Plasma Adiponectin Concentration in Early Pregnancy and Subsequent Risk of Hypertensive Disorders

D’Anna, Rosario; Baviera, G; Corrado, Francesco; Giordano, D.; Benedetto, A. Di; Vm, Jasonni

doi:10.1097/01.aog.0000168441.79050.03

Cited by 66 publications

(55 citation statements)

References 17 publications

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“…23,24 As a vasoactive substance reacting with its specific receptors (AdipoR1 and AdipoR2), adiponectin has important physiological roles, such as protecting vascular endothelial cells, increasing insulin sensitivity, inhibiting inflammation and inhibiting atherosclerosis. By measuring plasma adiponectin in 1842 pregnant women in early pregnancy and tracking the outcomes of their pregnancies, D'Anna et al 4 found that plasma adiponectin in patients with preeclampsia was lower than in pregnancy-induced hypertension patients and normal patients. Ramsay et al 25,26 also found that plasma adiponectin was significantly higher in preeclampsia compared with normal controls, although the adiponectin level was unrelated to adiponectin mRNA expression in the placenta.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prevention and management of preeclampsia are difficult, especially in severe cases, because the etiology and pathogenesis of preeclampsia are unclear. Recent studies indicate that the interaction of adiponectin and its receptors might have a considerable role in the pathogenesis of preeclampsia [2][3][4] because of their important physiological functions, including anti-inflammatory, anti-atherosclerotic, vascular endothelial cell protection and insulin-sensitizing effects. [5][6][7][8] Numerous single-nucleotide polymorphisms (SNPs) exist in the human adiponectin gene, located on chromosome 3q27.…”

Section: Introductionmentioning

confidence: 99%

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Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

et al. 2010

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The etiology and pathogenesis of preeclampsia remain unclear. Little is known about the possible impact of adiponectin gene polymorphisms on the pathogenesis of preeclampsia. In this study, we analyzed the association of two adiponectin singlenucleotide polymorphisms (SNPs) with preeclampsia. One hundred eighty-eight Han Chinese pregnant women were enrolled (81 normal-term, 20 mild preeclampsia and 87 severe cases). Serum adiponectin level, and adiponectin exon 2 SNP +45T/G (rs2241766) genotype and intron 2 SNP +276G/T genotype (rs1501299) and their allele distributions were tested with enzyme-linked immunosorbent assay and PCR-restriction-fragment length polymorphism, respectively. There were no significant differences among the three groups (P40.05) in genotype distribution or allele frequencies of either SNP. Systolic pressure and 24-h urinary protein were lower in TT homozygotes than those in TG+GG patients at SNP +45T/G in the severe preeclamptic group (Po0.05). Furthermore, blood pressure, serum adiponectin level and 24-h urinary protein were lower in GG homozygotes than those in TG+TT patients at SNP +276G/T in the severe preeclamptic group (Po0.05). The risk of high blood pressure (X160/110 mm Hg) and of high serum adiponectin in T-allele carriers at +276G/T in the severe preeclamptic group were 5.345 and 5.818 times higher, respectively, compared with GG patients. These data suggest that adiponectin +45T/G and +276G/T polymorphisms are associated with important clinical manifestations of preeclampsia and that polymorphism +276G/T is associated with serum adiponectin level. Taken together, these findings suggest that adiponectin gene polymorphism is involved in the pathogenesis of preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

et al. 2010

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“…Maternal (34,78) and cord (79) leptin concentrations may be elevated in preeclampsia. Adiponectin, a hormone associated with increased insulin sensitivity, is elevated in the maternal circulation late in preeclamptic compared with normal pregnancies (78); however, levels early in pregnancy may be reduced (80). The association of preeclampsia with maternal third-trimester levels of resistin, a hormone possibly involved in insulin resistance and inflammation, is equivocal (78,81).…”

Section: Prominent Hypotheses To Explain Prenatal Risk Factorsmentioning

confidence: 99%

Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary

Troisi

Potischman

Hoover

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Prenatal factors have been hypothesized to influence subsequent breast cancer development. Directly evaluating the associations of in utero exposures with risk, however, presents several methodologic and theoretical challenges, including the long induction period between exposure and disease and the lack of certainty regarding the critical timing of exposure. Indirect evaluation of these associations has been achieved by use of proxies such as gestational and neonatal characteristics. Evidence suggests that preeclampsia is associated with a reduced breast cancer risk, whereas high birth weight and dizygotic twinning seem associated with an increased risk. Asians born in Asia have substantially lower breast cancer risks than women born in the West. Although data thus far are few, what exists is not consistent with a unifying hypothesis for a particular biological exposure (such as estrogens or androgens) during pregnancy as mediating the observed associations between pregnancy factors and breast cancer risk. This suggests that additional studies of prenatal factors should seek to broaden the range of hormones, growth, and other endocrine factors that are evaluated in utero. Once candidate biomarkers are identified, assessing them with respect to breast cancer and with intermediate end points in carcinogenesis should be a priority. In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1700 -12)

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“…Since low concentrations of adiponectin are associated with obesity, insulin resistance, Type 2 diabetes, hypertension [47] and obesity-related malignancies, a possible role has been hypothesized in the pathogenesis of PE. However, its role has not yet been well defined, as contrasting results have been found [48,49].…”

Section: Prognostic Toolsmentioning

confidence: 99%

The obstetric syndromes: clinical relevance of placental hormones

Severi

Bonis

Vellucci

et al. 2013

Expert Review of Endocrinology & Metabolism

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Preterm delivery, preeclampsia and intrauterine growth restriction are the major diseases of pregnancy. A key role in their pathogenesis is played by the placenta, which is the source of hormones and other important regulatory molecules providing the metabolic and endocrine homeostasis of the fetal-placental unit. Since obstetric syndromes are characterized by important maternal and neonatal morbidity and mortality worldwide, numerous efforts have been made over the years to prevent and treat them. Due to their complex pathogenesis, however, the therapy is poor and not very effective. Therefore, great emphasis is currently given to the prevention of these diseases through the identification of biochemical and biophysical markers, among which placental factors play a crucial role. The increasing knowledge of the role of placental molecules can indeed lead to the development of new therapeutic and diagnostic tools. The obstetric syndromes: clinical relevance of placental hormonesExpert Rev. Endocrinol. Metab. 8(2), 127-138 (2013)

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Plasma Adiponectin Concentration in Early Pregnancy and Subsequent Risk of Hypertensive Disorders

Abstract: Our findings suggest a strong association between hypoadiponectinemia and the risk of hypertensive disorders in pregnancy, especially with preeclampsia.

Cited by 66 publications

References 17 publications

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary

The obstetric syndromes: clinical relevance of placental hormones

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