Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: A comparative study

Schmieder, Patricia K.; Henry, Tala R.

doi:10.1016/0742-8413(88)90052-7

Cited by 18 publications

(14 citation statements)

References 14 publications

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“…Vertical bars and points represent the mean -+ SD. The linear line of PCP residue on a logarithmic scale against depuration time was fitted by using LINEAR, a linear least-squares computer program (Wakabayashi 1984) by seawater acclimation (Huchinson and Hawkins 1990;PlazaYglesias et al 1988;Assem and Hanke 1979) may also affect the bile excretion of PCP bound to the plasma protein in a high degree (Schmieder and Henry 1988).…”

Section: Discussionmentioning

confidence: 99%

The effects of salinity on pentachlorophenol accumulation and elimination by killifish (Oryzias latipes)

Tachikawa

Sawamura

1994

Arch. Environ. Contam. Toxicol.

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Abstract. Fresh water and seawater acclimated (FWA and SWA) killifish (Oryzias latipes) were exposed to pentachlorophenol (PCP) at various salinities (1.2-18.7'/oo). The PCP accumulation in the fish decreased with increase of salinity. As the salinity increased [Woo (freshwater) -18.67o0], the PCP clearance rate increased from 0.0097 to 0.0170 (h-l). A substantial increase of the clearance rate was observed when the salinity was over 9.3?o0. The PCP uptake rate decreased from 20.8 to 10.6 (m1-1 g-1 fish h -1) with the increase of salinity. The uptake rate decreased at a lower salinity (~<4.7%o). The excretion of PCP glucuronide (PCP-G) increased markedly at the salinity of 9.3%o, although that of PCP sulfate (PCP-S) did not change. The increase of PCP-G excretion may correspond to the increase of clearance rate. Abrupt transfer of FWA and SWA killifish to a PCP solution with a different salinity decreased the PCP accumulation and increased the PCP metabolite excretion with the increase of the salinity. However, the amount of PCP accumulated by FWA was greater than that by SWA killifish.Aquatic habitats are divided into fresh, brackish and seawater environment. Many chemical pollutants are widely detected in these areas. Differences between seawater and freshwater accli= mated (SWA and FWA) fishes in accumulation and elimination of chemical pollutants have been reported (Canton et al. 1975(Canton et al. , 1978Tsuda et al. 1990;Tachikawa et al. 1987aTachikawa et al. , 1987bTachikawa et al. , 1991. These findings indicated that salinity can affect the accumulation and elimination of environmental pollutants in fish. Some studies have indicated that osmotic regulation in euryhaline fish is dependent on the salinity of the environment (Assem and Hanke 1979;Vislie and Fugelli 1984; PlazaYglesias et al. 1988;Hutchinson and Hawkins 1990). Examination of the uptake and clearance of chemicals associated with salinity changes in the environment may elucidate the effects of osmotic regulation in the accumulation and elimination of chemicals.Correspondence to: M. Tachikawa Previously, we reported the differences between FWA and SWA killifish Oryzias latipes in the accumulation and elimination of pentachlorophenol (PCP) (Tachikawa et al. 1991). Acclimation to seawater lowered the estimated bioconcentration factor (BCF) of PCP for killifish from 1680 to 370. The smaller uptake rate and the faster clearance rate resulted in the lower BCF of PCP for killifish in seawater. The greater excretion of PCP glucuronide by seawater killifish may be responsible for the rapid elimination of PCP.Herein, PCP accumulation, PCP uptake and clearance rates and PCP conjugates excretion by killifish acclimated to different salinities (1.2-18.7%o) were determined. Materials and Methods WaterFreshwater was reconstituted fresh water containing 26.1 mg CaC12 • 2H20, 18.2 mg MgSO 4 • 7H20, 1.1 nag K2SO4, and 25.3 mg NaHCO 3 in 1 L of deionized water. Seawater (salinity: 35%0) was reconstituted seawater by Lyman and Fleming (1940). The pH of the fresh w...

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Section: Discussionmentioning

confidence: 99%

The effects of salinity on pentachlorophenol accumulation and elimination by killifish (Oryzias latipes)

Tachikawa

Sawamura

1994

Arch. Environ. Contam. Toxicol.

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“…For example, the proportions of phenol bound to dog and rat plasma were estimated to be about 50% and 60%, respectively (Liao and Oehme 1981). The more acidic pentachlorophenol shows even a higher degree of binding (>99%) to rat plasma proteins (Schmieder and Henry 1988). Ipriflavone (7-isopropoxy-3-phenyl-chromen-4-one), an isoflavone derivative without free phenolic groups, displayed about 96% binding to 4% human serum albumin (Kim et al 1999).…”

Section: Unspecific Protein Bindingmentioning

confidence: 99%

Distribution and unspecific protein binding of the xenoestrogens bisphenol A and daidzein

Csanády

Oberste-Frielinghaus

Semder

et al. 2002

Archives of Toxicology

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Physiological toxicokinetic (PT) models are used to simulate tissue burdens by chemicals in animals and humans. A prerequisite for a PT model is the knowledge of the chemical's distribution among tissues. This depends on the blood flow and also on the free fraction of the substance and its tissue:blood partition coefficients. In the present study we determined partition coefficients in human tissues at 37 degrees C for the two selected xenoestrogens bisphenol A (BA) and daidzein (DA), and their unspecific binding to human serum proteins. Partition coefficients were obtained by incubating blood containing BA or DA with each of the following tissues: brain, liver, kidney, muscle, fat, placenta, mammary gland, and adrenal gland. Blood samples were analysed by HPLC. For BA and DA, all partition coefficients in non-adipose tissues were similar (average values: BA 1.4, DA 1.2). However, the lipophilic properties of both compounds diverge distinctly. Fat:blood partition coefficients were 3.3 (BA) and 0.3 (DA). These values indicate that with the exception of fat both compounds are distributed almost equally among tissues. In dialysis experiments, the unspecific binding of BA and DA with human serum proteins was measured by HPLC. For BA, the total concentration of binding sites and the apparent dissociation constant were calculated as 2000 and 100 nmol/ml, respectively. Because of the limited solubility of DA, only the ratio of the bound to the free DA concentration could be determined and was found to be 7.2. These values indicate that at low concentrations only small percentages of about 5% (BA) and 12% (DA) are as unbound free fractions in plasma. Since only the unbound fraction can bind to the estrogen receptor, binding to serum proteins represents a mechanism that limits the biological response in target tissues.

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“…5A and B). Once an organic compound diffuses across the gills it will likely become bound to a protein carrier present in the blood (Schmieder and Henry, 1988). Sex hormone binding globulin (SHBG) has been implicated as the possible transport protein required for EE2 movement in fish (Miguel-Queralt and Hammond, 2008).…”

Section: The Mechanism Of Ee2 Uptakementioning

confidence: 99%

The effects of temperature and salinity on 17-α-ethynylestradiol uptake and its relationship to oxygen consumption in the model euryhaline teleost (Fundulus heteroclitus)

2013

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Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: A comparative study

Cited by 18 publications

References 14 publications

The effects of salinity on pentachlorophenol accumulation and elimination by killifish (Oryzias latipes)

The effects of salinity on pentachlorophenol accumulation and elimination by killifish (Oryzias latipes)

Distribution and unspecific protein binding of the xenoestrogens bisphenol A and daidzein

The effects of temperature and salinity on 17-α-ethynylestradiol uptake and its relationship to oxygen consumption in the model euryhaline teleost (Fundulus heteroclitus)

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