the start, development and metastasis of a malignant tumor (Lu et al., 2016). Eosinophil normalizes the angiogenesis while the response to hypoxia which is ordinarily observed in infectious regions (Efraim and Levi-Schaffer, 2013). The tumor associated macrophages discharge many proangiogenic factors. These are the basic fibroblast growth factor, vascular endothelial growth factor-A, adrenomedullin, thymidine phosphorylase, and urokinasetype plasminogen activator. These factors initiate the angiogenic mechanism switch (Riabov et al., 2014). Cancer cells need oxygen supply and proper nutrition for their development. Tumors without oxygen availability are not able to increase their size more than 1-2 mm. Immunoglobulin G stops the vascular endothelial growth factor-A receptor in the endothelial cells. Therefore, blocks the blood supply availability towards tumor. The naturally occurring health products have multifaceted organic compounds which have the great ability to stop angiogenesis process. These communicate with different pathways which influence cell signaling, the immune system and apoptotic and stops angiogenesis.Ginger (Zingiber officinale Roscoe) belongs to family Zingiberaceae. Chemical investigation of ginger demonstrates that it consists of about 400 various complex compounds. The most significant ingredients are lipids (3-8%), terpenes and carbohydrates (50-70%) (Grzanna et al., 2005). Terpene ingredients present in the ginger consist of zingiberene, -bisabolene, -farnesene, -sesquiphellandrene and -curcumene, although phenolic ingredients consist of gingerol (23-25%), paradol, and shogaol (18-25%). Ginger also contains the amino acids, minerals and vitamins (Shukla and Singh 2007). Furthermore, ginger has been accounted concerning the illustration an ache easing to arthritis, muscle soreness and stomach pain cure. It is utilized as taste in foods and is usually recognized as AbstractAngiogenesis performs a critical role in the embryonic growth and several pathological conditions in cancer. This study evaluated the anti-angiogenic properties of the ginger extract using CAM assay. Ginger extract was prepared by methanol. Window was made after 5 days of incubation of eggs and the ginger extract was applied on day 6 at different doses (20, 50, 75 and 150 µL). SPIP software was utili...

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Plants and their active compounds: natural molecules to target angiogenesis

Cited by 66 publications

References 85 publications

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

Effect of ginger extract on angiogenesis using CAM assay

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