Plasma adipocytokines and antioxidants-status in Korean overweight and obese females with dyslipidemia

Abstract

BACKGROUD/OBEJECTIVESIt is hypothesized that obese people with dyslipidemia is more likely to have increased oxidative stress and decreased antioxidant status, in comparison with the controls who were obese without dyslipidemia. Thus, the aims of the present study were to determine the dietary intakes, plasma adipokines, and antioxidative systems between obese with dyslipidemia and obese without dyslipidemia were investigated.SUBJECTS/METHODSFemale subjects who were between 20 and 55 years old, and whose BMI was 23 or greater were recruited. Subjects who met the criteria of BMI ≥ 23, total cholesterol ≥ 200 mg/dL, LDL cholesterol ≥ 130 mg/dL, and TG ≥ 110 mg/dL were categorized Obese with dyslipidemia. Anthropometric measurements and blood biochemical tests were conducted. The diet survey was conducted by a trained dietitian using two days of 24 hour dietary recall. The lipid peroxidation, the plasma total antioxidant capacity (TAC), the activities of antioxidantive enzymes, and various antioxidantive vitamins levels were determined.RESULTSPlasma adiponectin and leptin levels were also determined. There were no significant differences for age, Body Mass index (BMI), and body fat (%), waist-size between two groups. Obese with dyslipidemia had significantly high levels of total cholesterol, triglyceride, LDL-cholesterol, the ratio of total cholesterol/HDL-C, and the ratio of HDL-C/LDL-C, respectively. Blood alkaline phosphatase level was statistically different between the two groups (P < 0.05). No statistical significance in dietary intake between two groups was shown. In case of obese with dyslipidemia group, the levels of GSH-Px (P < 0.05) and catalase (P < 0.05) as well as adjusted blood retinol (P < 0.05) and tocopherol level (P < 0.05) were significantly low. However, the plasma concentration of leptin was significantly high (P < 0.05).CONCLUSIONSObesity with dyslipidemia was shown to have high arthtrogenic index, depleted antioxidant status, and higher blood leptin levels which suggest higher risks of oxidative stress and cardiovascular diseases.

Evaluation of Serum Lipid Profile and Malondialdehyde Levels in Obesed Adults

“…However, in this study there was a significant decrease in TAC in relation to BMI. This is in line with Kelly et al (28) who reported a significant decrease in TAC among obese children with multimetabolic syndrome, this agrees with the findings of Wha Ha et al (29).…”

Inflammatory and Oxidative Responses in Pregnancies With Obesity and Periodontal Disease

“…36 Oxidative stress is due to an imbalance between increased ROS levels and host antioxidant defenses, resulting in cell damage. [37][38][39] The TAC is a measure of the combination of endogenous and exogenous antioxidant molecules in extracellular fluids, and it has been studied in both plasma and saliva in relation to pathological status. [40][41][42][43][44] Specifically, TAC assay has been studied to characterize the pathologic state in the saliva of pregnant women with diabetes.…”

Evaluación del estado nutricional antropométrico de madres en período de lactancia y su relación con el estado nutricional de vitaminas liposolubles A y E

“…Hay más información disponible en niños japoneses de edad escolar, en hombres y mujeres de Nepal con un rango etario entre 10 y 68 años, en mujeres mexicanas entre 30 y 45 años, en niños filipinos de edad escolar, en mujeres coreanas entre 20 y 55 años, en hombres y mujeres entre 46 y 67 años, en mujeres en edad fértil y embarazadas entre 25 y 35 años, en niños chinos escolares 67,70,[76][77][78][79][80][81] .…”

“…Sin embargo, la vitamina E ajustada a lípidos no tuvo asociación con ningún indicador antropométrico. Si comparamos con mujeres coreanas, con IMC ≥ 23 kg/m 2 , dislipémicas, tuvieron menores niveles de α-tocoferol/CT y retinol/CT 79 . En un estudio de 276 mujeres de 46-67 años se encontró una media de IMC de 25,4 ± 0,2 kg/m 2 , %MG de 31,6 ± 0,3, CC de 77,9 ± 0,7 cm (todos los valores un poco más bajos que en nuestro estudio).…”