Plasma albumin synthesis during neonatal development of the rat

Wise, R. W.; Oliver, I.T.

doi:10.1042/bj1020760

Cited by 20 publications

(7 citation statements)

References 8 publications

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“…The synthesis of albumin by the liver increases during postnatal development (Wise and Oliver, 1967;Yeoh and Morgan, 19741, although the serum concentration is lower during this period (Uriel and Nechaud, 1973). Only some hepatocytes have been reported to be albumin-positive during development (Guillouzo et al, 1978;Valet et al, 1981).…”

Section: Hepatocyteorganelles Rer and Golgi Complexmentioning

confidence: 97%

Fine structure and function of hepatocytes during development

Kanamura

Kanai

Watanabe

1990

J. Elec. Microsc. Tech.

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This paper reviews the fine structure and function of hepatocytes during fetal and postnatal development. Bile canaliculi develop to a mature appearance during perinatal and early postnatal periods, while bile secretory function is immature at birth and develops during the postnatal period. The rough endoplasmic reticulum is prominent and remains unchanged in amount during development, and the Golgi complex is large from early stages of fetal life. The smooth endoplasmic reticulum (SER) appears shortly before birth and increases in quantity to the adult level after birth. In mouse hepatocytes, Sv (area per unit cytoplasmic volume) of SER increases in perivenular cells between 1 and 10 days of age, although it remains low in periportal cells. Similarly, Sv of total ER increases in both periportal and perivenular cells between 1 and 5 days of age and then becomes greater in perivenular than periportal cells. This suggests that the postnatal increase in the drug-metabolizing capacity occurs predominantly in perivenular hepatocytes. SER proliferates after phenobarbital (PB) administration in both perivenular and periportal cells in 3-, 5-, and 10-day-old mice, and predominantly in perivenular cells in 20-day-old and adult mice. Thus the conspicuous proliferation of SER in perivenular hepatocytes after PB administration, characteristic of adult liver, becomes manifest during postnatal development. In mouse hepatocytes, Vv (volume per unit cytoplasmic volume) of mitochondrial matrix and peroxisomes and Sv of mitochondrial inner membrane and cristae increase in both periportal and perivenular cells between birth and 10 days of age. Then, Vv of mitochondrial matrix remains unchanged in periportal cells but decreases in perivenular cells. In general, the process of postnatal hepatocyte differentiation appears to include several phases of development; cell organelles develop during the early postnatal period, subsequently the cells undergo both functional and structural heterogeneity, and the late postnatal period after weaning is the time for a marked increase in cell size.

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Section: Hepatocyteorganelles Rer and Golgi Complexmentioning

confidence: 97%

Fine structure and function of hepatocytes during development

Kanamura

Kanai

Watanabe

1990

J. Elec. Microsc. Tech.

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“…The experiments were conducted with small slices of liver rather than in the intact animal in order to permit more direct control of environmental conditions and to minimize cost of isotope . Liver slices can secrete specific proteins such as albumin (7,27,32,39,40,60), a-glycoprotein (56), high-and low-density lipoproteins (33,48), transferrin (34), fibrinogen (59), prothrombin, and Factor VII (46), and produce specific intracellular proteins such as ferritin (62), so that protein synthesis in slices appears to be qualitatively if not quantitatively normal .…”

Section: Introductionmentioning

confidence: 99%

Electron Microscopic Radioautographic Detection of Sites of Protein Synthesis and Migration in Liver

Ashley

Peters

1969

The Journal of Cell Biology

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The sites of synthesis of proteins and their subsequent migration in rat liver have been studied during a 75 min period after labeling of liver-slice proteins by exposure to leucine-H3 for 2 min. Incorporation of the label into protein began after 1 min and was maximal by 4 min. Electron microscopic radioautography showed that synthesis of proteins in hepatocytes occurs mainly on ribosomes, particularly those in rough endoplasmic reticulum and, to some extent, in nuclei and mitochondria. Most of the newly formed proteins leave the endoplasmic reticulum in the course of 40 min, and concurrently labeled proteins appear in Golgi bodies, smooth membranes, microbodies, and lysosomes. A likely pathway for the secretion of some or all plasma proteins is from typical rough endoplasmic reticulum to a zone of reticulum which is partially coated with ribosomes, to the Golgi apparatus, and thence to the cell periphery. The formation of protein by reticuloendothelial cells was measured and found to be about 5% of the total protein formed by the liver.

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“…The longest time without ingestion of protein-containing test diet or chow was 6.5 h. However, it should be noted that amino acid pools in the body are relatively small and protein reserves, strictly so called, are not generally established, and so it may be a matter of only some hours of protein deprivation before amino acid availability and net maintenance of body-protein content begin to fail (Halac, 1962;Wise & Oliver, 1967). The positively reinforcing effect of gastrically intubated balanced amino acid mixture has thus far been observed only in animals which have been food deprived at least overnight (Simson & Booth, 1974).…”

Section: Discussionmentioning

confidence: 99%

Acquired sensory preference for protein in diabetic and normal rats

Booth

1974

Psychobiology

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Plasma albumin synthesis during neonatal development of the rat

Cited by 20 publications

References 8 publications

Fine structure and function of hepatocytes during development

Fine structure and function of hepatocytes during development

Electron Microscopic Radioautographic Detection of Sites of Protein Synthesis and Migration in Liver

Acquired sensory preference for protein in diabetic and normal rats

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