Plants used for the treatment of diabetes in Jordan: A review of scientific evidence

Al‐Aboudi, Amal; Afifi, Fatma U.

doi:10.3109/13880209.2010.501802

Cited by 70 publications

(40 citation statements)

References 111 publications

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“…[36] Hence the evidence for a candidate potent effect of folk herbal medicine occupy in dealing to anti-diabetes. [39] Moreover, the effectiveness of folk medicine must be herbal therapies as to build few adverse effects and reduce costly for alternative hyperglycemia agents. Particularly, curcumin (bis-α,β-unsaturated β-diketone), the chief constituent of turmeric plant (C. longa), plays a significant role in prevention of various diseases including diabetes by decrease blood glucose and increase plasma insulin level, [40] while different species has been taken as anti-diabetic agents in potent and safety on therapy of patient's diabetes.…”

Section: Discussionmentioning

confidence: 99%

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia in Vitro and in Vivo

Riyaphan¹,

Jhong²,

Tsai³

et al. 2017

Preprint

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Section: Discussionmentioning

confidence: 99%

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia in Vitro and in Vivo

Riyaphan¹,

Jhong²,

Tsai³

et al. 2017

Preprint

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“…The traditional Arabic medicine is still practiced and may provide effective new compounds for treating diabetes and other diseases, as the 69 plant species that are reported in a review concerning diabetes treatment in Jordan (11). Some of these plants have been demonstrated to inhibit amylase and glucosidase activities in vitro and in vivo, including Geranium graveolens and Varthemia iphionoides (31), Pistacia atlantica, Rheum ribes and Sarcopoterium spinosum (32).…”

Section: Antidiabetic Plants Used In Traditional Medicinementioning

confidence: 99%

“…In this sense, herbal compounds appear to offer gentler means of managing metabolic disorders and, since ancient times, have been used in traditional medicine systems like Chinese, Indian ayurveda and Arabic unani (10). Therefore, evidence for a putative beneficial effect of a wide range of medicinal plants exists in relation to type 2 diabetes therapy (11). In addition to their effectiveness, herbal remedies seem to produce hardly adverse effects and present an economical alternative to the oral synthetic hypoglycemic agents.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

Etxeberría

Garza²,

Campión³

et al. 2012

Expert Opinion on Therapeutic Targets

323

179

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Importance of the field: The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcomes observed with the commercially available anti-diabetic drugs have led to the investigation of new therapeutic approaches focused on controlling postprandrial glucose levels. The use of carbohydrate digestive enzyme inhibitors from natural resources could be a possible strategy to block dietary carbohydrate absorption with less adverse effects than synthetic drugs. Areas covered in this review: This review covers the latest evidence regarding in vitro and in vivostudies in relation to pancreatic alpha-amylase inhibitors of plant origin, and presents bioactive compounds of phenolic nature that exhibit anti-amylase activity.What the reader will gain: The state of the art of the search for new pancreatic alpha amylase inhibitors of plant origin for the treatment of type 2 diabetes mellitus.Take home message: Pancreatic alpha-amylase inhibitors from traditional plant extracts are a promising tool for diabetes treatment. Many studies have confirmed the alpha-amylase inhibitory activity of plants and their bioactive compounds in vitro, but few studies corroborate these findings in rodents and very few in humans. Thus, despite some encouraging results, more research is required for developing a valuable anti-diabetic therapy using pancreatic alpha-amylase inhibitors of plant origin.Keywords: alpha-amylase; flavonoids; proanthocyanidins; tannins; type 2 diabetes mellitus 2 IntroductionDiabetes mellitus is one of the world´s major diseases, with an estimation of 347 million adults affected in 2011 (1). Type 2 diabetes mellitus, by far the most common type, is a metabolic disorder of multiple etiology characterized by carbohydrate, lipid and protein metabolic disorders that includes defects in insulin secretion, almost always with a major contribution of insulin resistance (2). These abnormalities could lead to lesions such as retinopathy, nephropathy, neuropathy, and angiopathy (3).In this context, the inhibition of carbohydrate digestive enzymes is considered a therapeutic tool for the treatment of type 2 diabetes (4). The most important digestive enzyme is pancreatic alpha-amylase (EC 3.2.1.1), a calcium metalloenzyme that catalyzes the hydrolysis of the alpha-1,4 glycosidic linkages of the starch, amylose, amylopectin, glycogen, and various maltodextrins and is responsible of most of starch digestion in humans. A second enzyme named alpha-glucosidase or maltase (EC 3.2.1.20) catalyzes the final step of the digestive process of carbohydrates acting upon 1,4-alpha bonds and giving as a result glucose (4).A positive correlation between human pancreatic alpha-amylase (HPA) activity and the increase in postprandial glucose levels has been shown, demonstrating the relevance of suppressing postprandial hyperglycemia (PPHG) in the treatment of type 2 diabetes (5). The ability of the alpha-amylase enzyme inhibitors to avoid dietary starch to be digested and absorbed in the organism has allowed to designat...

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“…The main active secondary metabolite in olive leaf extract is oleuropeinas in Fig. 1 (8). Studies have reported various pharmacological benefits of oleuropein.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Oleuropein from Olea europaea Leaf against Alloxan Induced Type 1 Diabetic in Rats

Qadir

Ali

Qader

2016

Braz. arch. biol. technol.

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Plants used for the treatment of diabetes in Jordan: A review of scientific evidence

Abstract: Additional in vitro and in vivo studies are needed to test the hypoglycemic activity of the plants with claimed antidiabetic activity which has not yet been evaluated. Identification of the active ingredients of potent plants might generate lead compounds in drug discovery and development.

Cited by 70 publications

References 111 publications

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia <em>in Vitro </em>and <em>in Vivo</em>

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia <em>in Vitro </em>and <em>in Vivo</em>

Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

Antidiabetic Effect of Oleuropein from Olea europaea Leaf against Alloxan Induced Type 1 Diabetic in Rats

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