Plasma aldosterone, cortisol and corticosterone concentrations in the new‐born guinea‐pig

Malinowska, Krystyna; Nathanielsz, P. W.

doi:10.1113/jphysiol.1974.sp010423

Cited by 38 publications

(17 citation statements)

References 19 publications

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“…It was shown that at the end of pregnancy the concentration of plasma aldosterone was increased (Beitins et al, 1972;Malinowska and Nathanielsz, 1974] which is in accord ance with our finding of a greater width of the zona glomerulosa at this stage. The trauma of parturition, loss of fluid, minimal hemorrhagia, as well as high levels of angiotensin I could be responsible for the enlargement of the zona glomerulosa noted in the early postpartum period [Beitinset al, 1972;Yates et al, 1974;Mott, 1975;Lammintausta et al, 1977].…”

Section: Discussionsupporting

confidence: 81%

Morphological aspect of the juxtaglomerular apparatus and adrenal zona glomerulosa during pregnancy in rabbits

Mrsevic¹,

Lačković²,

Mujović³

et al. 1980

Cells Tissues Organs

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The juxtaglomerular apparatus and zona glomerulosa were studied histologically in rabbits during the whole pregnancy period. The granularity of the kidney juxtaglomerular cells diminishes up to 25 days at which time it reaches control values. After delivery, the juxtaglomerular index increases significantly and rises above control values. The width of the adrenal zona glomerulosa is smaller in the first half of pregnancy in comparison with controls. In the second half it rises significantly. After delivery it greatly surpasses control values.

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Section: Discussionsupporting

confidence: 81%

Morphological aspect of the juxtaglomerular apparatus and adrenal zona glomerulosa during pregnancy in rabbits

Mrsevic¹,

Lačković²,

Mujović³

et al. 1980

Cells Tissues Organs

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“…Some other reports on cortisol levels in conscious, non-stressed guinea-pigs have given values lower thati those in this study. Blood cortisol concentrations in the present study were 19-3 /u,g/100 ml for males and 31-8 fig/100 ml for females compared with Malinowska and Nathanielsz's (1974) value for male plasma of 8-4 /Ag/100 ml and that of Fazekas, Homoki and Teller (1974) of 7-5 fig/lOO ml plasma for males and 12-6 /i,g/100 ml plasma for females. Speculative reasons for this discrepancy in cortisol values could include genetic differences in corticosteroid synthesis or metabolism, as has been demonstrated in guinea-pigs by Burstein, Kimbal and Bhavnani (1963) or strain differences in plasma corticosteroid-binding capacity as has been mentioned in the review by Shire (1974).…”

Section: Disgussionmentioning

confidence: 70%

“…three times that found for man. Malinowska and Nathanielsz (1974) found a mean plasma aldosterone concentration of 7-2 ng/100 ml in four conscious, non-stressed, adult, male guineapigs. In the present study (Table 2), sodium loading produced levels comparable with those in their report.…”

Section: Disgussionmentioning

confidence: 99%

Regulation of Aldosterone in the Guinea‐pig — Effect of Oestrus Cycle, Pregnancy and Sodium Status

Whipp

Wintour

et al. 1976

Aust J Exp Biol Med

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Summary. The blood concentrations of aldosterone, corticosterone and cortisol were measured in conscious, non-stressed guinea-pigs using a double isotope dilution derivative assay procedure. Aldosterone levels in the guinea-pig were high when compared with those of other species. The concentration of aldosterone, 37-9, ± 15-9 ng/100 ml {x ± SD), and cortisol, 31-8 ± 10-1 ng/100 ml, found in non-pregnant females on a moderate sodium intake was significantly greater than in males (aldosterone 22-2 ± 2-4 ng/100 ml and cortisol 19-3 ± 5-7 ng/100 ml). There was no sex difference in corticosterone concentration; females, 0-25 ± 0-06 ttg/100 ml and males, 0-23 ± 0-10 Mg/100 ml. The oestrus cycle had no effect on levels of the three steroids measured. Two thirds of the way through the 68-day gestation period aldosterone levels were significantly elevated compared with non-pregnant values (68-7 ± 50-9 ng/100 ml versus 37-9 ± 15-9 ng/100 ml, p < 0-05). Values at day 20 (33-2 ± 11-7 ng/100 ml) and day 60 of gestation (51-9 i 21-7 ng/100 ml) were similar to those of non-pregnant animals. Cortisol and corticosterone levels were significantly elevated at 20 days gestation and they continued to rise until, at day 60, cortisol was 9 times and corticosterone 4 times higher than the non-pregnant values. Compared with a moderate Na intake, salt loading suppressed aldosterone levels and Na restriction raised them.

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“…trypsin, pepsin and ovalbumin standards (Sig ma) were used. Concentrations of albumin in maternal scrum were determined by a brontocresol green dye binding method 110] and of corticosterone and insulin by a binding protein [9] and radioimmunoassay tech nique. respectively [3],…”

Section: Chemical Assaysmentioning

confidence: 99%

The Effect of Dietary Protein Concentration and Quality on the Hormonal Status, Protein Metabolism and Milk Protein Concentrations of Rats

Grimble

1981

Ann Nutr Metab

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Lactating rats were fed casein or cereal protein at one of two concentrations. Milk volume was severely reduced by poor dietary protein quality. Milk fat, lactose and free amino acid nitrogen were unaffected by the diets, whereas total milk protein was reduced by 20% on the cereal diets. Lactalbumin concentrations showed a greater decrease than that of other milk proteins. Changes in maternal serum insulin, corticosterone, albumin and body weight suggest maternal metabolism changes to provide substrate for milk synthesis. Total milk protein and serum albumin synthesis show similar sensitivity to dietary protein adequacy.

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Plasma aldosterone, cortisol and corticosterone concentrations in the new‐born guinea‐pig

Cited by 38 publications

References 19 publications

Morphological aspect of the juxtaglomerular apparatus and adrenal zona glomerulosa during pregnancy in rabbits

Morphological aspect of the juxtaglomerular apparatus and adrenal zona glomerulosa during pregnancy in rabbits

Regulation of Aldosterone in the Guinea‐pig — Effect of Oestrus Cycle, Pregnancy and Sodium Status

The Effect of Dietary Protein Concentration and Quality on the Hormonal Status, Protein Metabolism and Milk Protein Concentrations of Rats

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