1961
DOI: 10.1210/jcem-21-6-684
|View full text |Cite
|
Sign up to set email alerts
|

Plasma 17-Hydroxycorticosteroids in Cushing's Syndrome*

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

1
11
0

Year Published

1963
1963
1974
1974

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 54 publications
(12 citation statements)
references
References 17 publications
1
11
0
Order By: Relevance
“…Some workers have reported relatively lower mean P-S chromogens in plasma for the obese than the lean (Szenas & Pattee, 1959); others have found that they are within the normal range (Migeon et al, 1963;Schultz et al, 1964). The observation that some subjects with Cushing's syndrome may have values within the normal range confirms the studies of several other workers (Ekman et al, 1961 ;Kornel, 1969). Similarly the finding that a few subjects with Cushing's syndrome may maintain day-night variation of plasma corticosteroids, and that it may be absent in some apparently normal subjects and in cases of obesity, has been noted (Ekman et al, 1961 ;Schultz et al, 1964;McHardy-Young et al, 1967;Jackson & Mowatt, 1970;Hankin et al, 1972).…”
Section: Discussionsupporting
confidence: 87%
See 2 more Smart Citations
“…Some workers have reported relatively lower mean P-S chromogens in plasma for the obese than the lean (Szenas & Pattee, 1959); others have found that they are within the normal range (Migeon et al, 1963;Schultz et al, 1964). The observation that some subjects with Cushing's syndrome may have values within the normal range confirms the studies of several other workers (Ekman et al, 1961 ;Kornel, 1969). Similarly the finding that a few subjects with Cushing's syndrome may maintain day-night variation of plasma corticosteroids, and that it may be absent in some apparently normal subjects and in cases of obesity, has been noted (Ekman et al, 1961 ;Schultz et al, 1964;McHardy-Young et al, 1967;Jackson & Mowatt, 1970;Hankin et al, 1972).…”
Section: Discussionsupporting
confidence: 87%
“…Elevated urinary 17-OHCS have been reported in a significant number of obese subjects (Simkin, 1961;Baird, 1963;McHardy-Young, Harris, Lessof & Lyne, 1967) and in most instances of Cushing's syndrome (Ekman et al, 1961 ;Ernest, 1966). However, a marked daily variation in urinary 17-OHCS excretion can occur and repeated estimations show that the value may be within the control range on some days (Ernest, 1966).…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Yet when these assays are taken as a group, the mean value (0.62 mU per 100 ml) is significantly greater than the mean value (0.25 mU per 100 ml) of a group of normal subjects at 6 a.m. Patients with Cushing's disease lack diurnal variation in plasma 17-OHCS (21). Since 17-OHCS secretion is apparently a function of ACTH in these patients, probably they also lack normal diurnal variation in ACTH secretion.…”
Section: Discussionmentioning
confidence: 80%
“…INTRODUCTION During the last few years it has become apparent that there are a number of characteristic abnormalities in the control of adrenocortical function in patients with Cushing's syndrome associated with bilateral adrenal hyperplasia (Cushing's disease). These include the observation that the normal diurnal changes of plasma cortisol levels may be absent in these patients (Ekman, Hakansson, McCarthy, Lehmann & Sjogren, 1961) and that they have a diminished sensitivity to the suppressive effects of exogenous corticosteroids on corticotrophin release (Liddle, 1960). More 16 V. H. T. James, J. Landon, V. Wynn and F. C. Greenwood it has been found that they do not have a normal adrenal response to insulin-induced hypoglycaemia (Landon, James & Stoker, 1965;Bethge, Winklemann & Zimmer¬ mann, 1966).…”
mentioning
confidence: 99%