Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs

Bidgood, T. L.; Papich, Mark G.

doi:10.1111/j.1365-2885.2005.00664.x

Cited by 68 publications

(84 citation statements)

References 57 publications

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“…Therefore, it is necessary to determine the active concentration of free antimicrobial drugs at the target site using PK-PD modeling to achieve a rational dosage regimen. Previous studies have reported the application of an ultrafiltration sampling technique for isolating the free (unbound) drug in the gastrointestinal tract of calves, and in the ISF of different tissues (e.g., intramuscular, subcutaneous, and intrapleural tissues) of calves, sheep, and pigs 27, 28, 30, 31 .…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine

Lei

Xie

Chen

et al. 2017

Sci Rep

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The purpose of this study was to evaluate the activity of cyadox against Clostridium perfringens in swine and optimize the dosage regimen using ex vivo pharmacokinetic-pharmacodynamic (PK-PD) modeling. After oral administration, the ileum fluid of pigs containing the free cyadox was collected by implanted ultrafiltration probes. The Tmax, AUC24h, and CL/F of free cyadox in the ileum fluid were 1.96 h, 106.40 μg/h/mL, and 0.27 L/kg/h, respectively. Cyadox displayed a concentration-dependent killing action against C. perfrignens. The minimum inhibitory concentration (MIC) of cyadox against 60 clinical isolates ranged from 0.5 to 8 μg/mL, with MIC50 and MIC90 values of 2 and 4 μg/mL, respectively. The MIC was 2 μg/mL against the pathogenic C. perfrignens isolate CPFK122995 in both broth and ileum fluid. According to the inhibitory sigmoid Emax modeling, the AUC24h/MIC ratios of ileum fluid required to achieve the bacteriostatic, bactericidal, and virtual bacterial elimination effects were 26.72, 39.54, and 50.69 h, respectively. Monte Carlo simulations for the 90% target attainment rate (TAR) predicted daily doses of 29.30, 42.56, and 54.50 mg/kg over 24 h to achieve bacteriostatic, bactericidal, and elimination actions, respectively. The results of this study suggest that cyadox is a promising antibacterial agent for the treatment of C. perfringens infections, and can be used to inform its clinical use.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine

Lei

Xie

Chen

et al. 2017

Sci Rep

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“…Previous studies have shown that FQs could be converted into their epimers in different environments. For example, transformation from EFX to CFX was reported in plant root systems (Liu et al 2013); the biotransformation of CFX and NFX by microorganisms was confirmed (Parshikov et al 2001;Sukul and Spiteller 2007), and the same transformation was even reported in animals (Bidgood and Papich 2005;Fu et al 2008). The transformation to CFX altered the original distributions of EFX and NFX in manure and soil matrix.…”

Section: Discussion Fqs Pollution and Contributory Factorsmentioning

confidence: 83%

Using robust Bayesian network to estimate the residuals of fluoroquinolone antibiotic in soil

Xie

et al. 2015

Environ Sci Pollut Res

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Prediction of antibiotic pollution and its consequences is difficult, due to the uncertainties and complexities associated with multiple related factors. This article employed domain knowledge and spatial data to construct a Bayesian network (BN) model to assess fluoroquinolone antibiotic (FQs) pollution in the soil of an intensive vegetable cultivation area. The results show: (1) The relationships between FQs pollution and contributory factors: Three factors (cultivation methods, crop rotations, and chicken manure types) were consistently identified as predictors in the topological structures of three FQs, indicating their importance in FQs pollution; deduced with domain knowledge, the cultivation methods are determined by the crop rotations, which require different nutrients (derived from the manure) according to different plant biomass. (2) The performance of BN model: The integrative robust Bayesian network model achieved the highest detection probability (pd) of high-risk and receiver operating characteristic (ROC) area, since it incorporates domain knowledge and model uncertainty. Our encouraging findings have implications for the use of BN as a robust approach to assessment of FQs pollution and for informing decisions on appropriate remedial measures.

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“…3 In dogs, approximately 80% of marbofloxacin circulates unbound in the plasma. 34 The drug is only minimally (10% to 15% of the drug dose) metabolized by the liver into 2 main metabolites, N-desmethyl-marbofloxacin and N-oxide marbofloxacin. 35 Forty percent of an orally administered dose of marbofloxacin in dogs is excreted unchanged in the urine, with the remainder excreted unchanged via the bile in the feces.…”

Section: Discussionmentioning

confidence: 99%

Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits

Carpenter

Pollock²,

Koch³

et al. 2009

ajvr

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OBJECTIVE-To determine the pharmacokinetics of marbofloxacin after oral administration every 24 hours to rabbits during a 10-day period. ANIMALS-8 healthy 9-month-old female New Zealand White rabbits. PROCEDURES-Marbofloxacin (5 mg/kg) was administered orally every 24 hours to 8 rabbits for 10 days. The first day of administration was designated as day 1. Blood samples were obtained at 0, 0.17, 0.33, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 8, 12, and 24 hours on days 1 and 10 of marbofloxacin administration. Plasma marbofloxacin concentrations were quantitated by use of a validated liquid chromatography-mass spectrometry assay. Pharmacokinetic analysis of marbofloxacin was analyzed via noncompartmental methods. RESULTS-After oral administration, mean +/- SD area under the curve was 10.50 +/- 2.00 microg.h/mL and 10.90 +/- 2.45 microg.h/mL, maximum plasma concentration was 1.73 +/- 0.35 microg/mL and 2.56 +/- 0.71 microg/mL, and harmonic mean terminal half-life was 8.0 hours and 3.9 hours for days 0 and 10, respectively. CONCLUSIONS AND CLINICAL RELEVANCE-Marbofloxacin administered orally every 24 hours for 10 days appeared to be absorbed well and tolerated by rabbits. Administration of marbofloxacin at a dosage of 5 mg/kg, PO, every 24 hours is recommended for rabbits to control infections attributable to susceptible bacteria.

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Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs

Cited by 68 publications

References 57 publications

Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine

Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine

Using robust Bayesian network to estimate the residuals of fluoroquinolone antibiotic in soil

Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits

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