Plants' natural products as alternative promising anti-Candida drugs

Soliman, Sameh S. M.; Alnajdy, Dina; El‐Keblawy, Ali; Mosa, Kareem A.; Khoder, Ghalia; Noreddin, Ayman M.

doi:10.4103/phrev.phrev_8_17

Cited by 64 publications

(49 citation statements)

References 142 publications

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“… Camphor as well as 1,8‐cineole are well‐known chemicals to have pronounced antimicrobial properties . Antifungal mechanisms of herbal products can include interference in germination, biofilming, cellular metabolism, cell wall integrity, cell membrane elasticity or induction of apoptosis …”

Section: Discussionmentioning

confidence: 99%

Comparing the effectiveness of Salvia officinalis, clotrimazole and their combination on vulvovaginal candidiasis: A randomized, controlled clinical trial

Ahangari

Farshbaf‐Khalili

Javadzadeh

et al. 2019

J of Obstet and Gynaecol

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Aim To determine the effect of vaginal tablet of Salvia officinalis, alone and in combination with Clotrimazole, on the recovery of Vulvovaginal candidiasis. Methods In this triple‐blind randomized controlled trial, 111 participants were randomly assigned into three groups of 37 patients using block randomization with block sizes of 6 and 9, and allocation ratio of 1:1:1: 100 mg vaginal tablet of Clotrimazole and Placebo (CP), 400 mg vaginal tablet of S. officinalis and Placebo (SP), and vaginal tablet of S. officinalis and Clotrimazole (SC), once daily for 7 days. On the seventh day after the treatment was ended up, Vulvovaginal candidiasis were examined by vaginal symptoms and wet test, and if positive, they were examined by culture in chrome agar Candida medium. Results Socio‐demographic characteristics was similar (P > 0.05). Thirty‐six, 36 and 35 patients, respectively in CP, SC and SP groups recruited in the study. The frequency of a positive wet test confirmed by Sabrodextrose agar medium 7 days after treatment was significantly lower in SC group than the reference group of CP (adjusted odds ratio = 0.09, 95% confidence interval: 0.93–0.932, P = 0.043). There was no significant difference between SP and CP group (P = 0.071, 95% confidence interval: 0.032–1.151, adjusted odds ratio = 0.192). Also, there was no significant difference between the three groups in terms of vaginal symptoms at the baseline (P > 0.05), however the statistical differences were indicated after the intervention in cheesy discharge, pruritus and Vulvovaginal edema (P < 0.05.(. Conclusion S. officinalis in the form of vaginal tablet, alone and when combined with Clotrimazole, can treat the Vulvovaginal Candidiasis.

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Section: Discussionmentioning

confidence: 99%

Comparing the effectiveness of Salvia officinalis, clotrimazole and their combination on vulvovaginal candidiasis: A randomized, controlled clinical trial

Ahangari

Farshbaf‐Khalili

Javadzadeh

et al. 2019

J of Obstet and Gynaecol

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“…The general resistance of Candida spp. to most available antifungal drugs [20] and the emergence of multidrug resistant C. auris [21] make urgent the need to develop novel effective anti-Candida drugs. On the other hand, most compounds synthesized nowadays are developed against C. albicans, while very few are tested against C. auris.…”

Section: Discussionmentioning

confidence: 99%

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

et al. 2020

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Candida is the most common fungal class, causing both superficial and invasive diseases in humans. Although Candida albicans is the most common cause of fungal infections in humans, C. auris is a new emergent serious pathogen causing complications similar to those of C. albicans. Both C. albicans and C. auris are associated with high mortality rates, mainly because of their multidrug-resistance patterns against most available antifungal drugs. Although several compounds were designed against C. albicans, very few or none were tested on C. auris. Therefore, it is urgent to develop novel effective antifungal drugs that can accommodate not only C. albicans, but also other Candida spp., particularly newly emergent one, including C. auris. Inspired by the significant broad-spectrum antifungal activities of the essential oil cuminaldehyde and the reported wide incorporation of azoles in the antifungal drugs, a series of compounds (UoST1-11) was designed and developed. The new compounds were designed to overcome the toxicity of the aldehyde group of cuminaldehyde and benefit from the antifungal selectivity of azoles. The new developed UoST compounds showed significant anti-Candida activities against both Candida species. The best candidate compound, UoST5, was further formulated into polymeric nanoparticles (NPs). The new formula, UoST5-NPs, showed similar activities to the nanoparticles-free drug, while providing only 25% release after 24 h, maintainng prolonged activity up to 48 h and affording no toxicity. In conclusion, new azole formulations with significantly enhanced activities against C. albicans and C. auris, while maintaining prolonged action and no toxicities at lower concentrations, were developed.

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“…Microbial growth influenced by several factors include (1) the osmotic pressure difference inside and outside the cell, (2) the cell membrane damage due to irritation, (3) changes in pH, and (4) the cell fluid diffusion. 17,[19][20][21][22] The decreased power of inhibition zone at the highest concentration of the possibility because of the rate of diffusion of active substances. In general, the diameter of inhibition zone tends to increase proportionately to the increasing level of the extract but does not occur in this extract.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antimicrobial Activity Evaluation of Mangrove Fruit (Sonneratia caseolaris L.) Extract

Ahmad¹,

Ambarwati²,

Lukman³

et al. 2018

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Introduction: Mangrove fruit (Sonneratia caseolaris L) from Sonneratiaceae family known with local name "Pidada Merah" has bioactive components. The present study aimed to evaluate the antimicrobial activity of this plant. Method: The sample was macerated using methanol, the antimicrobial activity assay was performed using agar disc diffusion method against Escherichia coli ATTC9637, Staphylococcus aureus ATTC6538, and Candida albicans ATTC10231. Results: Antimicrobial activity of Mangrove fruit methanol extract were obtained the optimum concentration of S. aureus of 80%, E. coli of 15%, and C. albicans of 30%. Conclusion: based on the results, the sample has antimicrobial properties, and this is a preliminary data for further study.

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Plants' natural products as alternative promising anti-Candida drugs

Cited by 64 publications

References 142 publications

Comparing the effectiveness of Salvia officinalis, clotrimazole and their combination on vulvovaginal candidiasis: A randomized, controlled clinical trial

Comparing the effectiveness of Salvia officinalis, clotrimazole and their combination on vulvovaginal candidiasis: A randomized, controlled clinical trial

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

In vitro Antimicrobial Activity Evaluation of Mangrove Fruit (Sonneratia caseolaris L.) Extract

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