Plasma ALP activity and blood PCV value changes in chick fetuses due to exposure of the egg to different xenobiotics

Kertész, Virág; Hlubik, I.

doi:10.1016/s0269-7491(01)00179-8

Cited by 12 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Signifi cant reduction in ALP level in this study is agreement with other researcher which mention that after injection with Benz (k) fl uoranthene the alteration in ALP enzyme activity and PCV values was apparent is indicative of the high sensitivity of chick fetuses 22 This result is consistent with studies dealing with the effect of chemical contamination , as the amount of this enzyme decreases compared to the control group .This increase can be adopted as evidence of chemical contamination after chronic exposure.…”

Section: Fig (1): Show the Level Of Liver Enzymes (Alt Ast And Alp) In The Serum Of Chick Embryos For Groups Asupporting

confidence: 92%

Study the Effect of Poly Aromatic Hydrocharbons by Using Biochemical Tests in Chicken Embryos

Sarab,S.Kadhum,

Sarab,R.Mustafa,

Suha, A.Ali

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

The major risk of polycyclic aromatic hydrocarbons (PAHs) in all ecosystems originates from human race activity such as petroleum refining and other industrial processes. PAHs cause several effects at low doses in animals in different ecosystem. The aim of this study was to assess the treatment of AL-Dura refinery wastes before being discharged to the river by studying their effects on the liver and renal functions in chicken embryos which used as a model exposed in vivo. One hundred and twenty local eggs were incubated horizontally at 37.5±0.5˚C with a relative humidity of 65% in an egg incubator. Sixty eggs were used for hatchability study, were as other sixty eggs were used for biochemical analysis. On day 15th of incubation, the eggs were randomly divided into three different treatment groups and marked for identification. The first A and second group B were exposed by injections with the residues of AL-Dura refinery (after treatment) and at the concentration of (2, 4) ppm respectively and 0.2 ml / egg into the air cell with sterile siring, then sealed with melted paraffin. Control group was injected with Olive oil. On day 18th of incubation the samples of blood were collected from embryos. Liver function was measured using a biochemical assay with diagnostic kits of specific enzymes (ALT, AST, and ALP). Ceratinine and urea level were measured to asses renal function. The result showed a signenificant increase p≥ .05in the level of liver enzymes (ALT, AST), ceratinine and urea by increasing the exposure dose, were as there is a decrease in the level of ALP with the increasing of exposure dose. Hatchability rat were significantly (p < 0.05) decreased with dose exposure increase. Mortalities in the chicken embryos of all groups showed dose-dependent relationship. That shows there are a clear effect of oil waste on liver and renal function, and an indication of the inefficient treatment of these waste before being discharged to the river.

show abstract

Section: Fig (1): Show the Level Of Liver Enzymes (Alt Ast And Alp) In The Serum Of Chick Embryos For Groups Asupporting

confidence: 92%

Study the Effect of Poly Aromatic Hydrocharbons by Using Biochemical Tests in Chicken Embryos

Sarab,S.Kadhum,

Sarab,R.Mustafa,

Suha, A.Ali

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

show abstract

“…Avian embryos exposed to fluoranthene and benz(k)fluoranthene, that is, two of the PAHs detected in our birds, showed liver necrosis and a decrease of alkaline phosphatase (ALP) activity (Kertesz and Hlubik, 2002). ALP is involved in phosphorus metabolism (Whittow, 2000).…”

Section: Discussionmentioning

confidence: 91%

Effects of acute exposure to heavy fuel oil from the Prestige spill on a seabird

2007

View full text Add to dashboard Cite

Large quantities of petroleum products are released into the marine environment as result of tanker wrecks. Such catastrophic events have a dramatic impact on marine ecosystems, affecting a broad range of species. Seabirds are placed at the uppermost trophic level of the marine food chain. Therefore, important toxic effects are expected in these organisms. The recent Prestige oil spill gave the opportunity to test this. A previous study reported that yellow-legged gulls (Larus michahellis) breeding in the oiled area (17 months after the spill) showed differences both in plasma biochemistry and in the total circulating levels of polycyclic aromatic hydrocarbons (TPAHs) in blood regard to gulls sampled in clean areas. In the present study, wild yellow-legged gulls were fed with heavy fuel oil from the Prestige oil spill (P-gulls) and compared with control gulls (C-gulls) fed only with the vehicle (vegetable oil). Consistent with the cited previous findings, gulls fed with fuel oil showed reduced glucose and inorganic phosphorus levels in plasma, as well as a trend to significantly reduced creatinine values. In addition, glucose concentration was negatively related to TPAH levels. Males but not females fed with fuel oil showed higher plasma activity of asparatate aminotransferase (AST) than controls. With regard to plasma activity of gamma-glutamyl transferase (GGT), the results were opposite to the previous study. The GGT activity increased in C-females, apparently to meet with increased liver metabolism due to egg laying demands, but not in P-females. Differences to the previous study possibly reflect different adaptive responses of these enzymes to an acute short-term exposure to heavy fuel oil. Since the yellow-legged gull belongs to a complex of species widely distributed throughout the Northern hemisphere, the results as a whole might provide a tool for future evaluations of short-and long-term effects of oil spills on seabirds. Decreased glucose and inorganic phosphorus levels in plasma are expected in both short-and long-lasting exposures to fuel oil, whereas responses of AST and GGT enzymes would depend on both the sex of individuals and the temporal pattern of exposure.

show abstract

“…The components can modify each other's toxic effect. Therefore, the examination of the combination of heavy metals and other chemicals gained signi cant ground in both avian (Fejes et al 2001;Kertész and Hlubik 2002) and mammalian (Institóris et al 2001;Pecze et al 2001) toxicological research studies. Furthermore, the interaction effects are examined not only in the eld of ecotoxicology, but also in all other areas dealing with health care and chemical safety issues (Oskarsson 1983;Danielsson et al 1984;Speijers and Speijers 2004).…”

Section: Introductionmentioning

confidence: 99%

Model study on chicken embryos to investigate potential teratogenic risk of wild birds due to pesticide and environmental contaminant

Lehel

Szemerédy

Szabó

et al. 2021

Preprint

View full text Add to dashboard Cite

Single and simultaneous toxic effects of glyphosate (Amega Up, 360 g/L, 4%) and copper sulphate (0.01%) were studied on avian embryos treated with injection directly into the air chamber or by immersion application for 30 minutes on day 0 of incubation. Alterations of the chicken embryos were evaluated during the necropsy performed on day 19 of incubation including the mortality, the body weight, and the type of developmental abnormalities. Based on the results, the injection application was to be more toxic than the immersion method, induced increasing of mortality and decreasing of body weight, and the incidence of the congenital anomalies was more frequent. Supposedly, an additive-type toxicodynamic interaction was occurred between the copper sulphate and glyphosate that may result in reduced vitality of the embryos and thus the number of offspring of wild-life birds.

show abstract

Plasma ALP activity and blood PCV value changes in chick fetuses due to exposure of the egg to different xenobiotics

Cited by 12 publications

References 9 publications

Study the Effect of Poly Aromatic Hydrocharbons by Using Biochemical Tests in Chicken Embryos

Study the Effect of Poly Aromatic Hydrocharbons by Using Biochemical Tests in Chicken Embryos

Effects of acute exposure to heavy fuel oil from the Prestige spill on a seabird

Model study on chicken embryos to investigate potential teratogenic risk of wild birds due to pesticide and environmental contaminant

Contact Info

Product

Resources

About