Plasma and Erythrocyte Lipid Peroxide Levels in Workers with Occupational Exposure to Lead

Dursun, Nurcan; Doǧan, Pakize; Dönmez, Hamiyet

doi:10.1385/bter:82:1-3:029

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…In agreement with a previous study, 18 Pb level was associated with duration of Pb exposure. Interestingly, duration of Pb exposure was also correlated with CAT, α‐tocopherol, β‐carotene and MDA in our study.…”

Section: Discussionsupporting

confidence: 93%

“…Significant association between MDA and indices of OS confirms the role of OS on the generation of LPO in erythrocytes of apprentices. The association between Pb and MDA supports Pb as the primary factor causing LPO and also, in agreement with recent studies, suggests this event as a possible mechanism for some of Pb’s toxic effects 17–22 …”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead

Ergürhan-İlhan

Cadir

Koyuncu-Arslan

et al. 2008

Pediatrics International

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead

Ergürhan-İlhan

Cadir

Koyuncu-Arslan

et al. 2008

Pediatrics International

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“…There was observed significantly higher plasma MDA levels (2.67 ± 0.69 μM) of workers exposed to lead than those in the control group (1.23 ± 0.61 μM) [51]. However, the results presented by Dursun et al indicate that increased concentrations of lipid peroxidation products in the blood of persons exposed to lead is dependent not only on the concentrations of lead, but also on the age and time of exposure [51].…”

Section: Discussionmentioning

confidence: 99%

“…However, the results presented by Dursun et al indicate that increased concentrations of lipid peroxidation products in the blood of persons exposed to lead is dependent not only on the concentrations of lead, but also on the age and time of exposure [51]. Other researches have also shown that MDA concentrations were elevated in the all heavy metal-treated groups compared to the control groups [52].…”

Section: Discussionmentioning

confidence: 99%

The Influence of the Occupational Exposure to Heavy Metals and Tobacco Smoke on the Selected Oxidative Stress Markers in Smelters

Ściskalska

Zalewska

Grzelak

et al. 2014

Biol Trace Elem Res

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The aim of the study was to verify if there is any association between exposure to Cu, Zn, Cd, Pb, As and the formation of malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), advanced oxidation protein products (AOPP), and whether in this process cigarette smoking plays a role. The investigations were performed in the 352 smelters occupationally exposed to heavy metals and 73 persons of control group. Metals concentration was determined by atomic absorption spectrometry. MDA and AOPP concentrations were determined by spectrophotometric methods. The concentration of 8-OHdG was determined by ELISA method. It was demonstrated an increased Cu concentration in smoking smelters compared to non-smoking control group. It was noted no differences in Zn and Mg concentrations between the examined groups. Pb concentration was more than sixfold higher in the group of smoking smelters and about fivefold higher in the group of non-smoking smelters compared to the control groups (smokers and non-smokers). It was shown that Cd concentration in the blood was nearly fivefold higher in the smoking control group compared to the non-smoking control group and more than threefold higher in the group of smoking smelters compared to non-smoking. It was shown an increased As concentration (more than fourfold) and decreased Ca concentration in both groups of smelters compared to control groups. In groups of smelters (smokers and non-smokers), twofold higher MDA and AOPP concentrations, and AOPP/albumin index compared to control groups (smokers and non-smokers) were shown. Tobacco smoke is the major source of Cd in the blood of smelters. Occupational exposure causes accumulation of Pb in the blood. Occupational exposure to heavy metals causes raise of MDA concentration and causes greater increase in AOPP concentration than tobacco smoke.

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“…Lead induces oxidative stress to the brain, heart, kidney and reproductive organs by affecting membranes, DNA and antioxidant defence systems of cells ( 1 ) . Aside from lipid peroxidation reactions evidenced by elevations in malondialdehyde, lead appears to enhance oxidative damage to DNA as shown by an increase of 8-hydroxydeoxyguanosine (8-OHdG) ( 2 – 4 ) . In epidemiological studies, blood lead levels (BLL) have been reported to have adverse health impacts such as oxidative stress, mortality and raised homocysteine levels ( 5 – 7 ) .…”

mentioning

confidence: 99%

Blood lead level modifies the association between dietary antioxidants and oxidative stress in an urban adult population

Hong

Kwon

et al. 2012

Br J Nutr

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Oxidative stress may be affected by lead exposure as well as antioxidants, yet little is known about the interaction between dietary antioxidants and blood lead levels (BLL) on oxidative stress level. We investigated the interaction between dietary antioxidants and BLL on oxidative stress level. As part of the Biomarker Monitoring for Environmental Health conducted in Seoul and Incheon, Korea, between April and December 2005, we analysed data from 683 adults (female ¼ 47·4 %, mean age 51·4 (SD 8·4) years) who had complete measures on BLL, dietary intakes and oxidative stress marker (urinary 8-hydroxy-2 0 -deoxyguanosine (8-OHdG)). Dietary intakes were assessed by a validated semi-quantitative FFQ, BLL was measured using atomic absorption spectrophotometry, and 8-OHdG by ELISA. Multivariate linear regression analyses were used to evaluate the influence of BLL on the association between dietary antioxidants and 8-OHdG. Geometric means of BLL and 8-OHdG concentrations were 4·1 (SD 1·5) mg/dl and 5·4 (SD 1·9) mg/g creatinine, respectively. Increases of vitamins C and E were significantly associated with the decrease of log10 8-OHdG in the adults from the lowest quartile of the BLL group (# 3·18 mg/dl, geometric mean ¼ 2·36 mg/dl) than those of the highest quartile BLL group (. 5·36 mg/dl, geometric mean ¼ 6·78 mg/dl). Regarding antioxidant-related foods, vegetables excluding kimchi showed a higher inverse relationship with 8-OHdG in the lowest quartile BLL group than the highest group. These findings suggest a rationale for lowering the BLL and increasing the intake of dietary antioxidants in the urban population in Korea.Key words: Diet: Antioxidants: Blood lead levels: Oxidative stress: Urban populations Chronic exposure to environmental chemicals, adversely affecting the health of large numbers of people, is a global problem. Among the chemicals, lead continues to pose adverse health effects because it is related to a broad range of physiological, biochemical and behavioural dysfunctions (1) .Lead induces oxidative stress to the brain, heart, kidney and reproductive organs by affecting membranes, DNA and antioxidant defence systems of cells (1) . Aside from lipid peroxidation reactions evidenced by elevations in malondialdehyde, lead appears to enhance oxidative damage to DNA as shown by an increase of 8-hydroxydeoxyguanosine (8-OHdG) (2 -4) . In epidemiological studies, blood lead levels (BLL) have been reported to have adverse health impacts such as oxidative stress, mortality and raised homocysteine levels (5 -7) .Oxidative stress is implicated in the aetiology of many diseases and considered as an important pathophysiological process (8,9) . Antioxidant nutrients are thought to modulate oxidative damage by influencing a balance between free radical production and antioxidant capacity (8) . A number of studies have shown that antioxidant nutrients such as vitamin C, vitamin E and/or b-carotene may decrease the biomarkers of oxidative stress, although some studies indicate a harmful effect of high-d...

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Plasma and Erythrocyte Lipid Peroxide Levels in Workers with Occupational Exposure to Lead

Cited by 9 publications

References 16 publications

Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead

Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead

The Influence of the Occupational Exposure to Heavy Metals and Tobacco Smoke on the Selected Oxidative Stress Markers in Smelters

Blood lead level modifies the association between dietary antioxidants and oxidative stress in an urban adult population

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