Plaque‐type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma

Suwattee, Pitiporn; McClelland, Matthew C.; Huiras, Erin E.; Warshaw, Erin M.; Lee, Peter K.; Kaye, Valda N.; McCalmont, Timothy H.; Niehans, Gloria A.

doi:10.1111/j.1600-0560.2007.00843.x

Cited by 25 publications

(37 citation statements)

References 17 publications

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“…Histopathologically, the deep and plaque types can be mistaken for microcystic adnexal carcinoma. 68,69 We did not identify any unusual variants of syringoma, such as giant, plaque-like, or clear cell variants.…”

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confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge.Objective.-To determine the incidence of various vulvar adnexal lesions.Design.-We performed a retrospective review of the cases at our institution.Results.-A total of 189 vulvar adnexal lesions were identified. Most of these lesions were benign (133 of 189; 70%), with hidradenoma papilliferum being the most common, followed by syringoma and various types of cysts. Rare cases of tubular adenoma, poroma, spiradenoma, hidradenoma, cylindroma, sebaceoma, and trichoepithelioma were identified. Malignant adnexal neoplasms comprised the remaining 30% (56 of 189) of the cases. Extramammary Paget disease was the most common (49 of 56), and 29% (14 of 49) demonstrated an invasive component. Rare cases of basal cell carcinoma, sebaceous carcinoma, apocrine carcinoma, adenoid cystic carcinoma, and spiradenocarcinoma were identified.Conclusions.-In this retrospective review, we identified several benign entities that have not been previously reported on the vulva, namely pilomatricoma, poroma, spiradenoma, and sebaceoma. Hidradenoma papilliferum and extramammary Paget disease were the most common benign and malignant adnexal neoplasms, respectively. The spectrum of various vulvar adnexal lesions appears to reflect the frequency of the underlying glandular elements.

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confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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“…There are no accepted differences in immunohistochemical profile between syringoma and MAC/SC, further emphasizing the need for optimal biopsy specimens. This difficulty has recently been highlighted by Suwattee et al, 33 who reported 2 cases of plaquetype syringoma initially misdiagnosed as MAC. In our patients, the combination of the clinical presentation and classic histological features on adequate biopsy specimens aids in accurate diagnosis and highlights the unique clinicopathological features of this rare manifestation of syringoma.…”

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confidence: 96%

Eruptive Syringoma of the Penis. A Report of 2 Cases and a Review of the Literature

Petersson¹,

Mjörnberg²,

Kazakov³

et al. 2009

The American Journal of Dermatopathology

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Syringoma exclusively located to the penis is an extraordinary rare dermatological condition, and only 6 patients with syringoma exclusively located to the penis have been published previously. Light microscopical examination of routine hematoxylin and eosin-stained sections from punch biopsies with adequate depth from 2 patients was performed. Classical syringoma was diagnosed. The lesions occurred in an eruptive fashion in both patients on the dorsal and lateral aspects of the penis shaft. There was a variation in clinical appearances ranging from yellow-white papules, a few millimeter in size to, in one of the patients, formation of several slightly elevated plaques, 10 mm in size, with a brownish-red color. We describe clinicopathological features of 2 patients with syringoma exclusively located to the penis. These are compared with all the previously published cases. Clinical and histopathological differential diagnoses are discussed, and a literature review is presented.

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“…MAC typically occurs on the head and neck, particularly the central face, in middle‐aged patients and presents as an indurated single plaque. Plaque‐like syringomas can be misdiagnosed histologically as MAC 5 . It is therefore important to obtain an adequate biopsy specimen, as differentiating between the two diagnoses can be difficult, particularly with superficial biopsies when infiltrative growth patterns and perineural extension cannot be accurately assessed.…”

Section: Discussionmentioning

confidence: 99%

Unusual vulval papules

Benton

Calonje

Neill

et al. 2011

Clinical and Experimental Dermatology

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Plaque‐type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma

Abstract: Our cases are discussed in the context of histopathologic diagnosis. Detailed histopathologic findings of syringoma, as well as other considerations in the differential diagnosis, are reviewed. We also include a review of all cases of plaque-type syringoma published to date.

Cited by 25 publications

References 17 publications

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Eruptive Syringoma of the Penis. A Report of 2 Cases and a Review of the Literature

Unusual vulval papules

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