Plants for Female Fertility Regulation: A Review

Ansari, Aysha; Sevliya, Kiran; Mohammad, Irshad; Badar, Ayesha; Lohiya, N. K.

doi:10.3923/jpt.2017.57.75

Cited by 8 publications

(3 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is similar with the finding of Adebisi et al, 2021 who reported safety of the extract at studied doses of 200, 400 and 800 mg/kg body weight. This safety has also been demonstrated in various studies where extracts of Phyllantus family were generally administered (Ansari et al, 2017) The various doses of aqueous leaf extract of P. niruri utilized in this study demonstrated a potent antimalaria activities against P. falciparium infection. The extract at doses of 100 and 200mg/kg were effective at suppressing the induced mice malaria compared to Artemether and Lumefantrine which is the standard drug and the response was dose dependent.…”

Section: Discussionsupporting

confidence: 63%

THERAPEUTIC ACTIVITY OF AQUEOUS LEAF EXTRACT OF Phyllanthus niruri AGAINST Plasmodium falciparum

Dantala¹,

Naman²,

Sanda³

2022

FJS

View full text Add to dashboard Cite

Therapeutic activity of aqueous extract of Phyllanthus niruri against Plasmodium falciparum malarial parasite was examined In vivo. Total of 24 mice were used to test for acute toxicity of the plant extract, 4 days suppressive test and curative ability of the leaf extract. Average percentage parasitaemia of each group of mice was calculated and student's t-test statistical package was used to analyse the data obtained. Aqueous extract of P. niruri show no any sign of toxicity neither mortality observed, the plant extract exhibited high percentage chemosuppression of 76.1% at 100 mg/kg followed by 59.0% at 80 mg/kg in suppressive test. High chemosuppression was obtained at 200 mg/kg 59.09% and 100 mg/kg with 42.04% in the curative test. There was a significant (P ≤ 0.05) reduction in the number of parasitized red blood cells relative to the negative control, hence the result shows that the aqueous extracts of P. niruri possess promising antimalarial activities which can be exploited for malaria therapy, and also justifies the traditional use of the plant in malaria treatment.

show abstract

Section: Discussionsupporting

confidence: 63%

THERAPEUTIC ACTIVITY OF AQUEOUS LEAF EXTRACT OF Phyllanthus niruri AGAINST Plasmodium falciparum

Dantala¹,

Naman²,

Sanda³

2022

FJS

View full text Add to dashboard Cite

show abstract

“…Series of plants have been screened worldwide as being used for treatment of various human ailments since ancient times (Ansari et al, 2017). The use of plant extracts as fertility enhancer in humans is now on the increase, especially in developing countries, due to their accessibility, availability and affordability.…”

Section: Introductionmentioning

confidence: 99%

Cissampelos pareira ethanolic extract modulates hormonal indices, lipid profile, and oxidative parameters in transient infertility-induced female albino rats

Oladimeji,

Igbalaye,

Awote

et al. 2023

View full text Add to dashboard Cite

Cissampelos pareira is a medicinal plant with conflicting local claims regarding its usage in the management of fertility disorder. This study investigates the effect of the ethanolic extract of C. pareira on fertility indices in female albino rats. Ethanolic extract of C. pareira was administered orally for 14 days to female rats placed in different groups. Levonorgestrel (0.14mg/g) was orally administered to certain rat groups for 7 days to induce transient infertility before other treatments. The rats were sacrificed at the completion of their respective oral administration route. Blood samples were collected through cardiac puncture for hormonal and lipid profiling, which were analysed using commercial standard enzyme-linked immunosorbent assay (ELISA) kit. Organs were harvested for the assessment of oxidative parameters. Phytochemical screening reveals the presence of alkaloid, saponin, glycoside, tannin, steroid and flavonoid in the extract. The extract has no significant effect on progesterone, significantly reduced testosterone (p<0.05), but increased prolactin and estradiol concentrations (p<0.05). No significant hormonal difference in groups pre-administered levonorgestrel. The extract significantly elevated serum triglyceride, but reduced cholesterol level (p<0.05), even in groups pre-administered with levonorgestrel. The extract significantly reduced H2O2 and SOD activities (p<0.05) in the ovary and kidney respectively. Following levonorgestrel pre- administration, the extract significantly reduced H2O2 and GSH in the liver and kidney, elevated SOD activities in the liver, ovary and brain (p<0.05). This study demonstrated the antifertility properties of the ethanolic extract of Cissampelos pareira, shown by its effects of the hormonal and lipid profile, with moderate antioxidant effect.

show abstract

“…Regulation of fertility through varied products of plant origin is a new approach in the field of contraceptive development 1 . To avoid the side effects of available steroidal contraceptives and intrauterine devices, efforts have been made towards the development of new contraceptive agents from plant extracts 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

The use of plants for contraception and abortion is recorded throughout history, with contemporary reports from India and many other countries. Daucus carota is one of the several plants traditionally used for birth control. The present work was undertaken to evaluate the antifertility effect of the seeds of the plant by carrying out pharmacological studies with the methanolic extract of the seeds. The seeds of Daucus carota were extracted with methanol. The dried methanol extract was administered orally to an experimental group of Swiss albino mice for 21 days. The duration of the phases of the estrous cycle, changes in the levels of reproductive hormones (LH, FSH, prolactin, estradiol, and progesterone) and the number of litters obtained were monitored and compared with the control group of the animals. Daucus carota seed extracts prolonged the estrous cycle of the experimental group of animals with a significant increase of the duration of the diestrus phase. The number of litters produced by the experimental animals was significantly less. Moreover, the extract caused an alteration in the hormone levels with significant lowering of serum estradiol level. The present study indicates that the seed extract of Daucus carota may have a reversible antifertility effect and can impair the oogenesis.

show abstract

Plants for Female Fertility Regulation: A Review

Cited by 8 publications

References 148 publications

THERAPEUTIC ACTIVITY OF AQUEOUS LEAF EXTRACT OF Phyllanthus niruri AGAINST Plasmodium falciparum

THERAPEUTIC ACTIVITY OF AQUEOUS LEAF EXTRACT OF Phyllanthus niruri AGAINST Plasmodium falciparum

Cissampelos pareira ethanolic extract modulates hormonal indices, lipid profile, and oxidative parameters in transient infertility-induced female albino rats

Untitled

Contact Info

Product

Resources

About