Plasma-Assisted Preparation of High-Performance Chitosan Nanofibers/Gauze Composite Bandages

Abstract

In this work, novel composite bandages were prepared by electrospinning chitosan nanofibers on 100% cotton substrate fabric. In the composite bandages, chitosan nanofiber web serves as a primary wound dressing whereas cotton substrate as a backing material. Cotton substrate was given plasma pretreatment and composite bandages were given plasma posttreatment to improve the durability of composite bandages and adhesion between nanofiber and cotton substrate layers. The adhesion of the nanofibers to the substrates was assessed by qualitative and quantitative techniques. Plasma pretreatment of the substrate with 100% helium and 99% helium=1% oxygen plasmas showed up to four times increase in force required to peel off the nanofiber layer. Even more increase in adhesion was obtained when composite bandages were given plasma pretreatment to substrate as well as posttreatment to composite bandages. Storage modulus, glass transition temperature, and crystallinity of untreated He and He=O 2 -plasma treated chitosan nanofiber web were studied to observe the effect of plasma treatment on the chitosan nanofibers using dynamic mechanical analysis, differential scanning calorimetry, and wide angle X-ray diffraction, respectively. To understand the mechanism of improved adhesion, surface elemental analysis of plasma treated chitosan nanofibers and cotton substrate was carried out using X-ray photoelectron spectroscopy.

Progress in Hydrogels for Skin Wound Repair

“…Hydrogel dressings, as a new kind of materials developed in recent years are expected to replace traditional wound dressing. When traditional dressings like gauze [101] or bandages [102] are used in treating skin traumas caused by abrasions, skin inflammation, ulcers and other skin injuries, there still exist many limitations and drawbacks like bringing sever pain to the patients and being unadaptable to irregular defects. Moreover, secondary injury would be caused by replacing of dressing and unmatched biodegradability would greatly delayed wound closure.…”

Chitin/Chitosan: Versatile Ecological, Industrial, and Biomedical Applications

“…For example, a blend of chitosan (short fibers) with cotton (long fibers) yarn by spinning technology is desirable for medical applications (Lam et al 2017). Gauze bandages for wound dressing were prepared by electrospinning of chitosan nanofibers and cotton fabric (Nawalakhe et al 2015). Plasma treatment was applied to improve adhesion by increased cross-linking between the two fiber systems imparting subsequent durability (Nawalakhe et al 2015).…”

“…Gauze bandages for wound dressing were prepared by electrospinning of chitosan nanofibers and cotton fabric (Nawalakhe et al 2015). Plasma treatment was applied to improve adhesion by increased cross-linking between the two fiber systems imparting subsequent durability (Nawalakhe et al 2015). Pure chitosan microfibers produced by wet spinning process was aimed for possible stable 3-D scaffold woven or nonwoven textile fabrics to be used in regenerative medicine such as bone and cartilage engineering (Toskas et al 2013).…”

Modification of electrospun PVA/PAA scaffolds by cold atmospheric plasma: alignment, antibacterial activity, and biocompatibility

“…This cost-effective and environmentally friendly technique also noticeably alters surface properties, including the material's hydrophilicity and biocompatibility [4,5]. Numerous synthetic and natural polymers have been used in CAP technology, including chitosan [6][7][8][9][10], polycaprolactone [11][12][13], poly(lactic acid) [14], poly(lactic acid-co-glycolic acid) [15], poly(vinyl alcohol) [4,16], and polyurethane [17] in the form of gels [18,19], nanoparticles [11,20], and electrospun nanofibers [21,22]. Of these, the electrospun fibrous scaffolds can be especially interesting due to their flexibility, high surface-to-volume ratio, porosity, and structural characteristics [23,24].…”