Plasma adiponectin concentration before and after successful kidney transplantation

Chudek, Jerzy; Adamczak, Marcin; Karkoszka, Henryk; Budziński, G.; Ignacy, Witold; Funahashi, Tohru; Matsuzawa, Yūji; Cierpka, Lech; Kokot, F; Wiȩcek, Andrzej

doi:10.1016/j.transproceed.2003.08.001

Cited by 121 publications

(112 citation statements)

References 16 publications

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“…These findings were interpreted as glucocorticoids and other immunosuppressive drugs affecting the secretion and biodegradation of adiponectin and kidneys having part in elimination of this molecule. 34,41 In the present study, adiponectin levels were significantly higher in all the patient groups than those of the controls and there were not any significant differences among the patient groups. In parallel with our results, Diez et al 42 and…”

Section: Discussioncontrasting

confidence: 41%

“…This finding is in contrast with other studies reporting reduced adiponectin levels after transplantation. 34, 40 Chudek et al 41 found significantly reduced levels in adiponectin (from 20.8 ± 8.3 lg/mL to 15.7 ± 7.0 lg/mL) after (29 ± 14 days) transplantation of patients under HD, however they did not compare their post-transplantation results with those of the healthy control group (8.7 ± 4.8 lg/mL). Several studies have shown that kidney transplantation was followed by a significant reduction of plasma adiponectin level; however, no correlation was found between plasma adiponectin levels and serum creatinine level or glomerular filtration rate in those reports.…”

Section: Discussionmentioning

confidence: 97%

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Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD) including kidney transplant recipients (KTR). Secondary lipid metabolism disorders, endothelial dysfunction, and inflammation enhance the risk of CVD development in these patients. The aim of the present study was to investigate the lipid profile, adiponectin, leptin, nitric oxide (NO), and high sensitivity C-reactive protein (hs-CRP) levels in KTR and to compare these parameters with those of the patients with chronic renal failure (CRF), hemodialysis (HD) patients, and healthy controls. Methods: Serum adiponectin and leptin levels were measured by radioimmunoassay; hs-CRP was determined immunoturbidimetrically. Determination of NO was based on the Griess reaction. Results: Compared with the control group, serum NO and adiponectin levels were significantly higher in the KTR, CRF, and HD groups; hs-CRP levels were significantly higher in the KTR and HD groups; leptin levels were significantly higher in the KTR. In addition, serum NO level was significantly higher in the KTR compared to CRF cases. Adiponectin correlated positively with high density lipoprotein-cholesterol in the control and patient groups. A positive correlation was observed between hs-CRP and NO in the KTR and the patients with CRF. Serum adiponectin levels were inversely correlated with hs-CRP and leptin in the HD group. Conclusion: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients.

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Section: Discussioncontrasting

confidence: 41%

Section: Discussionmentioning

confidence: 97%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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“…However, renal involvement appears likely. Non-diabetic patients with end-stage renal failure (ESRF) have approximately a two-fold elevated serum level [29], which decreases towards control values after successful kidney transplantation [30]. Furthermore, a relationship between serum ADPN and kidney function, as estimated by serum creatinine or creatinine clearance, has been observed previously in women with dyslipidaemia [31], subjects with hypertension [32] and patients with type 2 diabetes [21], and as shown here this relationship also appears to be valid in patients with type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications

