Plasma Asymmetric Dimethylarginine (ADMA) Is Associated With Retinopathy in Type 2 Diabetes

Małecki, Maciej; Undas, Anetta; Cyganek, Katarzyna; Mirkiewicz-Sieradzka, B; Wołkow, Paweł; Osmenda, Grzegorz; Waluś-Miarka, Małgorzata; Guzik, Tomasz J.; Sieradzki, Jacek

doi:10.2337/dc07-1138

Cited by 58 publications

(51 citation statements)

References 15 publications

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“…Therefore, it may be concluded that SDMA increases more than ADMA and is a better indicator of renal clearance. This result is compatible with the relation detected between renal clearance and ADMA and SDMA levels in the literature (3,12,20,24).…”

Section: Discussionsupporting

confidence: 81%

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Effect of Exercise on ADMA Level in Type 2 Diabetes Mellitus

Taskiran¹,

Altun²,

Vardar³

et al. 2012

Balkan Med J

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Objective: The increase in symmetric (SDMA) and asymmetric dimethyl arginine (ADMA) is associated with endothelial dysfunction. The aim of this study was to evaluate the effect of exercise on ADMA and SDMA levels and related ratios in type 2 DM.Material and Methods: Thirty-six women with type 2 DM and 44 healthy women were recruited to the study. Fourteen and 19 subjects, respectively, attended four-weeks of moderate intensity exercise. Plasma SDMA, ADMA, and L-arginine levels were measured by the HPLC method initially, after the first exercise session, and after one month.Results: All measurements were within the normal range in both groups and did not change significantly immediately after exercise and after the first month. In the healthy group, L-arginine/ADMA and L-arginine/SDMA ratios after one month were significantly higher than the initial values (p<0.022 and p=0.017, respectively). After one month of exercise, L-arginine/ADMA and L-arginine/SDMA ratios increased in diabetics and decreased in healthy subjects when compared to those after the first exercise session (p=0.026 and p=0.037, respectively). Conclusion:We suggest that L-arginine/ADMA and L-arginine/SDMA ratios should be used in spite of absolute values. These molecules have a substantial role in the beneficial effects of exercise in healthy subjects while their role is small in diabetics.

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Section: Discussionsupporting

confidence: 81%

“…Furthermore, ADMA increases 2-3 fold in type 2 DM (4,(10)(11)(12). L-arginine levels hover in the normal range in these clinical situations where ADMA increases.…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise on ADMA Level in Type 2 Diabetes Mellitus

Taskiran¹,

Altun²,

Vardar³

et al. 2012

Balkan Med J

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“…But in another study, Sibal et al found, similar to our findings, that there was a reduction in ADMA levels in adults with type 1 DM compared to controls (22). It has been reported in some studies that ADMA levels are both higher in diabetic patients with retinopathy than in those without retinopathy, and higher in diabetic patients with or without diabetic retinopathy than in controls (23). In another study, it was demonstrated that patients with severe diabetic retinopathy had higher ADMA levels in plasma and aqueous humor than did those without diabetes (24).…”

Section: Discussionsupporting

confidence: 77%

Diyabetik nöropatili hastalarında serum asimetrik dimetilarjinin ve nitrik oksit düzeyleri

...

2012

npa

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Re cei ved/Ge liş ta ri hi: 21.07.2011 Ac cep ted/Ka bul ta ri hi: 16.12.2011 © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing / © Nö rop si ki yat ri Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. ABS TRACTObjective: Asymmetric dimethylarginine (ADMA) is a novel marker of endothelial dysfunction. ADMA is an endothelial nitric oxide synthase inhibitor. Due to scarcity of studies on the role of ADMA in pathogenesis of diabetic neuropathy, it remains to be determined whether blood ADMA and nitric oxide (NO) levels are associated with diabetic neuropathy. In this case control study, we aimed to evaluate the relationship between serum NO and ADMA levels among diabetic neuropathy cases Methods: 48 patients with diabetic neuropathy and 34 healthy subjects were included in the study. All type 2 diabetic patients underwent electrophysiological and neurological examination. NO levels were determined using the Griess method. Serum ADMA levels were determined by using the ELISA method. Results: The serum ADMA levels in diabetic neuropathy patients were found to be statistically significantly lower than those of the control group (p=0.005). However, a statistically significant increase was observed in serum NO levels in patients with diabetic neuropathy compared with those in the control group (p = 0.009). A negative correlation was found between NO levels and ADMA levels (p=0.041, r=-0.23). Discussion: Changes in NO and ADMA levels in the blood of diabetic neuropathy patients may indicate oxidative stress and endothelial dysfunction in the pathogenesis of diabetic neuropathy. (Arc hi ves of Neu ropsy chi atry 2012; 49: 183-187)

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“…Plasma ADMA concentrations have been shown to be elevated in individuals with increased cardiovascular disease risk [8][9][10][11], older individuals [12], and in patients with type 2 diabetes [4,5,13]. Elevated plasma ADMA concentrations are thought to play a role in endothelial dysfunction and associated vascular complications seen in individuals with type 2 diabetes [14][15][16].While regular physical exercise has been shown to improve endothelial function in individuals with type 2 diabetes [17,18], the pathophysiological basis for these exerciseinduced improvements remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Serre

Simmonds²,

Sabapathy³

et al. 2012

Endocrinol Metabol Syndrome

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Aims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods:Fourteen women (aged 69 ± 3 yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training.Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation:Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.

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Plasma Asymmetric Dimethylarginine (ADMA) Is Associated With Retinopathy in Type 2 Diabetes

Cited by 58 publications

References 15 publications

Effect of Exercise on ADMA Level in Type 2 Diabetes Mellitus

Effect of Exercise on ADMA Level in Type 2 Diabetes Mellitus

Diyabetik nöropatili hastalarında serum asimetrik dimetilarjinin ve nitrik oksit düzeyleri

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

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