Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients

Jabir, Rafid Salim; Ho, Gwo Fuang; Annuar, Muhammad Azrif Bin Ahmad; Stanslas, Johnson

doi:10.1080/1354750x.2017.1334152

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…AGP-1 has been also identified as one of the potentially useful biomarkers for estimating the risk of all-cause mortality [36]. The glycosylated form of alpha-1-acid glycoprotein 1 is potential lung cancer and breast biomarker [37,38]. The level of alpha1-3 fucosylated glycoforms of AGP-1 is also increased in pancreatic cancer (PDAC) and could be potentially regarded as a PDAC biomarker [39].…”

Section: Alpha-1-acid Glycoprotein 1 (A1ag1_human)mentioning

confidence: 99%

Construction of 2DE-Patterns of Plasma Proteins: Aspect of Potential Tumor Markers

Naryzhny¹,

Ронжина²,

Zorina³

et al. 2022

Preprint

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Cancer is a complex systemic disease that changes the entire proteome. The analysis of this transformation makes it possible to determine tumor markers, that is, the most characteristic biomacromolecules produced by tumor cells. Here, the question of finding ideal tumor markers, which should be sensitive, specific, and reliable, is an acute issue. Unfortunately, none of the tumor markers, even those used in the clinic, has all these characteristics. Despite this, many tumor markers have demonstrated excellent clinical relevance for monitoring the effectiveness of different treatments for cancer patients. The use of markers also aids in the early detection of cancer recurrence and prognosis. Therefore, the situation in this area can be improved in two ways – by attempting to find an ideal single tumor marker or generating panels of different markers. In both cases, proteomics certainly plays a major role. Human plasma is one of the most popular samples as it is commonly collected in the clinic and provides noninvasive, rapid analysis for any type of disease including cancer. Many efforts have been applied in searching for “ideal” tumor markers digging very deep plasma proteome. There is a line of evidence that the most abundant, so-called “classical plasma proteins”, may be used to generate a tumor biomarker profile. To be comprehensive these profiles should have information not only about protein levels but proteoform distribution for each protein. Initially, the profile of these proteins in norm should be generated. Here, we present data about these profiles generated by two-dimensional electrophoresis with the following mass-spectrometry and immunodetection.

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Section: Alpha-1-acid Glycoprotein 1 (A1ag1_human)mentioning

confidence: 99%

Construction of 2DE-Patterns of Plasma Proteins: Aspect of Potential Tumor Markers

Naryzhny¹,

Ронжина²,

Zorina³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy

Yin,

Fu,

Wang

et al. 2024

Acta Biomaterialia

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Characterization of alpha-1-acid glycoprotein as a potential biomarker for breast cancer

Luo

Yin

2022

Bioengineered

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Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients

Abstract: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash.

Cited by 6 publications

References 21 publications

Construction of 2DE-Patterns of Plasma Proteins: Aspect of Potential Tumor Markers

Construction of 2DE-Patterns of Plasma Proteins: Aspect of Potential Tumor Markers

A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy

Characterization of alpha-1-acid glycoprotein as a potential biomarker for breast cancer

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