et al. 2005

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Aims/hypothesis: Low serum adiponectin (ADPN) has been associated with increased risk of cardiovascular disease (CVD) and retinopathy in patients with type 2 diabetes mellitus. In type 1 diabetic patients, the relationship between ADPN and the presence of vascular complications is largely unknown. Methods: We investigated the relationship between serum ADPN and the presence of retinopathy, nephropathy and CVD in patients with type 1 diabetes, divided into matched groups with normoalbuminuria and no retinopathy (n=67), simplex retinopathy (n=106) or proliferative retinopathy (n=19), and nephropathy with simplex (n=62) or proliferative retinopathy (n=137). Healthy control subjects (n=25) were included. Results: Serum ADPN was increased in subjects with type 1 diabetes compared with control subjects (p<0.0001). Further, serum ADPN was higher in patients with than in those without nephropathy (p<0.0001). It was also higher in normoalbuminuric patients with than in those without proliferative retinopathy (p<0.0001). These differences remained significant after adjustment for known risk factors (p<0.03). CVD was also associated with elevated ADPN levels (p<0.05), but this difference became insignificant after risk factor adjustment. The most important predictor of serum ADPN was sex (r 2 =19%) in normoalbuminuric patients and GFR in patients with nephropathy (r 2 =18%). Conclusion/interpretation: Patients with type 1 diabetes and microvascular complications have higher serum levels of ADPN than patients without complications. It remains to be clarified whether elevated levels of ADPN are pathogenically related to the development of microvascular complications or represent a beneficial counter-regulatory response.

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“…Recently, a possible relationship between low adiponectin levels and pancreatic ␤ cell dysfunction was suggested (3,4). A negative correlation between body mass index (BMI) and adiponectin levels has been established both in the general population and in patients with renal disease (5)(6)(7)(8).…”

mentioning

confidence: 99%

“…Two previous studies addressed posttransplantation adiponectin levels (5,15), and the former reported a positive relationship between steroid dose and adiponectin levels (5). Recently, low pretransplantation adiponectin levels were shown to be associated with increased risk for posttransplantation diabetes mellitus (PTDM) (7).…”

mentioning

confidence: 99%

Hypoadiponectinemia Is Associated with Insulin Resistance and Glucose Intolerance after Renal Transplantation

Hjelmesæth

Flyvbjerg²,

Jenssen³

et al. 2006

Clinical Journal of the American Society of Nephrology

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The objectives of this analysis were (1) to assess whether low serum adiponectin concentrations are associated with insulin resistance, metabolic syndrome, and new-onset posttransplantation diabetes mellitus (PTDM) and (2) to examine the possible effects of immunosuppressive and antihypertensive therapies on circulating adiponectin levels after renal transplantation. A total of 172 consecutive previously nondiabetic renal transplant recipients were examined 3 mo after transplantation, the majority (n ‫؍‬ 167) with an oral glucose tolerance test. Serum adiponectin was measured by an in-house time-resolved immunofluorometric assay. Insulin secretion and insulin sensitivity were estimated by previously validated oral glucose tolerance test-derived indexes. One-and 6-yr follow-up data were available in subgroups of patients. Lower adiponectin levels were significantly associated with insulin resistance but not with insulinopenia. Patients with low adiponectin levels (first quartile) had significantly higher odds of PTDM (odds ratio [OR] 3.6; 95% confidence interval [CI] 1.1 to 12.7; P ‫؍‬ 0.049) and metabolic syndrome (OR 3.9; 95% CI 1.6 to 9.5; P ‫؍‬ 0.003) than patients in the upper (fourth) quartile. The increased risk for PTDM in patients with low adiponectin levels remained significant after adjustment for age, steroid dose, and family history of diabetes. Treatment with ␤ blockers was independently associated with lower serum adiponectin levels, and total steroid dose was associated with higher serum adiponectin levels. Low baseline adiponectin levels were also associated with significantly higher odds of PTDM at 6 yr (OR 6.9; 95% CI ‫؍‬ 1.1 to 41.8; P ‫؍‬ 0.037). Serum adiponectin levels correlate with posttransplantation insulin sensitivity and glucose tolerance. Glucocorticoids and ␤ blockers seem to have opposite effects on circulating adiponectin levels.

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Plasma adiponectin concentration before and after successful kidney transplantation

Cited by 121 publications

References 16 publications

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications

Hypoadiponectinemia Is Associated with Insulin Resistance and Glucose Intolerance after Renal Transplantation

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