Plasma calcitonin and parathyroid hormone levels in growing pigs on different diets. I. — High phosphorus diet

Pointillart, Alain; Garel, Jean‐Michel; Guéguen, L.; Colin, Colette

doi:10.1051/rnd:19780407

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Zayed et al, have shown that calcitonin levels increase after ingestion of food (without specifying the type of food) [ 66 ]. A study in pigs showed that a diet high in phosphorus increased calcitonin levels [ 67 ], while a study in rats showed that a diet high in fat increased calcitonin levels [ 68 ].…”

Section: Environmental Factors That Affect Pth and Calcitonin Levelsmentioning

confidence: 99%

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Leko

Pleić

Gunjača

et al. 2021

IJMS

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Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.

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Section: Environmental Factors That Affect Pth and Calcitonin Levelsmentioning

confidence: 99%

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Leko

Pleić

Gunjača

et al. 2021

IJMS

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Tolerance to 1,25 dihydroxyvitamin D3 glycosides from Solanum glaucophyllum by the growing pig

Schlegel

Guggisberg

Gutzwiller

2017

Research in Veterinary Science

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Solanum glaucophyllum leaves contain high levels of glycosidically bound 1,25 dihydroxyvitamin D, the most important vitamin D metabolite. The tolerance to this source was evaluated during six weeks with fifty weaned pigs fed increasing levels (0, 2.5, 5, 10 and 20μg 1,25(OH)D/kg diet). The diet contained, per kg, 9.7g Ca, 3.5g digestible P and 2000IU cholecalciferol. Ten additional pigs were fed a diet containing 1000IU cholecalciferol/kg, without 1,25(OH)D. Weekly plasma and final kidney, bone and urinary mineral contents, bone density and breaking strength served as indicators for possible adverse effects of the supplement. All animals grew well and remained clinically healthy. The measured parameters remained unchanged when 1000 replaced 2000IU cholecalciferol/kg and when 1,25(OH)D was fed up to 10μg/kg. Twenty μg 1,25(OH)D increased plasma Ca and decreased plasma P from the 2 and the 4 experimental week onwards, respectively. Twenty μg 1,25(OH)D increased final plasma Ca and 1,25(OH)D and reduced final plasma P by respectively 19, 56 and 13%. Twenty μg 1,25(OH)D also increased kidney Ca and urinary Ca by 43 and 69%, respectively, reduced bone breaking strength by 12% and tended to decrease bone ash by 3%. To conclude, 2000IU D was not beneficial compared to 1000IU cholecalciferol; up to 10μg 1,25(OH)D per kg diet did not lead to observed adverse effects; 20μg 1,25(OH)D altered the homeostatic regulation of Ca and P thus, may lead to first signs of possible adverse effects, such as soft tissue calcification.

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Plasma calcitonin and parathyroid hormone levels in growing pigs on different diets. I. — High phosphorus diet

Abstract: Summary. Ten Introduction.

Cited by 2 publications

References 22 publications

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Tolerance to 1,25 dihydroxyvitamin D3 glycosides from Solanum glaucophyllum by the growing pig

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