Plants with Oral Hypoglycaemic Action

Hypoglycaemic and Hypolipidaemic Effects of an Ethylacetate Fraction of Artocarpus heterophyllus Leaves

“…Methanol fraction also had significant activity similar to the aqueous fraction, but the initial hypoglycaemic effect (+1 hr) was more prominent in the aqueous fraction (30% vs 16%). In experiments carried out by Fernando et al [17] with the crude extract of A. heterophyllus leaves, the fasting blood glucose levels of normoglycaemic rats were reduced by 24% at +3hr. However, this reduction was obtained with a higher dose of 10g/kg body weight of A. hetertophyllus starting material.…”

“…This traditional claim was first scientifically validated by the investigations carried out by Fernando et. al [17] which demonstrated the hypoglycaemic potential of the leaf extract. This preliminary work has been followed by many other studies which have provided insights into the efficacy, safety, mechanisms of action and the presence of other bioactivities of therapeutic potential in A. heterophyllus leaves.…”

The Effect of Herbs by Charantin Product for Controlling the Blood Sugar Levels among Diabetic Patients in Ubon Ratchathani Province

“…Garlic, a sulfur-containing compound is responsible for its pungent odour and it has been shown to have significant hypoglycemic activity 6 . This effect is thought to be due to increased hepatic metabolism, increased insulin release from pancreatic beta cells and/or insulin sparing effect 7 . Aqueous homogenate of garlic (10 ml/kg/day) administered orally to sucrose fed rabbits (10 g/kg/day in water for two months) significantly increased hepatic glycogen and free amino acid content, decreased fasting blood glucose, and triglyceride levels in serum in comparison to sucrose controls 8 .…”

From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM

“…Over the last two decades, several comprehensive reviews [3][4][5][6] have been written on the evidence that higher plants are of use in the treatment of diabetes, providing discussions of the botany, phytochemistry, pharmacology, and in some cases, toxicology, of the botanical agents. Literally hundreds of extracts of higher plants used in folk medicine for diabetes (or active principles derived from these plants) have been screened for their biologic activity in both in vitro and in vivo assays.…”

“…In this context, evidence has been published [3][4][5][6] that a wide array of plant-derived active principles, representing numerous classes of chemical compounds, demonstrate activity consistent with their possible use in the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Among the classes of chemical compounds isolated from plants with documented biological activity are alkaloids, glycosides, galactomannan gum, polysaccharides, peptidoglycans, hypoglycans, guanidine, steroids, carbohydrates, glycopeptides, terpenoids, amino acids, and inorganic ions.…”