Plasma 25-hydroxyvitamin D level and the risk of frailty among Chinese community-based oldest-old: evidence from the CLHLS study

Xiao, Qi; Wu, Meiliyang; Cui, Jinrui; Yuan, Mengmei; Chen, Ye; Zeng, Tieying

doi:10.1186/s12877-020-01523-w

Cited by 7 publications

(4 citation statements)

References 47 publications

(80 reference statements)

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“…Additionally, multidimensional logistic regression models indicated a significant inverse relationship between the level of 25(OH)D and the risk of frailty and geriatric syndrome (74).…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Sex differences in vitamin D metabolism, serum levels and action

Wierzbicka

Oczkowicz

2022

Br J Nutr

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The ubiquity of vitamin D metabolizing enzymes and vitamin D receptors in mammalian organisms suggests that vitamin D has pleiotropic effects. There are quite a few studies indicating the anticancer, cardioprotective and anti-diabetic effects of vitamin D, however, the best-documented actions of vitamin D are the regulation of calcium-phosphate balance and its effect on immune function. Vitamin D levels in organisms are modulated by many environmental and nonenvironmental factors. One potential factor that may influence vitamin D levels and effects is the sex of the individuals studied. This review focuses on the scientific evidence indicating different synthesis and metabolism of vitamin D in females and males, mainly from PubMed database sources. The article verifies the sex differences in vitamin D levels reported around the world. Moreover, the different effects of vitamin D on the musculoskeletal, cardiovascular, nervous, and immune systems, as well as cancer in males and females, were discussed. Most studies addressing sex differences in vitamin D levels and effects are observational studies with conflicting results. Therefore, carefully designed clinical trials and experiments on animal models should be carried out to determine the role of nonenvironmental factors that may differentiate vitamin D levels in females and males.

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“…Additionally, multidimensional logistic regression models indicated a significant inverse relationship between the level of 25(OH)D and the risk of frailty and geriatric syndrome (74).…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Sex differences in vitamin D metabolism, serum levels and action

Wierzbicka

Oczkowicz

2022

Br J Nutr

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“…Levels of total cholesterol are inversely associated with plasma 25-hydroxyvitamin D levels, 40 which are an important Open access marker for frailty among Chinese community-dwelling older adults. 41 Levels of total cholesterol are also inversely associated with lean body mass, 42 which is important to determine risks of falls in older Asian adults. 43 However, plasma 25-hydroxyvitamin D and lean body mass were not measured in the CHARLS, so we were not able to examine whether these two biomarkers may explain the association between levels of total cholesterol and fall events in this study.…”

Section: Discussionmentioning

confidence: 99%

Risk of falls in 4 years of follow-up among Chinese adults with diabetes: findings from the China Health and Retirement Longitudinal Study

et al. 2021

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ObjectivesThis study was to determine the incidence of falls and identify baseline factors increased risk for incident falls over time among people with diabetes.DesignThis study was a secondary analysis using the baseline and 4 years of follow-up data from the China Health and Retirement Longitudinal Study (CHARLS).SettingA nationally representative survey of 17 500 Chinese residents aged 45 years and older were recruited in the baseline national survey in 2011. These participants were followed up every 2 years.ParticipantsA total of 1238 middle-aged and older adults with diabetes and no history of falls at baseline were included in the current study.Primary and secondary outcome measuresInformation on incidence of falls and medical treatment resulting from falls were determined by self-report.ResultsThe findings showed that the incidence of falls was 29.4% during 4 years of follow-up. Participants with incident falls were younger, were more likely to be women, had lower education level and were less likely to be current drinkers. In addition, former drinkers were 2.22 times more likely to fall. Socially active individuals were 47% less likely to fall compared with those without social activities. Every 5 kg increase in grip strength was associated with a 13% lower risk of falls. A 10 mg/dL higher total cholesterol and 1 mg/dL higher blood urea nitrogen were associated with a 4% and 6% higher risk of falls. Finally, participants with depressive symptoms were 1.47 times more likely to fall compared with those without depressive symptoms.ConclusionsThese findings underscore the importance of developing a fall prevention programme for those with diabetes, and this programme should address potentially modifiable risk factors, including levels of total cholesterol, blood urea nitrogen, social activity, depressive symptoms and grip strength.

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“…However, if it is difficult to completely reverse the phenomenon, thereby necessitating the development of a convenient and rapid early warning tool. Xiao et al [ 15 ] pointed out that vitamin D deficiency or insufficiency is positively correlated with cognitive frailty, while Chye et al [ 16 ] showed that lack of vitamins C and E could easily lead to cognitive frailty in the elderly. However, these risk factors need to be detected by the instrument.…”

Section: Introductionmentioning

confidence: 99%

Construction and validation of cognitive frailty risk prediction model for elderly patients with multimorbidity in Chinese community based on non-traditional factors

Peng

Zhou²,

Xiong³

et al. 2023

BMC Psychiatry

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Background and objectives Early identification of risk factors and timely intervention can reduce the occurrence of cognitive frailty in elderly patients with multimorbidity and improve their quality of life. To explore the risk factors, a risk prediction model is established to provide a reference for early screening and intervention of cognitive frailty in elderly patients with multimorbidity. Methods Nine communities were selected based on multi-stage stratified random sampling from May–June 2022. A self-designed questionnaire and three cognitive frailty rating tools [Frailty Phenotype (FP), Montreal Cognitive Assessment (MoCA), and Clinical Qualitative Rating (CDR)] were used to collect data for elderly patients with multimorbidity in the community. The nomogram prediction model for the risk of cognitive frailty was established using Stata15.0. Results A total of 1200 questionnaires were distributed in this survey, and 1182 valid questionnaires were collected, 26 non-traditional risk factors were included. According to the characteristics of community health services and patient access and the logistic regression results, 9 non-traditional risk factors were screened out. Among them, age OR = 4.499 (95%CI:3.26–6.208), marital status OR = 3.709 (95%CI:2.748–5.005), living alone OR = 4.008 (95%CI:2.873–5.005), and sleep quality OR = 3.71(95%CI:2.730–5.042). The AUC values for the modeling and validation sets in the model were 0. 9908 and 0.9897. Hosmer and Lemeshow test values for the modeling set were χ2 = 3.857, p = 0.870 and for the validation set were χ2 = 2.875, p = 0.942. Conclusion The prediction model could help the community health service personnel and elderly patients with multimorbidity and their families in making early judgments and interventions on the risk of cognitive frailty.

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Plasma 25-hydroxyvitamin D level and the risk of frailty among Chinese community-based oldest-old: evidence from the CLHLS study

Cited by 7 publications

References 47 publications

Sex differences in vitamin D metabolism, serum levels and action

Sex differences in vitamin D metabolism, serum levels and action

Risk of falls in 4 years of follow-up among Chinese adults with diabetes: findings from the China Health and Retirement Longitudinal Study

Construction and validation of cognitive frailty risk prediction model for elderly patients with multimorbidity in Chinese community based on non-traditional factors

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